ANKH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANKH_HUMAN
• UniProt AC: Q9HCJ1
• Protein Name: Progressive ankylosis protein homolog
• Gene Name: ANKH
• Organism: Homo sapiens (Human).
• Sequence Length: 492
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter..
• Protein Sequence: MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLVSTSNTVTAAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVVPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLIASLVVLPYLGVHGATLGVGSLLAGFVGESTMVAIAACYVYRKQKKKMENESATEGEDSAMTDMPPTEEVTDIVEMREENE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	HYWPLIRFLVPLGIT CHHHHHHHHHHHCCC	6.81	-
42	Ubiquitination	NRGIAAVKEDAVEML HHCCCCHHHHHHHHH	45.19	21963094
52	Ubiquitination	AVEMLASYGLAYSLM HHHHHHHHHHHHHHH	15.56	21963094
57	Ubiquitination	ASYGLAYSLMKFFTG HHHHHHHHHHHHHHC	19.17	22817900
67	Phosphorylation	KFFTGPMSDFKNVGL HHHHCCHHHCCCEEE	42.92	24719451
70	Ubiquitination	TGPMSDFKNVGLVFV HCCHHHCCCEEEEEE	56.57	21963094
79	Phosphorylation	VGLVFVNSKRDRTKA EEEEEECCCCCCHHH	24.62	24719451
80	Ubiquitination	GLVFVNSKRDRTKAV EEEEECCCCCCHHHH	53.79	21963094
85	Ubiquitination	NSKRDRTKAVLCMVV CCCCCCHHHHHHHHH	37.07	22817900
99	Ubiquitination	VAGAIAAVFHTLIAY HHHHHHHHHHHHHHH	2.39	21963094
107	Ubiquitination	FHTLIAYSDLGYYII HHHHHHHHHHHHHHH	19.82	-
127	Ubiquitination	VDESVGSKTRRAFLY CCCCCCHHHHHHHHH	39.87	21906983
186	Ubiquitination	LLHSHLECREPLLIP HHHHHCCCCCCCHHH	8.21	21963094
214	Ubiquitination	TLCLGYYKNIHDIIP HHHHHHHCCHHHHCC	40.73	21963094
300	Phosphorylation	LTEIRAVYPAFDKNN HHHHHHHHCCCCCCC	6.45	22817900
305	Ubiquitination	AVYPAFDKNNPSNKL HHHCCCCCCCCCCCC	52.77	-
315	Phosphorylation	PSNKLVSTSNTVTAA CCCCCEECCCCCCHH	20.65	23403867
470	Phosphorylation	SATEGEDSAMTDMPP CCCCCCCCCCCCCCC	18.68	50565229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANKH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANKH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANKH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RSSA_HUMAN	RPSA	physical	21988832

Drug and Disease Associations

• Kegg Disease
• H00491: Craniometaphyseal dysplasia
• H01236: Familial articular chondrocalcinosis
• OMIM Disease
• 118600: Chondrocalcinosis 2 (CCAL2)
• 123000: Craniometaphyseal dysplasia, autosomal dominant (CMDD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.