ANK3_RAT - dbPTM
ANK3_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ANK3_RAT
UniProt AC O70511
Protein Name Ankyrin-3
Gene Name Ank3
Organism Rattus norvegicus (Rat).
Sequence Length 2622
Subcellular Localization Cytoplasm, cytoskeleton. Cell projection, axon. Cell membrane. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. Lysosome. In root dorsal ganglia, predominantly located in the axolemma of the axon proximal segments. Also
Protein Description Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity)..
Protein Sequence MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDVNICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDTNADIESKMVVNRATESGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKMNVPETMNEVLDMSDDEVGKASAPEKLSDGEYISDGEEGEDAITGDTDKYLGPQDLKELGDDSLPAEGYVGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLPFTREFDSDSLRHYSWAADTLDNVNLVSSPVHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLSELLNGMDEELDSPEELGTKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPEETVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPSLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLASQLYRELICVPYMAKFVVFAKTNDPVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKVRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKAEKADRRQSFTSLALRKRYSYLTEPSMKTVERSSGTARSLPTTYSHKPFFSTRPYQSWTTTPITVPGPAKSGSLSSSPSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDVASPIRSFRTISSPIRTVASPSPYNTQVASGTLGRVPTITEATPIKGVAPNSTLSSRTSPVTTAGSLLEKSSITMTPPASPKANITMYSSSLPFKSIITSAAPLISSPLKSVVSPTKSAADVISTAKAAMASTLSSPLKQMSGHAEVALVNGSVSPLKYPSSSALINGCKATATLQDKISTATNAVSSVVSAAPDTVEKALSTTTAMPFSPLRSYVSAAAPSAFQSLRAPSASALYNSLGPSVGVTTSSVTSSIITVPVYSVGNVLAEPALKKLPDSNSLTKSAAALLSPIKTLTTETRPQPHFNRTSSPVKSSLFLASSALKPSVPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQTDLPREGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVESKGPPKSPKSDKGHSPEDDWTEFSSEEIREARQAAASHAPSLPERVHGKANLTRVIDYLTNDIGSSSLTNLKYKFEEAKKEGEERQKRILKPAMALQEHKLKMPPASMRPSTSEKELCKMADSFFGTDAILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYEPSTGEIPQSQPEDPVSPKPPPTFMELEPKPTALSIKEKVKAFQMKASSEEEDHSRVLSKGMRVKEETHITTTTRMVYHSPPGSECASERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAMSPDVAKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGWQNETPSGSLESPAQARRITGGLLDRLDDSSDQVRDPITSYLTGEAGKFEANGNHAEVIPEAKAKAYFPESQNDIGKQSIKENLKPKTHGCGRAEEPVSPLTAYQKSLEETSKLVIEDAPKPCVPVGMKKMTRTPADGKARLNLQEEEGSARSEPKQGEGYKVKTKKEIRNVEKKAH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9 (in isoform 2)Phosphorylation-21373199
9 (in isoform 3)Phosphorylation-21373199
39PhosphorylationSRDRKKKSDANASYL
HHHHHHHHHHCHHHH
-
44PhosphorylationKKSDANASYLRAARA
HHHHHCHHHHHHHHH
28432305
70S-palmitoylationNGVDVNICNQNGLNA
CCCCEEEECCCCCCH
23129772
285AcetylationTPLHVASKRGNANMV
CCCHHHCCCCCCCHH
22902405
538PhosphorylationASPNAATTSGYTPLH
CCCCCCCCCCCCCCE
22673903
539PhosphorylationSPNAATTSGYTPLHL
CCCCCCCCCCCCCEE
22673903
541PhosphorylationNAATTSGYTPLHLSA
CCCCCCCCCCCEEEC
22673903
542PhosphorylationAATTSGYTPLHLSAR
CCCCCCCCCCEEECC
22673903
547PhosphorylationGYTPLHLSAREGHED
CCCCCEEECCCCCHH
22673903
583 (in isoform 4)Phosphorylation-28432305
583 (in isoform 5)Phosphorylation-28432305
583 (in isoform 6)Phosphorylation-28432305
583 (in isoform 7)Phosphorylation-28432305
585 (in isoform 4)Phosphorylation-28432305
585 (in isoform 5)Phosphorylation-28432305
585 (in isoform 6)Phosphorylation-28432305
585 (in isoform 7)Phosphorylation-28432305
586 (in isoform 4)Phosphorylation-28432305
586 (in isoform 5)Phosphorylation-28432305
586 (in isoform 6)Phosphorylation-28432305
586 (in isoform 7)Phosphorylation-28432305
593 (in isoform 4)Phosphorylation-28432305
593 (in isoform 5)Phosphorylation-28432305
593 (in isoform 6)Phosphorylation-28432305
593 (in isoform 7)Phosphorylation-28432305
598PhosphorylationLLLQKSASPDAAGKS
HHHHCCCCCCCCCCC
25403869
631PhosphorylationLLLDQGASPHAAAKN
EEECCCCCHHHHHHC
22108457
640PhosphorylationHAAAKNGYTPLHIAA
HHHHHCCCCHHHHHH
6964031
752 (in isoform 4)Phosphorylation-28432305
752 (in isoform 5)Phosphorylation-28432305
758 (in isoform 4)Phosphorylation-28432305
758 (in isoform 5)Phosphorylation-28432305
761 (in isoform 4)Phosphorylation-28432305
761 (in isoform 5)Phosphorylation-28432305
772PhosphorylationNAKTKNGYTPLHQAA
CCCCCCCCCHHHHHH
-
818PhosphorylationARRLGYISVVDTLKV
HHHHCCEEEEEHHHH
28432305
830 (in isoform 2)Phosphorylation-21373199
830 (in isoform 3)Phosphorylation-21373199
839 (in isoform 2)Phosphorylation-28551015
839 (in isoform 3)Phosphorylation-28551015
842 (in isoform 2)Phosphorylation-28551015
842 (in isoform 3)Phosphorylation-28551015
842 (in isoform 4)Phosphorylation-25575281
842 (in isoform 5)Phosphorylation-25575281
843 (in isoform 4)Phosphorylation-25575281
843 (in isoform 5)Phosphorylation-25575281
851 (in isoform 4)Phosphorylation-29779826
851 (in isoform 5)Phosphorylation-29779826
855PhosphorylationMNEVLDMSDDEVGKA
HHHHHCCCCCCCCCC
22108457
863PhosphorylationDDEVGKASAPEKLSD
CCCCCCCCCCCCCCC
28432305
869PhosphorylationASAPEKLSDGEYISD
CCCCCCCCCCCCCCC
29779826
873PhosphorylationEKLSDGEYISDGEEG
CCCCCCCCCCCCCCC
28551015
875PhosphorylationLSDGEYISDGEEGED
CCCCCCCCCCCCCCC
29779826
885PhosphorylationEEGEDAITGDTDKYL
CCCCCCCCCCCCCCC
28689409
888PhosphorylationEDAITGDTDKYLGPQ
CCCCCCCCCCCCCHH
28689409
899 (in isoform 4)Phosphorylation-26437020
899 (in isoform 5)Phosphorylation-26437020
900 (in isoform 4)Phosphorylation-26437020
900 (in isoform 5)Phosphorylation-26437020
905 (in isoform 7)Phosphorylation-24945867
908 (in isoform 4)Phosphorylation-26437020
908 (in isoform 5)Phosphorylation-26437020
910 (in isoform 4)Phosphorylation-26437020
910 (in isoform 5)Phosphorylation-26437020
910 (in isoform 7)Phosphorylation-24945867
912 (in isoform 4)Phosphorylation-28432305
912 (in isoform 5)Phosphorylation-28432305
915 (in isoform 4)Phosphorylation-28432305
915 (in isoform 5)Phosphorylation-28432305
919PhosphorylationGFSLGARSASLRSFS
CEECCCCCCCCCCCC
28432305
921PhosphorylationSLGARSASLRSFSSD
ECCCCCCCCCCCCCC
28432305
922 (in isoform 6)Phosphorylation-24945867
924PhosphorylationARSASLRSFSSDRSY
CCCCCCCCCCCCCCE
28432305
926PhosphorylationSASLRSFSSDRSYTL
CCCCCCCCCCCCEEC
22673903
927PhosphorylationASLRSFSSDRSYTLN
CCCCCCCCCCCEECC
28432305
927 (in isoform 6)Phosphorylation-24945867
930PhosphorylationRSFSSDRSYTLNRSS
CCCCCCCCEECCCCH
22673903
931PhosphorylationSFSSDRSYTLNRSSY
CCCCCCCEECCCCHH
22673903
932PhosphorylationFSSDRSYTLNRSSYA
CCCCCCEECCCCHHC
22673903
938PhosphorylationYTLNRSSYARDSMMI
EECCCCHHCCHHCCC
22108457
942PhosphorylationRSSYARDSMMIEELL
CCHHCCHHCCCEEHH
28432305
944 (in isoform 7)Phosphorylation--
961 (in isoform 6)Phosphorylation--
965PhosphorylationPFTREFDSDSLRHYS
CCCCCCCCCCCHHCC
25403869
967PhosphorylationTREFDSDSLRHYSWA
CCCCCCCCCHHCCCC
22108457
1097AcetylationSENGETWKEHQFDSK
CCCCCCHHHHCCCCC
22902405
1101 (in isoform 5)Phosphorylation-24945867
1106 (in isoform 5)Phosphorylation-24945867
1118 (in isoform 4)Phosphorylation-24945867
1121PhosphorylationGMDEELDSPEELGTK
CCCCCCCCHHHHCCH
28551015
1123 (in isoform 4)Phosphorylation-24945867
1140 (in isoform 5)Phosphorylation--
1157 (in isoform 4)Phosphorylation--
1181AcetylationFPEGALTKRIRVGLQ
CCCCCCCCCEEEEEE
22902405
1204AcetylationVKKILGNKATFSPIV
HHHHHCCCCCCCCCE
22902405
1378PhosphorylationKPIYVDCYGNLAPLT
CCEEEECCCCEECCC
31137051
1396PhosphorylationQQLVFNFYSFKENRL
EEEEEEEEEECCCCC
31137057
1408AcetylationNRLPFSIKVRDTSQE
CCCCEEEEECCCCCC
22902405
1411 (in isoform 2)Phosphorylation-28432305
1411 (in isoform 3)Phosphorylation-28432305
1412PhosphorylationFSIKVRDTSQEPCGR
EEEEECCCCCCCCCC
28432305
1413PhosphorylationSIKVRDTSQEPCGRL
EEEECCCCCCCCCCE
28432305
1413 (in isoform 2)Phosphorylation-28432305
1413 (in isoform 3)Phosphorylation-28432305
1414 (in isoform 2)Phosphorylation-28432305
1414 (in isoform 3)Phosphorylation-28432305
1421 (in isoform 2)Phosphorylation-28432305
1421 (in isoform 3)Phosphorylation-28432305
1427AcetylationLSFLKEPKTTKGLPQ
EEECCCCCCCCCCCC
22902405
1458PhosphorylationEKADRRQSFTSLALR
HHCHHHHCHHHHHHH
29779826
1460PhosphorylationADRRQSFTSLALRKR
CHHHHCHHHHHHHHH
28432305
1461PhosphorylationDRRQSFTSLALRKRY
HHHHCHHHHHHHHHH
28432305
1468PhosphorylationSLALRKRYSYLTEPS
HHHHHHHHHHHCCCC
27097102
1469PhosphorylationLALRKRYSYLTEPSM
HHHHHHHHHHCCCCC
27097102
1470PhosphorylationALRKRYSYLTEPSMK
HHHHHHHHHCCCCCC
27097102
1520O-linked_GlycosylationTVPGPAKSGSLSSSP
ECCCCCCCCCCCCCC
15578363
1543O-linked_GlycosylationLKSIWSVSTPSPIKS
CCCCCEECCCCCCCC
8516885
1544O-linked_GlycosylationKSIWSVSTPSPIKST
CCCCEECCCCCCCCC
8516849
1546O-linked_GlycosylationIWSVSTPSPIKSTLG
CCEECCCCCCCCCCC
8516843
1550PhosphorylationSTPSPIKSTLGASTT
CCCCCCCCCCCCCCC
28689409
1551PhosphorylationTPSPIKSTLGASTTS
CCCCCCCCCCCCCCC
28689409
1555O-linked_GlycosylationIKSTLGASTTSSVKS
CCCCCCCCCCCCCCC
31103777
1555PhosphorylationIKSTLGASTTSSVKS
CCCCCCCCCCCCCCC
28689409
1556O-linked_GlycosylationKSTLGASTTSSVKSI
CCCCCCCCCCCCCCH
8516837
1557O-linked_GlycosylationSTLGASTTSSVKSIS
CCCCCCCCCCCCCHH
8516827
1557PhosphorylationSTLGASTTSSVKSIS
CCCCCCCCCCCCCHH
28689409
1558O-linked_GlycosylationTLGASTTSSVKSISD
CCCCCCCCCCCCHHH
31103781
1559O-linked_GlycosylationLGASTTSSVKSISDV
CCCCCCCCCCCHHHC
31103779
1559PhosphorylationLGASTTSSVKSISDV
CCCCCCCCCCCHHHC
28689409
1580 (in isoform 2)Phosphorylation-28432305
1586 (in isoform 2)Phosphorylation-28432305
1589 (in isoform 2)Phosphorylation-28432305
1603O-linked_GlycosylationGTLGRVPTITEATPI
CCCCCCCCCCCCCCC
8516865
1605O-linked_GlycosylationLGRVPTITEATPIKG
CCCCCCCCCCCCCCC
8516893
1608O-linked_GlycosylationVPTITEATPIKGVAP
CCCCCCCCCCCCCCC
8516853
1617PhosphorylationIKGVAPNSTLSSRTS
CCCCCCCCCCCCCCC
28826663
1621PhosphorylationAPNSTLSSRTSPVTT
CCCCCCCCCCCCCCC
-
1624PhosphorylationSTLSSRTSPVTTAGS
CCCCCCCCCCCCCCH
-
1639PhosphorylationLLEKSSITMTPPASP
HHHHCCCCCCCCCCC
30181290
1641PhosphorylationEKSSITMTPPASPKA
HHCCCCCCCCCCCCC
30181290
1645PhosphorylationITMTPPASPKANITM
CCCCCCCCCCCCEEE
30181290
1670 (in isoform 2)Phosphorylation-25575281
1671 (in isoform 2)Phosphorylation-25575281
1679PhosphorylationSPLKSVVSPTKSAAD
CCHHHCCCCCCCHHH
73396901
1679 (in isoform 2)Phosphorylation-29779826
1681PhosphorylationLKSVVSPTKSAADVI
HHHCCCCCCCHHHHH
22673903
1683O-linked_GlycosylationSVVSPTKSAADVIST
HCCCCCCCHHHHHHH
50351819
1683PhosphorylationSVVSPTKSAADVIST
HCCCCCCCHHHHHHH
-
1689O-linked_GlycosylationKSAADVISTAKAAMA
CCHHHHHHHHHHHHH
50351823
1690O-linked_GlycosylationSAADVISTAKAAMAS
CHHHHHHHHHHHHHH
50351817
1727 (in isoform 2)Phosphorylation-26437020
1728 (in isoform 2)Phosphorylation-26437020
1736 (in isoform 2)Phosphorylation-26437020
1738 (in isoform 2)Phosphorylation-26437020
1740 (in isoform 2)Phosphorylation-28432305
1743 (in isoform 2)Phosphorylation-28432305
1751 (in isoform 3)Phosphorylation-24945867
1756 (in isoform 3)Phosphorylation-24945867
1768O-linked_GlycosylationTVEKALSTTTAMPFS
HHHHHHHCCCCCCCC
8516903
1790 (in isoform 3)Phosphorylation--
1854PhosphorylationKSAAALLSPIKTLTT
HHHHHHHHCHHHCCC
30240740
1929 (in isoform 2)Phosphorylation-24945867
1934 (in isoform 2)Phosphorylation-24945867
1968 (in isoform 2)Phosphorylation--
1984PhosphorylationPKSDKGHSPEDDWTE
CCCCCCCCCCCCCCC
30240740
2102PhosphorylationGTDAILESPDDFSQH
CCHHHHCCCCCHHHC
22673903
2107PhosphorylationLESPDDFSQHDQDKS
HCCCCCHHHCCCCCC
36751987
2114PhosphorylationSQHDQDKSPLSDSGF
HHCCCCCCCCCCCCC
22673903
2117PhosphorylationDQDKSPLSDSGFETR
CCCCCCCCCCCCCCC
22673903
2119PhosphorylationDKSPLSDSGFETRSE
CCCCCCCCCCCCCCC
22673903
2216PhosphorylationAFQMKASSEEEDHSR
HHHCCCCCCCHHHHH
25403869
2245PhosphorylationTTTTRMVYHSPPGSE
EEEEEEEEECCCCCH
25403869
2247PhosphorylationTTRMVYHSPPGSECA
EEEEEEECCCCCHHH
30240740
2331PhosphorylationHIEKGPQSPCERTDI
HHHCCCCCCCCCCCC
25403869
2385AcetylationSQSFMLLKKWVTRDG
HHHHHHHHHHHHCCC
22902405
2431PhosphorylationGNISGTRSFADENNV
CCCCCCCCCCCCCCC
24945867
2450PhosphorylationVDGWQNETPSGSLES
CCCCCCCCCCCCCCC
30181290
2452PhosphorylationGWQNETPSGSLESPA
CCCCCCCCCCCCCHH
30181290
2454PhosphorylationQNETPSGSLESPAQA
CCCCCCCCCCCHHHH
30181290
2457PhosphorylationTPSGSLESPAQARRI
CCCCCCCCHHHHHHH
27097102
2475PhosphorylationLLDRLDDSSDQVRDP
HHHHCCCCCHHHCCH
-
2516PhosphorylationAKAYFPESQNDIGKQ
HHHHCCCCCCCCCHH
28432305
2524PhosphorylationQNDIGKQSIKENLKP
CCCCCHHHHHHHCCC
28432305
2544PhosphorylationGRAEEPVSPLTAYQK
CCCCCCCCHHHHHHH
15953600
2547PhosphorylationEEPVSPLTAYQKSLE
CCCCCHHHHHHHHHH
25575281
2574AcetylationPCVPVGMKKMTRTPA
CCCCCCCCCCCCCCC
22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ANK3_RAT !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ANK3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ANK3_RAT !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ANK3_RAT !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ANK3_RAT

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Related Literatures of Post-Translational Modification

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