ANCHR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANCHR_MOUSE
• UniProt AC: Q9DAZ9
• Protein Name: Abscission/NoCut checkpoint regulator
• Gene Name: Zfyve19
• Organism: Mus musculus (Mouse).
• Sequence Length: 389
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cleavage furrow . Midbody, Midbody ring . Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cyto
• Protein Description: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity)..
• Protein Sequence: MESRCYGCAVKFTLFKKEYGCKNCGRAFCNGCLSFSALVPRAGNTQQKVCKQCHTILTRGSSDNASKWSPPQNYKKRVAALEAKKKSSTSHSQSLTHKDQAIAERLARLRQENKPKSVPSQAEIEARLAALKDEVQGPIPSTQEMEDRLAALQGRVPPSHTVRPAHQAPDTRTQAQQTQDLLTQLTAEVAIDENCQPRASASLQNDLNKGAARSQRTNSQGQASQSLEEEKYKLLAEAAVELQEENTRQERILALAKRLAVLKGQDPSRVTLQDYHLPDSDEDEETAIQRVMQQLTEEAALDEASGFNIPEKPAPGSRAQPCKAEMEGPQAEEEELPWCCICNEDATLRCAGCDGDLYCARCFREGHDNFDLKEHQTSPYHPRRPCQEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	HTILTRGSSDNASKW CHHHHCCCCCCHHHC		26643407
62	Phosphorylation	TILTRGSSDNASKWS HHHHCCCCCCHHHCC		26643407
66	Phosphorylation	RGSSDNASKWSPPQN CCCCCCHHHCCCCCC		25266776
69	Phosphorylation	SDNASKWSPPQNYKK CCCHHHCCCCCCHHH		27742792
74	Phosphorylation	KWSPPQNYKKRVAAL HCCCCCCHHHHHHHH		26643407
87	Phosphorylation	ALEAKKKSSTSHSQS HHHHHHHCCCCCHHH		29472430
88	Phosphorylation	LEAKKKSSTSHSQSL HHHHHHCCCCCHHHC		29472430
89	Phosphorylation	EAKKKSSTSHSQSLT HHHHHCCCCCHHHCC		29472430
92	Phosphorylation	KKSSTSHSQSLTHKD HHCCCCCHHHCCHHH		29472430
94	Phosphorylation	SSTSHSQSLTHKDQA CCCCCHHHCCHHHHH		25266776
96	Phosphorylation	TSHSQSLTHKDQAIA CCCHHHCCHHHHHHH		29472430
173	Phosphorylation	HQAPDTRTQAQQTQD CCCCCCHHHHHHHHH		25367039
178	Phosphorylation	TRTQAQQTQDLLTQL CHHHHHHHHHHHHHH		25367039
183	Phosphorylation	QQTQDLLTQLTAEVA HHHHHHHHHHHHHHH		25367039
186	Phosphorylation	QDLLTQLTAEVAIDE HHHHHHHHHHHHCCC		25367039
202	Phosphorylation	CQPRASASLQNDLNK CCCCCCHHHHCHHHH		27841257
214	Phosphorylation	LNKGAARSQRTNSQG HHHHHHHHHHHCCCC		22802335
217	Phosphorylation	GAARSQRTNSQGQAS HHHHHHHHCCCCCCC		27087446
219	Phosphorylation	ARSQRTNSQGQASQS HHHHHHCCCCCCCCC		25521595
224	Phosphorylation	TNSQGQASQSLEEEK HCCCCCCCCCHHHHH		26643407
226	Phosphorylation	SQGQASQSLEEEKYK CCCCCCCCHHHHHHH		26643407
231	Ubiquitination	SQSLEEEKYKLLAEA CCCHHHHHHHHHHHH		22790023
232	Phosphorylation	QSLEEEKYKLLAEAA CCHHHHHHHHHHHHH		24759943
271	Phosphorylation	GQDPSRVTLQDYHLP CCCCCCCEEEEECCC		25619855
275	Phosphorylation	SRVTLQDYHLPDSDE CCCEEEEECCCCCCC		25619855
280	Phosphorylation	QDYHLPDSDEDEETA EEECCCCCCCCHHHH		24925903
286	Phosphorylation	DSDEDEETAIQRVMQ CCCCCHHHHHHHHHH		25619855
377	Phosphorylation	FDLKEHQTSPYHPRR CCCCCCCCCCCCCCC		28066266
378	Phosphorylation	DLKEHQTSPYHPRRP CCCCCCCCCCCCCCC		25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANCHR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANCHR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANCHR_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ANCHR_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.