AN32E_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AN32E_RAT
• UniProt AC: Q5XIE0
• Protein Name: Acidic leucine-rich nuclear phosphoprotein 32 family member E
• Gene Name: Anp32e
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 258
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity)..
• Protein Sequence: MEMKKKINMELKNRAPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEEEDEDGDEDEEDEEEDEAGPPEGYEDEDEDEDEAGSEVGEGEEEVGLSYLMKEEIQDEEDDDDYVDEGEEEEEEEEEGPRGEKRKRDAEDDGEEDDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEMKKKIN -------CCCHHHHC	11.65	-
4	Acetylation	----MEMKKKINMEL ----CCCHHHHCHHH	37.29	22902405
5	Acetylation	---MEMKKKINMELK ---CCCHHHHCHHHH	58.54	22902405
6	Acetylation	--MEMKKKINMELKN --CCCHHHHCHHHHH	33.52	22902405
62	Phosphorylation	SSLARLPSLNKLRKL HHHCCCCCHHHHHCC	49.52	22673903
65	Acetylation	ARLPSLNKLRKLELS CCCCCHHHHHCCCCC	55.77	22902405
91	Phosphorylation	AEKCPNLTYLNLSGN HHHCCCCEEEECCCC	32.38	23984901
92	Phosphorylation	EKCPNLTYLNLSGNK HHCCCCEEEECCCCC	9.21	23984901
96	Phosphorylation	NLTYLNLSGNKIKDL CCEEEECCCCCCCCC	38.97	23984901
104	Phosphorylation	GNKIKDLSTVEALQN CCCCCCCHHHHHHHH	40.31	23984901
105	Phosphorylation	NKIKDLSTVEALQNL CCCCCCHHHHHHHHH	29.66	23984901
113	Acetylation	VEALQNLKNLKSLDL HHHHHHHHCCCCCCC	68.72	22902405
113	Ubiquitination	VEALQNLKNLKSLDL HHHHHHHHCCCCCCC	68.72	-
225	Phosphorylation	DEEDDDDYVDEGEEE CCCCCCCCCCCCHHH	19.45	22276854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AN32E_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AN32E_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AN32E_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AN32E_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.