AN13D_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AN13D_MOUSE
• UniProt AC: Q6PD24
• Protein Name: Ankyrin repeat domain-containing protein 13D
• Gene Name: Ankrd13d
• Organism: Mus musculus (Mouse).
• Sequence Length: 605
• Subcellular Localization: Cell membrane. Late endosome. Interaction with EGFR may enhance association with the cell membrane..
• Protein Description: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity)..
• Protein Sequence: MAGLGPTFPLHRLVWANRHRELEAALHSRKHDIEQEDPQGRTPLELAVTLGNLESVRVLLRHNANVGKESHQGWAVLQEAVSTGDPEMVQLVLQYRDFQRATQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMTWQRGRRSFIFRGQEAGALVMEVDHDRQVVHTETLAPALHEPEALLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMESVSGYEAKVYSATNVELVTRTRTEHLSDQDKLRNKGGKTPFQSFLGMAQQHSSHTLAPVQQAASPTNPTAISAEEYFDPSFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPVSSVCVPNSSSAISASGSPFPCEVDPTVFEVPEGYSVLGAERSEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALTNTRPGIHPPPRVTVFEEQLQLEQALQESLQLSTESRGPESPQKTPPSPAPPSFEEQLRLALELSSREQEELERRGQQEEDDLQRILQLSLTEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Ubiquitination	GIPELLNKLRQAPDF CHHHHHHHHHCCCCE	4.35	22790023
114	Ubiquitination	GIPELLNKLRQAPDF CHHHHHHHHHCCCCE	4.35	-
137	Phosphorylation	TSWVPLVSKMCPSDV CCHHHHHHHHCHHHH	27.08	20047950
246	Ubiquitination	NVAFERNKCGIWGWR CCCCCCCCCCCCCEE	51.74	22790023
246	Ubiquitination	NVAFERNKCGIWGWR CCCCCCCCCCCCCEE	51.74	-
256	Ubiquitination	IWGWRSEKMESVSGY CCCEECCCCCCCCCC	35.60	27667366
259	Phosphorylation	WRSEKMESVSGYEAK EECCCCCCCCCCEEE	4.87	23984901
261	Phosphorylation	SEKMESVSGYEAKVY CCCCCCCCCCEEEEE	25.81	23984901
263	Phosphorylation	KMESVSGYEAKVYSA CCCCCCCCEEEEEEE	7.17	23984901
268	Phosphorylation	SGYEAKVYSATNVEL CCCEEEEEEECCEEE	34.77	23984901
269	Phosphorylation	GYEAKVYSATNVELV CCEEEEEEECCEEEE	5.51	23984901
271	Phosphorylation	EAKVYSATNVELVTR EEEEEEECCEEEEEE	37.71	23984901
277	Phosphorylation	ATNVELVTRTRTEHL ECCEEEEEEECHHHC	8.09	23984901
355	Ubiquitination	RPIEMSSKVQRFKAT CCCCCHHHHHHHHEE	21.43	-
355	Ubiquitination	RPIEMSSKVQRFKAT CCCCCHHHHHHHHEE	21.43	22790023
409	Ubiquitination	LPPGFPVKIEIPLFH CCCCCCEEEEEEEEE	5.26	-
552	Phosphorylation	TESRGPESPQKTPPS CCCCCCCCCCCCCCC		25521595
555	Ubiquitination	RGPESPQKTPPSPAP CCCCCCCCCCCCCCC		22790023
555	Ubiquitination	RGPESPQKTPPSPAP CCCCCCCCCCCCCCC		-
556	Phosphorylation	GPESPQKTPPSPAPP CCCCCCCCCCCCCCC		25521595
559	Phosphorylation	SPQKTPPSPAPPSFE CCCCCCCCCCCCCHH		25619855
564	Phosphorylation	PPSPAPPSFEEQLRL CCCCCCCCHHHHHHH		113322997

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AN13D_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AN13D_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AN13D_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AN13D_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.