dbPTM

AMZ2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AMZ2_RAT
UniProt AC	Q400C7
Protein Name	Archaemetzincin-2
Gene Name	Amz2
Organism	Rattus norvegicus (Rat).
Sequence Length	359
Subcellular Localization
Protein Description	Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze neurogranin nor angiotensin-2 (By similarity)..
Protein Sequence	MQVLRHSEHTLKTALLSKNPDLVSQYEKLDAGEQRLMNEAFQPRNNLFEPITLHSQSDWISSHPEAPQDFEQFFSDRYRKAPCPKKHIIYIQPIGFLGNTRVISEEYIKWLKGYCEAFFYGLKVKFLEPVSVSATKCSFRVNENTQNLQIHTGHILAFLKRNKPEDAFCIVGITMIDLYPRDSWNFVFGQASLSSGVGIFSFARYGKDFYTSKYEGSVKVPQRTVSSDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHILGLRHCQWLACLMQGSNHLEESDRRPLNVCPICLRKLQSAIGFNIVERYKALVKWIDDESCGESGATPKSSSEHVYLPKPVEAFKDWREWILRCIAVLEK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
323	Phosphorylation	DDESCGESGATPKSS CCCCCCCCCCCCCCC	21.00	28432305
326	Phosphorylation	SCGESGATPKSSSEH CCCCCCCCCCCCCCC	34.47	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AMZ2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AMZ2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AMZ2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of AMZ2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AMZ2_RAT

Related Literatures of Post-Translational Modification