ALK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALK_MOUSE
• UniProt AC: P97793
• Protein Name: ALK tyrosine kinase receptor
• Gene Name: Alk
• Organism: Mus musculus (Mouse).
• Sequence Length: 1621
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway..
• Protein Description: Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK..
• Protein Sequence: MGAAGFLWLLPPLLLAAASYSGAATDQRAGSPASGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPQPRSPSEPEAGGLEARGSLALDCEPLLRLLGPLPGISWADGASSPSPEAGPTLSRVLKGGSVRKLRRAKQLVLELGEETILEGCIGPPEEVAAVGILQFNLSELFSWWILHGEGRLRIRLMPEKKASEVGREGRLSSAIRASQPRLLFQIFGTGHSSMESPSETPSPPGTFMWNLTWTMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHNHGNQSWSWRHVPSEEASRMNLLDGPEAEHSQEMPRGSFLLLNTSADSKHTILSPWMRSSSDHCTLAVSVHRHLQPSGRYVAQLLPHNEAGREILLVPTPGKHGWTVLQGRVGRPANPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDEGQLCSKLPAGFYCNFENGFCGWTQSPLSPHMPRWQVRTLRDAHSQGHQGRALLLSTTDILASEGATVTSATFPAPMKNSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQSRTVWHVATDEGLSLWQHTVLSLLDVTDRFWLQIVTWWGPGSRATVGFDNISISLDCYLTISGEEKMSLNSVPKSRNLFEKNPNKESKSWANISGPTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVVVGSEGPLKGVQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKGDTLYILVGQQGEDACPRANQLIQKVCVGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTETFHPERLESNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLLEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLADDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQPAKHEEASAAPQPAALTAPGPSVKKPPGAGAGAGAGAGAGPVPRGAADRGHVNMAFSQPNPPPELHKGPGSRNKPTSLWNPTYGSWFTEKPAKKTHPPPGAEPQARAGAAEGGWTGPGAGPRRAEAALLLEPSALSATMKEVPLFRLRHFPCGNVNYGYQQQGLPLEATAAPGDTMLKSKNKVTQPGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
174	N-linked_Glycosylation	AVGILQFNLSELFSW HHEEEEEEHHHHHHH	29.69	-
216	Phosphorylation	LSSAIRASQPRLLFQ HHHHHHHCCCEEEEE	30.76	66841
248	N-linked_Glycosylation	PPGTFMWNLTWTMKD CCCEEEEEEEEEECC	18.79	-
289	N-linked_Glycosylation	PPLHNHGNQSWSWRH CCCCCCCCCCCEEEC	25.76	-
328	N-linked_Glycosylation	RGSFLLLNTSADSKH CCCEEEEECCCCCCC	31.77	-
415	N-linked_Glycosylation	LEYISSGNRSLSAVD HHHHHCCCCEEEEEE	32.11	-
428	N-linked_Glycosylation	VDFFALKNCSEGTSP EEEEEECCCCCCCCC	35.08	-
449	N-linked_Glycosylation	QSSFTCWNGTVLQLG HCCEEEECCEEEECH	38.10	-
567	N-linked_Glycosylation	IRGVLRGNVSLVLVE HHHHHCCCEEEEEEE	17.48	-
569	Phosphorylation	GVLRGNVSLVLVENK HHHCCCEEEEEEECC	19.43	25338131
575	N-linked_Glycosylation	VSLVLVENKTGKEQS EEEEEEECCCCCCEE	39.44	-
577	Phosphorylation	LVLVENKTGKEQSRT EEEEECCCCCCEEEE	66.13	25338131
631	N-linked_Glycosylation	RATVGFDNISISLDC CCEECCCCEEEEEEE	27.87	-
673	N-linked_Glycosylation	KESKSWANISGPTPI CCCCCCCCCCCCCCC	23.77	-
713	N-linked_Glycosylation	NNAYQNSNLSVVVGS CCCCCCCCEEEEECC	43.83	-
812	N-linked_Glycosylation	IEEEIRVNRSVHEWA EEEEHHHCCCCCCCC	22.21	-
868	N-linked_Glycosylation	HPERLESNSSVLGLN CHHHHCCCCCEEECC	29.00	-
890	N-linked_Glycosylation	GGGGWNDNTSLLWAG CCCCCCCCCCEEECC	28.49	-
990	N-linked_Glycosylation	VNIKHYLNCSHCEVD EEEEEECCCCCCEEE	20.34	-
1082	Phosphorylation	MELQSPEYKLSKLRT HHHHCCHHHHHHHCC	22.18	21475
1089	Phosphorylation	YKLSKLRTSTIMTDY HHHHHHCCCCCCCCC	40.43	29899451
1096	Phosphorylation	TSTIMTDYNPNYCFA CCCCCCCCCCCCCCC	24.29	16878150
1100	Phosphorylation	MTDYNPNYCFAGKTS CCCCCCCCCCCCCCC	7.09	21479
1113	Acetylation	TSSISDLKEVPRKNI CCCHHHHHHCCCCCE	62.75	19843329
1135	Phosphorylation	HGAFGEVYEGQVSGM CCCCCEEEECCCCCC	15.27	-
1282	Phosphorylation	FGMARDIYRASYYRK CHHHHHHHHHHHHCC	12.38	-
1431	Phosphorylation	GMPPLLVSPQPAKHE CCCCEEECCCCCCCC	20.14	28066266
1516	Phosphorylation	TSLWNPTYGSWFTEK CCCCCCCCCCCCCCC	15.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALK_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHC1_MOUSE	Shc1	physical	15226403

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.