ALKB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALKB1_HUMAN
• UniProt AC: Q13686
• Protein Name: Nucleic acid dioxygenase ALKBH1 {ECO:0000305}
• Gene Name: ALKBH1 {ECO:0000312|HGNC:HGNC:17911}
• Organism: Homo sapiens (Human).
• Sequence Length: 389
• Subcellular Localization: Nucleus . Mitochondrion . Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli (By similarity).
• Protein Description: Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. [PubMed: 18603530]
• Protein Sequence: MGKMAAAVGSVATLATEPGEDAFRKLFRFYRQSRPGTADLEGVIDFSAAHAARGKGPGAQKVIKSQLNVSSVSEQNAYRAGLQPVSKWQAYGLKGYPGFIFIPNPFLPGYQWHWVKQCLKLYSQKPNVCNLDKHMSKEETQDLWEQSKEFLRYKEATKRRPRSLLEKLRWVTVGYHYNWDSKKYSADHYTPFPSDLGFLSEQVAAACGFEDFRAEAGILNYYRLDSTLGIHVDRSELDHSKPLLSFSFGQSAIFLLGGLQRDEAPTAMFMHSGDIMIMSGFSRLLNHAVPRVLPNPEGEGLPHCLEAPLPAVLPRDSMVEPCSMEDWQVCASYLKTARVNMTVRQVLATDQNFPLEPIEDEKRDISTEGFCHLDDQNSEVKRARINPDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Ubiquitination	GKGPGAQKVIKSQLN CCCCCHHHHHHHHHC	45.45	-
64	Ubiquitination	PGAQKVIKSQLNVSS CCHHHHHHHHHCCCC	34.83	-
87	Ubiquitination	AGLQPVSKWQAYGLK CCCCCCHHHHHCCCC	43.49	-
123	Phosphorylation	KQCLKLYSQKPNVCN HHHHHHHHCCCCCCC	42.01	68703615
125	Ubiquitination	CLKLYSQKPNVCNLD HHHHHHCCCCCCCHH	32.40	-
133	Ubiquitination	PNVCNLDKHMSKEET CCCCCHHHCCCHHHH	44.36	-
136	Phosphorylation	CNLDKHMSKEETQDL CCHHHCCCHHHHHHH	36.31	68703621
137	Ubiquitination	NLDKHMSKEETQDLW CHHHCCCHHHHHHHH	52.58	21906983
147	Phosphorylation	TQDLWEQSKEFLRYK HHHHHHHHHHHHHHH	23.72	68703627
148	Ubiquitination	QDLWEQSKEFLRYKE HHHHHHHHHHHHHHH	52.78	-
163	Phosphorylation	ATKRRPRSLLEKLRW HHHCCCHHHHHHCCE	39.73	24719451
189	Phosphorylation	KKYSADHYTPFPSDL CCEECCCCCCCCHHH	19.36	30576142
200	Phosphorylation	PSDLGFLSEQVAAAC CHHHHHHHHHHHHHC	24.58	30576142
240	Phosphorylation	DRSELDHSKPLLSFS CHHHCCCCCCEEEEE	35.32	24719451
362	Ubiquitination	LEPIEDEKRDISTEG CCCCCCCCCCCCCCC	68.63	2190698
381	Ubiquitination	DDQNSEVKRARINPD CCCCCCCCCCCCCCC	35.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALKB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALKB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALKB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNJB6_HUMAN	DNAJB6	physical	18163532

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.