ALFP2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALFP2_ARATH
• UniProt AC: Q944G9
• Protein Name: Fructose-bisphosphate aldolase 2, chloroplastic {ECO:0000305}
• Gene Name: FBA2 {ECO:0000303|PubMed:22561114}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 398
• Subcellular Localization: Plastid, chloroplast, plastoglobule . Plastid, chloroplast stroma .
• Protein Description: Plays a key role in glycolysis and gluconeogenesis..
• Protein Sequence: MASTSLLKASPVLDKSEWVKGQSVLFRQPSSASVVLRNRATSLTVRAASSYADELVKTAKTIASPGRGILAMDESNATCGKRLDSIGLENTEANRQAFRTLLVSAPGLGQYVSGAILFEETLYQSTTEGKKMVDVLVEQNIVPGIKVDKGLVPLVGSNNESWCQGLDGLSSRTAAYYQQGARFAKWRTVVSIPNGPSALAVKEAAWGLARYAAISQDSGLVPIVEPEILLDGEHDIDRTYDVAEKVWAEVFFYLAQNNVMFEGILLKPSMVTPGAESKDRATPEQVAAYTLKLLRNRVPPAVPGIMFLSGGQSEVEATLNLNAMNQAPNPWHVSFSYARALQNTCLKTWGGRPENVNAAQTTLLARAKANSLAQLGKYTGEGESEEAKEGMFVKGYTY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	SVLFRQPSSASVVLR EEEEECCCCCEEEEE		29654922
31	Phosphorylation	VLFRQPSSASVVLRN EEEECCCCCEEEEEC		25561503
49	Phosphorylation	SLTVRAASSYADELV CHHHHHHHHCHHHHH		30291188
50	Phosphorylation	LTVRAASSYADELVK HHHHHHHHCHHHHHH		29797451
58	Phosphorylation	YADELVKTAKTIASP CHHHHHHHHHHHCCC		25561503
61	Phosphorylation	ELVKTAKTIASPGRG HHHHHHHHHCCCCCC		19880383
64	Phosphorylation	KTAKTIASPGRGILA HHHHHHCCCCCCEEE		19880383
75	Phosphorylation	GILAMDESNATCGKR CEEEEECCCCCCCCC		30291188
78	Phosphorylation	AMDESNATCGKRLDS EEECCCCCCCCCHHH		23111157
85	Phosphorylation	TCGKRLDSIGLENTE CCCCCHHHHCCCCHH		30291188
91	Phosphorylation	DSIGLENTEANRQAF HHHCCCCHHHHHHHH		22092075
157	Phosphorylation	GLVPLVGSNNESWCQ CCEECCCCCCCCHHH		30291188
161	Phosphorylation	LVGSNNESWCQGLDG CCCCCCCCHHHCCCC		30291188
170	Phosphorylation	CQGLDGLSSRTAAYY HHCCCCCCHHHHHHH		30291188
176	Phosphorylation	LSSRTAAYYQQGARF CCHHHHHHHHHCCCC		24894044
188	Phosphorylation	ARFAKWRTVVSIPNG CCCCEEEEEEECCCC		22092075
211	Phosphorylation	AAWGLARYAAISQDS HHHHHHHHHHHHCCC		25368622
215	Phosphorylation	LARYAAISQDSGLVP HHHHHHHHCCCCCEE		25368622
218	Phosphorylation	YAAISQDSGLVPIVE HHHHHCCCCCEEECC		25368622
282	Phosphorylation	AESKDRATPEQVAAY CCCCCCCCHHHHHHH		28295753
289	Phosphorylation	TPEQVAAYTLKLLRN CHHHHHHHHHHHHHC		28295753
290	Phosphorylation	PEQVAAYTLKLLRNR HHHHHHHHHHHHHCC		22092075
371	Phosphorylation	LARAKANSLAQLGKY HHHHHHHHHHHHHCC		25561503
384	Phosphorylation	KYTGEGESEEAKEGM CCCCCCCCHHHHCCC		25561503
394	"N6,N6,N6-trimethyllysine"	AKEGMFVKGYTY--- HHCCCEECCCCC---		-
394	Methylation	AKEGMFVKGYTY--- HHCCCEECCCCC---		22547063
394	Acetylation	AKEGMFVKGYTY--- HHCCCEECCCCC---		21311031

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALFP2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
394	K	Methylation	Can be trimethylated at Lys-394 by LSMT-L.	22547063

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALFP2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ALFP2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.