ALFP1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALFP1_ARATH
• UniProt AC: Q9SJU4
• Protein Name: Fructose-bisphosphate aldolase 1, chloroplastic {ECO:0000305}
• Gene Name: FBA1 {ECO:0000303|PubMed:22561114}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 399
• Subcellular Localization: Plastid, chloroplast, plastoglobule . Plastid, chloroplast stroma .
• Protein Description: Plays a key role in glycolysis and gluconeogenesis..
• Protein Sequence: MASSTATMLKASPVKSDWVKGQSLLLRQPSSVSAIRSHVAPSALTVRAASAYADELVKTAKTIASPGHGIMAMDESNATCGKRLASIGLENTEANRQAYRTLLVSAPGLGQYISGAILFEETLYQSTTDGKKMVDVLVEQNIVPGIKVDKGLVPLVGSYDESWCQGLDGLASRTAAYYQQGARFAKWRTVVSIPNGPSALAVKEAAWGLARYAAISQDSGLVPIVEPEIMLDGEHGIDRTYDVAEKVWAEVFFYLAQNNVMFEGILLKPSMVTPGAEATDRATPEQVASYTLKLLRNRIPPAVPGIMFLSGGQSELEATLNLNAMNQAPNPWHVSFSYARALQNTCLKTWGGKEENVKAAQDILLARAKANSLAQLGKYTGEGESEEAKEGMFVKGYTY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	KTAKTIASPGHGIMA HHCHHHCCCCCCEEE		25561503
86	Phosphorylation	TCGKRLASIGLENTE CCCHHHHHHCCCCHH		30291188
92	Phosphorylation	ASIGLENTEANRQAY HHHCCCCHHHHHHHH		29797451
158	Phosphorylation	GLVPLVGSYDESWCQ CCCCCCCCCCCHHHH		30291188
177	Phosphorylation	LASRTAAYYQQGARF HHHHHHHHHHHCCCC		19880383
189	Phosphorylation	ARFAKWRTVVSIPNG CCCCEEEEEEECCCC		22092075
216	Phosphorylation	LARYAAISQDSGLVP HHHHHHHHCCCCCEE		22092075
289	Phosphorylation	ATPEQVASYTLKLLR CCHHHHHHHHHHHHH		28295753
290	Phosphorylation	TPEQVASYTLKLLRN CHHHHHHHHHHHHHC		28295753
291	Phosphorylation	PEQVASYTLKLLRNR HHHHHHHHHHHHHCC		28295753
372	Phosphorylation	LARAKANSLAQLGKY HHHHHHHHHHHHCCC		25561503
385	Phosphorylation	KYTGEGESEEAKEGM CCCCCCCCHHHHCCC		25561503
395	"N6,N6,N6-trimethyllysine"	AKEGMFVKGYTY--- HHCCCEECCCCC---		-
395	Acetylation	AKEGMFVKGYTY--- HHCCCEECCCCC---		-
395	Methylation	AKEGMFVKGYTY--- HHCCCEECCCCC---		22547063

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALFP1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
395	K	Methylation	Can be trimethylated at Lys-395 by LSMT-L, but the trimethylation has no effect in vitro on the kinetic properties of the enzyme.	22547063

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALFP1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ALFP1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.