ALDOA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALDOA_RAT
• UniProt AC: P05065
• Protein Name: Fructose-bisphosphate aldolase A
• Gene Name: Aldoa
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 364
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+)..
• Protein Description: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity)..
• Protein Sequence: MPHPYPALTPEQKKELADIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSSLAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACTQKFSNEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYIKRALANSLACQGKYTPSGQSGAAASESLFISNHAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MPHPYPALTPEQ ---CCCCCCCCCHHH	9.71	22673903
9	Phosphorylation	PHPYPALTPEQKKEL CCCCCCCCHHHHHHH	27.21	22673903
13	Acetylation	PALTPEQKKELADIA CCCCHHHHHHHHHHH	46.70	22902405
14	Acetylation	ALTPEQKKELADIAH CCCHHHHHHHHHHHH	58.62	22902405
14	Ubiquitination	ALTPEQKKELADIAH CCCHHHHHHHHHHHH	58.62	-
28	Acetylation	HRIVAPGKGILAADE HHHHCCCCCEEEEEC	41.54	22902405
28	Ubiquitination	HRIVAPGKGILAADE HHHHCCCCCEEEEEC	41.54	-
36	Phosphorylation	GILAADESTGSIAKR CEEEEECCHHHHHHH	38.32	23991683
37	Phosphorylation	ILAADESTGSIAKRL EEEEECCHHHHHHHH	32.66	27097102
39	Phosphorylation	AADESTGSIAKRLQS EEECCHHHHHHHHHH	21.33	23991683
42	Acetylation	ESTGSIAKRLQSIGT CCHHHHHHHHHHHCC	52.55	25786129
42	Ubiquitination	ESTGSIAKRLQSIGT CCHHHHHHHHHHHCC	52.55	-
46	Phosphorylation	SIAKRLQSIGTENTE HHHHHHHHHCCCCCH	27.81	28689409
49	Phosphorylation	KRLQSIGTENTEENR HHHHHHCCCCCHHHH	25.13	22673903
52	Phosphorylation	QSIGTENTEENRRFY HHHCCCCCHHHHHHH	38.14	22673903
65	Phosphorylation	FYRQLLLTADDRVNP HHHHHHHCCCCCCCH	28.19	174605
99	Other	RPFPQVIKSKGGVVG CCCCCCHHCCCCEEE	47.46	-
108	Ubiquitination	KGGVVGIKVDKGVVP CCCEEEEEECCCCEE	38.15	-
108	Acetylation	KGGVVGIKVDKGVVP CCCEEEEEECCCCEE	38.15	22902405
111	Ubiquitination	VVGIKVDKGVVPLAG EEEEEECCCCEECCC	57.50	-
111	Acetylation	VVGIKVDKGVVPLAG EEEEEECCCCEECCC	57.50	25786129
111	Malonylation	VVGIKVDKGVVPLAG EEEEEECCCCEECCC	57.50	-
111	N6-malonyllysine	VVGIKVDKGVVPLAG EEEEEECCCCEECCC	57.50	-
132	Phosphorylation	TQGLDGLSERCAQYK CCCCCHHHHHHHHHH	28.64	22673903
140	Ubiquitination	ERCAQYKKDGADFAK HHHHHHHHCCHHHHE	57.36	-
147	Ubiquitination	KDGADFAKWRCVLKI HCCHHHHEEEEEEEE	34.85	-
147	Acetylation	KDGADFAKWRCVLKI HCCHHHHEEEEEEEE	34.85	25786129
153	Ubiquitination	AKWRCVLKIGEHTPS HEEEEEEEECCCCHH	28.41	-
153	Acetylation	AKWRCVLKIGEHTPS HEEEEEEEECCCCHH	28.41	22902405
158	Phosphorylation	VLKIGEHTPSSLAIM EEEECCCCHHHCHHH	22.14	23984901
160	Phosphorylation	KIGEHTPSSLAIMEN EECCCCHHHCHHHHC	38.86	23984901
161	Phosphorylation	IGEHTPSSLAIMENA ECCCCHHHCHHHHCH	24.03	23984901
200	Ubiquitination	PDGDHDLKRCQYVTE CCCCCCHHHHHHHHH	58.13	-
200	Acetylation	PDGDHDLKRCQYVTE CCCCCCHHHHHHHHH	58.13	22902405
202	S-nitrosocysteine	GDHDLKRCQYVTEKV CCCCHHHHHHHHHHH	3.06	-
202	S-nitrosylation	GDHDLKRCQYVTEKV CCCCHHHHHHHHHHH	3.06	17629318
204	Phosphorylation	HDLKRCQYVTEKVLA CCHHHHHHHHHHHHH	16.99	174801
223	Phosphorylation	ALSDHHVYLEGTLLK HHCCCCEEEECEEEC	8.48	174165
227	Phosphorylation	HHVYLEGTLLKPNMV CCEEEECEEECCCCC	21.39	22673903
230	Acetylation	YLEGTLLKPNMVTPG EEECEEECCCCCCCC	37.14	22902405
243	Acetylation	PGHACTQKFSNEEIA CCCCCCCCCCCHHHH	32.38	26302492
245	Phosphorylation	HACTQKFSNEEIAMA CCCCCCCCCHHHHHH	50.82	22673903
253	Phosphorylation	NEEIAMATVTALRRT CHHHHHHHHHHHHHC	12.81	22673903
255	Phosphorylation	EIAMATVTALRRTVP HHHHHHHHHHHHCCC	18.67	22673903
269	Phosphorylation	PPAVPGVTFLSGGQS CCCCCCEEEECCCCC	25.44	22673903
272	Phosphorylation	VPGVTFLSGGQSEEE CCCEEEECCCCCHHH	36.36	11719147
276	Phosphorylation	TFLSGGQSEEEASIN EEECCCCCHHHHEEC	50.69	22673903
281	Phosphorylation	GQSEEEASINLNAIN CCCHHHHEECCCCCC	18.45	25403869
294	Acetylation	INKCPLLKPWALTFS CCCCCCCCCEEEEEE	46.31	22902405
309	Phosphorylation	YGRALQASALKAWGG HHHHHHHHHHHHCCC	22.60	54886787
312	Malonylation	ALQASALKAWGGKKE HHHHHHHHHCCCCHH	41.64	-
312	N6-malonyllysine	ALQASALKAWGGKKE HHHHHHHHHCCCCHH	41.64	-
312	Ubiquitination	ALQASALKAWGGKKE HHHHHHHHHCCCCHH	41.64	-
312	Acetylation	ALQASALKAWGGKKE HHHHHHHHHCCCCHH	41.64	22902405
317	Acetylation	ALKAWGGKKENLKAA HHHHCCCCHHHHHHH	53.64	22902405
318	Ubiquitination	LKAWGGKKENLKAAQ HHHCCCCHHHHHHHH	55.92	-
322	Ubiquitination	GGKKENLKAAQEEYI CCCHHHHHHHHHHHH	53.94	-
322	Acetylation	GGKKENLKAAQEEYI CCCHHHHHHHHHHHH	53.94	22902405
330	Ubiquitination	AAQEEYIKRALANSL HHHHHHHHHHHHHHH	30.62	-
330	Acetylation	AAQEEYIKRALANSL HHHHHHHHHHHHHHH	30.62	22902405
342	Acetylation	NSLACQGKYTPSGQS HHHHHCCCCCCCCCC	21.77	22902405
360	Phosphorylation	ASESLFISNHAY--- CCCCEEECCCCC---	18.41	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
46	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALDOA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALDOA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ALDOA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.