ALA4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALA4_ARATH
• UniProt AC: Q9LNQ4
• Protein Name: Probable phospholipid-transporting ATPase 4 {ECO:0000303|PubMed:11402198}
• Gene Name: ALA4 {ECO:0000303|PubMed:11402198}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1216
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Involved in transport of phospholipids..
• Protein Sequence: MARGRIRSKLRLSHIYTFGCLRPSADEGQDPHPIQGPGFSRTVYCNQPHMHKKKPLKYRSNYVSTTRYNLITFFPKCLYEQFHRAANFYFLVAAILSVFPLSPFNKWSMIAPLVFVVGLSMLKEALEDWSRFMQDVKINASKVYVHKSDGEFRRRKWKKISVGDIVKVEKDGFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRSLEVTLSLDDYDSFKDFTGIIRCEDPNPSLYTFVGNLEYERQIFPLDPSQILLRDSKLRNTPYVYGVVVFTGHDTKVMQNSTKSPSKRSRIEKTMDYIIYTLLVLLILISCISSSGFAWETKFHMPKWWYLRPEEPENLTNPSNPVYAGFVHLITALLLYGYLIPISLYVSIEVVKVLQASFINKDLHMYDSESGVPAHARTSNLNEELGQVDTILSDKTGTLTCNQMDFLKCSIAGTSYGVRSSEVEVAAAQQMAVDLDEHGEVSSRTSTPRAQARDIEVESSITPRIPIKGFGFEDIRLMDGNWLREPHTDDILLFFRILAICHTAIPELNEETGKYTYEAESPDEASFLTAASEFGFVFFKRTQSSVYVHERLSHSGQTIEREYKVLNLLDFTSKRKRMSVVVRDEEGQILLLCKGADSIIFERLAKNGKVYLGPTTKHLNEYGEAGLRTLALSYRKLDEEEYSAWNAEFHKAKTSIGSDRDELLERISDMIEKDLILVGATAVEDKLQKGVPQCIDKLAQAGLKLWVLTGDKMETAINIGYSCSLLRQGMKQICITVVNSEGASQDAKAVKDNILNQITKAVQMVKLEKDPHAAFALIIDGKTLTYALEDEMKYQFLALAVDCASVICCRVSPKQKALVTRLVKEGTGKITLAIGDGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHGHWCYKRIAQMICYFFYKNIAFGLTLFYFEAFTGFSGQSVYNDYYLLLFNVVLTSLPVIALGVFEQDVSSEICLQFPALYQQGKKNLFFDWYRILGWMGNGVYSSLVIFFLNIGIIYEQAFRVSGQTADMDAVGTTMFTCIIWAVNVQIALTVSHFTWIQHVLIWGSIGLWYLFVALYGMMPPSLSGNIYRILVEILAPAPIYWIATFLVTVTTVLPYFAHISFQRFLHPLDHHIIQEIKYYKRDVEDRRMWTRERTKAREKTKIGFTARVDAKIRHLRSKLNKKQSNMSQFSTQDTMSPRSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
441	Phosphorylation	QMDFLKCSIAGTSYG CCCEEECCCCCCCCC	17.56	25368622
445	Phosphorylation	LKCSIAGTSYGVRSS EECCCCCCCCCCCCH	15.11	25368622
446	Phosphorylation	KCSIAGTSYGVRSSE ECCCCCCCCCCCCHH	20.97	25368622
447	Phosphorylation	CSIAGTSYGVRSSEV CCCCCCCCCCCCHHH	21.34	25368622
674	Phosphorylation	KLDEEEYSAWNAEFH CCCHHHHHHHHHHHH	30.04	19376835
1200	Phosphorylation	SKLNKKQSNMSQFST HHHHHHHCCCCCCCC	43.30	30407730
1203	Phosphorylation	NKKQSNMSQFSTQDT HHHHCCCCCCCCCCC	32.12	25561503
1206	Phosphorylation	QSNMSQFSTQDTMSP HCCCCCCCCCCCCCC	19.95	25561503
1207	Phosphorylation	SNMSQFSTQDTMSPR CCCCCCCCCCCCCCC	31.58	25561503
1210	Phosphorylation	SQFSTQDTMSPRSV- CCCCCCCCCCCCCC-	15.10	25561503
1212	Phosphorylation	FSTQDTMSPRSV--- CCCCCCCCCCCC---	21.18	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALA4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALA4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALA4_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ALA4_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674, AND MASSSPECTROMETRY.
PubMed: 19376835