dbPTM

ALA3_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ALA3_ARATH
UniProt AC	Q9XIE6
Protein Name	Phospholipid-transporting ATPase 3 {ECO:0000303\|PubMed:11402198}
Gene Name	ALA3 {ECO:0000303\|PubMed:11402198}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1213
Subcellular Localization	Golgi apparatus membrane Multi-pass membrane protein . Endoplasmic reticulum membrane Multi-pass membrane protein . Requires the presence of an ALIS protein to exit the endoplasmic reticulum to the Golgi.
Protein Description	Involved in transport of phospholipids. Contributes to transmembrane flipping of lipids. Required for secretory processes during plant development. Requires an interaction with an ALIS protein for activity. Has activity with phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine, but not with lysolipid. [PubMed: 18344284]
Protein Sequence	MVRSGSFSVDSSATHQRTPSRTVTLGHIQPQAPTYRTVYCNDRESNQPVRFKGNSISTTKYNVFTFLPKGLFEQFRRIANIYFLGISCLSMTPISPVSPITNVAPLSMVLLVSLIKEAFEDWKRFQNDMSINNSTVEILQDQQWVSIPWRKLQVGDIVKIKKDGFFPADILFMSSTNSDGICYVETANLDGETNLKIRKALERTWDYLVPEKAYEFKGEIQCEQPNNSLYTFTGNLVVQKQTLPLSPDQLLLRGCSLRNTEYIVGAVVFTGHETKVMMNAMNAPSKRSTLEKKLDKLIITIFCVLVTMCLIGAIGCSIVTDREDKYLGLHNSDWEYRNGLMIGFFTFFTLVTLFSSIIPISLYVSIEMIKFIQSTQFINRDLNMYHAETNTPASARTSNLNEELGQVEYIFSDKTGTLTRNLMEFFKCSIGGVSYGCGVTEIEKGIAQRHGLKVQEEQRSTGAIREKGFNFDDPRLMRGAWRNEPNPDLCKELFRCLAICHTVLPEGDESPEKIVYQAASPDEAALVTAAKNFGFFFYRRTPTMVYVRESHVEKMGKIQDVAYEILNVLEFNSTRKRQSVVCRFPDGRLVLYCKGADNVIFERLANGMDDVRKVTREHLEHFGSSGLRTLCLAYKDLNPETYDSWNEKFIQAKSALRDREKKLDEVAELIEKDLILIGSTAIEDKLQEGVPTCIETLSRAGIKIWVLTGDKMETAINIAYACNLINNEMKQFVISSETDAIREAEERGDQVEIARVIKEEVKRELKKSLEEAQHSLHTVAGPKLSLVIDGKCLMYALDPSLRVMLLSLSLNCTSVVCCRVSPLQKAQVTSLVRKGAQKITLSIGDGANDVSMIQAAHVGIGISGMEGMQAVMASDFAIAQFRFLTDLLLVHGRWSYLRICKVVMYFFYKNLTFTLTQFWFTFRTGFSGQRFYDDWFQSLFNVVFTALPVIVLGLFEKDVSASLSKRYPELYREGIRNSFFKWRVVAVWATSAVYQSLVCYLFVTTSSFGAVNSSGKVFGLWDVSTMVFTCLVIAVNVRILLMSNSITRWHYITVGGSILAWLVFAFVYCGIMTPHDRNENVYFVIYVLMSTFYFYFTLLLVPIVSLLGDFIFQGVERWFFPYDYQIVQEIHRHESDASKADQLEVENELTPQEARSYAISQLPRELSKHTGFAFDSPGYESFFASQLGIYAPQKAWDVARRASMRSRPKVPKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVRSGSFSVDS ----CCCCCCEECCC	43.93	23111157
6	Phosphorylation	--MVRSGSFSVDSSA --CCCCCCEECCCCC	18.65	30407730
8	Phosphorylation	MVRSGSFSVDSSATH CCCCCCEECCCCCCC	27.06	25561503
22	Phosphorylation	HQRTPSRTVTLGHIQ CCCCCCCEEEECEEC	23.37	23111157
24	Phosphorylation	RTPSRTVTLGHIQPQ CCCCCEEEECEECCC	26.81	17317660
962	Phosphorylation	FEKDVSASLSKRYPE HHCCCCHHHHHHCHH	26.18	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ALA3_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ALA3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ALA3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ALA3_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ALA3_ARATH

Related Literatures of Post-Translational Modification