ALA10_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALA10_ARATH
• UniProt AC: Q9LI83
• Protein Name: Phospholipid-transporting ATPase 10 {ECO:0000303|PubMed:11402198}
• Gene Name: ALA10 {ECO:0000303|PubMed:11402198}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1202
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in transport of phospholipids..
• Protein Sequence: MAGPSRRRRRLHLSKIYSYTCGKSSFQEDHSNIGGPGFSRVVYCNEPGSPAAERRNYAGNYVRSTKYTVASFFPKSLFEQFRRVANFYFLVTGILSLTDLSPYGAVSALLPLALVISATMVKEGIEDWRRKQQDIEVNNRKVKVHDGNGIFRQEEWRNLRVGDIVRVEKDEFFPADLLLLSSSYEDSVCYVETMNLDGETNLKVKQGLEATSSLLNQDSDFKDFRGVVRCEDPNVNLYVFVGTLALEEERFPLSIQQILLRDSKLRNTEYVYGAVVFTGHDTKVIQNSTDPPSKRSRIERTMDKIIYLMFGLVFLMSFVGSIIFGVETREDKVKNGRTERWYLKPDDADIFFDPERAPMAAIYHFFTATMLYSYFIPISLYVSIEIVKVLQSIFINRDIHMYYEETDKPAQARTSNLNEELGMVDTILSDKTGTLTCNSMEFIKCSIAGKAYGRGITEVERAMAVRSGGSPLVNEDLDVVVDQSGPKVKGFNFEDERVMNGNWVRQPEAAVLQKFFRLLAVCHTAIPETDEESGNVSYEAESPDEAAFVVAAREFGFEFFNRTQNGISFRELDLVSGEKVERVYRLLNVLEFNSTRKRMSVIVRDDDGKLLLLSKGADNVMFERLAKNGRQFEAKTQEHVNQYADAGLRTLVLAYREVDENEYIEFNKSFNEAKASVSEDREALIDEITDKMERDLILLGATAVEDKLQNGVPECIDKLAQAGIKIWVLTGDKMETAINIGFASSLLRQEMKQIIINLETPQIKSLEKSGGKDEIELASRESVVMQLQEGKALLAASGASSEAFALIIDGKSLTYALEDEIKKMFLDLATSCASVICCRSSPKQKALVTRLVKSGTGKTTLAIGDGANDVGMLQEADIGVGISGVEGMQAVMSSDIAIAQFRYLERLLLVHGHWCYSRIASMICYFFYKNITFGVTVFLYEAYTSFSGQPAYNDWFLSLFNVFFSSLPVIALGVFDQDVSARFCYKFPLLYQEGVQNILFSWKRIIGWMFNGFISALAIFFLCKESLKHQLFDPDGKTAGREILGGTMYTCVVWVVNLQMALSISYFTWVQHIVIWGSIAFWYIFLMIYGAMTPSFSTDAYMVFLEALAPAPSYWLTTLFVMIFALIPYFVYKSVQMRFFPKYHQMIQWIRYEGHSNDPEFVEMVRQRSIRPTTVGYTARRAASVRRSARFHDQIYKDLVGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LHLSKIYSYTCGKSS HCHHHHHHHCCCCCC	19.89	25561503
25	Phosphorylation	SYTCGKSSFQEDHSN HHCCCCCCCCCCCCC	34.14	26811356
31	Phosphorylation	SSFQEDHSNIGGPGF CCCCCCCCCCCCCCC	42.33	17317660
301	Phosphorylation	KRSRIERTMDKIIYL HHHHHHHHHHHHHHH	19.55	24894044
467	Phosphorylation	ERAMAVRSGGSPLVN HHHHHHHCCCCCCCC	40.69	26811356
470	Phosphorylation	MAVRSGGSPLVNEDL HHHHCCCCCCCCCCC	20.70	17317660
814	Phosphorylation	IIDGKSLTYALEDEI EECCCCHHHHCHHHH	17.53	24243849
1169	Phosphorylation	VEMVRQRSIRPTTVG HHHHHHCCCCCCCHH	18.01	30407730
1173	Phosphorylation	RQRSIRPTTVGYTAR HHCCCCCCCHHHHHH	25.02	25561503
1174	Phosphorylation	QRSIRPTTVGYTARR HCCCCCCCHHHHHHH	18.02	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALA10_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALA10_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALA10_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ALA10_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Plant Cell 16:2394-2405(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, SUBCELLULARLOCATION, AND MASS SPECTROMETRY.
PubMed: 15308754

"Large-scale analysis of in vivo phosphorylated membrane proteins byimmobilized metal ion affinity chromatography and mass spectrometry.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Mol. Cell. Proteomics 2:1234-1243(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 14506206