AL3B1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AL3B1_RAT
• UniProt AC: Q5XI42
• Protein Name: Aldehyde dehydrogenase family 3 member B1
• Gene Name: Aldh3b1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 468
• Subcellular Localization: Cell membrane; Lipid-anchor. Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm..
• Protein Description: Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation..
• Protein Sequence: MDSFEDKLQQLREAFNAGRTRSAEFRAAQLQGLSHFLRDNKQQLQEALAQDLHKSAFESEVSEIAISQAEVDLALRNLRSWMKDEKVSKNLATQLDSAFIRKEPFGLVLIIVPWNYPLNLTLVPLVGAIAAGNCVVLKPSEISKATEKILAEVLPRYLDQSCFAVVLGGPQETGQLLEHRFDYIFFTGNTYVGKIVMAAAAKHLTPITLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSQEMQERLVPALQNAITRFYGDNPQTSPNLGRIINQKHFERLQGLLGCGRVAIGGQSDEGERYIAPTVLVDVQETEPVMQEEIFGPILPLVTVTNLDEAIEFINRREKPLALYAFSKRSQVIKQVLARTSSGGFCGNDGFMHMTLSSLPFGGVGTSGMGRYHGKFSFDTFSNQRACLLRSPGMEKINDLRYPPYTSRNLRVLLVAMEKRCCSCTLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSFEDKL -------CCHHHHHH	9.81	-
148	Ubiquitination	EISKATEKILAEVLP HHHHHHHHHHHHHHH	38.37	-
462	S-palmitoylation	LVAMEKRCCSCTLL- HHHHHHHHCCCCCC-	2.72	-
463	S-palmitoylation	VAMEKRCCSCTLL-- HHHHHHHCCCCCC--	4.32	-
465	Methylation	MEKRCCSCTLL---- HHHHHCCCCCC----	1.62	-
465	Geranylgeranylation	MEKRCCSCTLL---- HHHHHCCCCCC----	1.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AL3B1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AL3B1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AL3B1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AL3B1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.