AL3A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AL3A1_MOUSE
• UniProt AC: P47739
• Protein Name: Aldehyde dehydrogenase, dimeric NADP-preferring
• Gene Name: Aldh3a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 453
• Subcellular Localization: Cytoplasm .
• Protein Description: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. [PubMed: 25286108 Preferentially oxidizes aromatic aldehyde substrates]
• Protein Sequence: MSNISSIVNRARDAFNSGKTRPLQFRVEQLEALQRMINENLKGISKALASNLRKNEWTSYYEEVAHVLDEIDFTIKGLSDWAEDEPVAKTRQTQEDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAIAAGNAVVLKPSEVSDHMADLLSTLIPQYMDKDLYPVIKGGVPETTELLKEKFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNEIVEKLKKSLKDFYGEDAKQSHDYGRIINDRHFQRVINLIDSKKVAHGGTWDQPSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLDEAIKFINQREKPLALYVFSNNDKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVRSLRNEEANKARYPPSPAKMPRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSNISSIVN ------CCCHHHHHH	42.76	-
2	Phosphorylation	------MSNISSIVN ------CCCHHHHHH	42.76	23375375
5	Phosphorylation	---MSNISSIVNRAR ---CCCHHHHHHHHH	20.47	25338131
178	Acetylation	PETTELLKEKFDHIM CCHHHHHHHHCCCEE	72.05	-
194	Acetylation	TGSTAVGKIVMAAAA ECCHHHHHHHHHHHH	26.06	-
446	Phosphorylation	NKARYPPSPAKMPRH HHHCCCCCCCCCCCC	32.74	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AL3A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AL3A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AL3A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AL3A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.