AL1L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AL1L1_MOUSE
• UniProt AC: Q8R0Y6
• Protein Name: Cytosolic 10-formyltetrahydrofolate dehydrogenase
• Gene Name: Aldh1l1
• Organism: Mus musculus (Mouse).
• Sequence Length: 902
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MKIAVIGQSLFGQEVYCQLRKEGHEVVGVFTIPDKDGKADPLGLEAEKDGVPVFKFPRWRARGQALPEVVAKYQALGAELNVLPFCSQFIPMEVINAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTIFWADDGLDTGDLLLQKECDVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGTAPRRPQPEEGATYEGIQKKETAMINWDQPAEAIHNWIRGNDKVPGAWTEACGQKLTFFNSTLNTSGLVAQGEALPIPGAHRPGLVTKAGLILFGNDDRMLLVKNIQLEDGKMMPASQFFKGSASSALELTEEELATAEAVRSSWMRILPNVPEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMATTFGDFIQLLVRKLRGEDGESECVINYVEKAVKKLTLQMPYQLFIGGEFVDAEGAKTYSTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDQFVQKVVEEVGKMKIGNPLDRDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKTVTFEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	KIAVIGQSLFGQEVY CEEEEEHHHHCCEEE	22.06	23984901
17	S-nitrosylation	LFGQEVYCQLRKEGH HHCCEEEEEHHHCCC	3.57	22178444
17	S-palmitoylation	LFGQEVYCQLRKEGH HHCCEEEEEHHHCCC	3.57	26165157
21	Acetylation	EVYCQLRKEGHEVVG EEEEEHHHCCCEEEE	76.32	23954790
21	Malonylation	EVYCQLRKEGHEVVG EEEEEHHHCCCEEEE	76.32	26320211
21	Ubiquitination	EVYCQLRKEGHEVVG EEEEEHHHCCCEEEE	76.32	-
35	Acetylation	GVFTIPDKDGKADPL EEEEEECCCCCCCCC	64.13	23864654
35	Malonylation	GVFTIPDKDGKADPL EEEEEECCCCCCCCC	64.13	26320211
38	Acetylation	TIPDKDGKADPLGLE EEECCCCCCCCCCCC	60.80	23806337
38	Malonylation	TIPDKDGKADPLGLE EEECCCCCCCCCCCC	60.80	26320211
38	Succinylation	TIPDKDGKADPLGLE EEECCCCCCCCCCCC	60.80	-
38	Succinylation	TIPDKDGKADPLGLE EEECCCCCCCCCCCC	60.80	23806337
38	Ubiquitination	TIPDKDGKADPLGLE EEECCCCCCCCCCCC	60.80	27667366
48	Acetylation	PLGLEAEKDGVPVFK CCCCCCCCCCCEEEE	67.82	22733758
48	Malonylation	PLGLEAEKDGVPVFK CCCCCCCCCCCEEEE	67.82	26320211
48	Ubiquitination	PLGLEAEKDGVPVFK CCCCCCCCCCCEEEE	67.82	-
55	Ubiquitination	KDGVPVFKFPRWRAR CCCCEEEECCHHHCC	55.48	22790023
86	S-palmitoylation	ELNVLPFCSQFIPME CCCCHHHCCCCCCHH	2.70	28526873
128	Acetylation	WTLIHGDKKGGFTIF EEEEECCCCCCEEEE	58.89	23201123
128	Succinylation	WTLIHGDKKGGFTIF EEEEECCCCCCEEEE	58.89	23954790
128	Ubiquitination	WTLIHGDKKGGFTIF EEEEECCCCCCEEEE	58.89	-
129	Malonylation	TLIHGDKKGGFTIFW EEEECCCCCCEEEEE	69.84	25418362
152	S-palmitoylation	DLLLQKECDVLPDDT HHHEEECCCCCCCCH	5.89	28526873
159	Phosphorylation	CDVLPDDTVSTLYNR CCCCCCCHHHHHHHH	24.60	51459361
161	Phosphorylation	VLPDDTVSTLYNRFL CCCCCHHHHHHHHHH	18.13	51459377
162	Phosphorylation	LPDDTVSTLYNRFLF CCCCHHHHHHHHHHC	29.00	51459393
164	Phosphorylation	DDTVSTLYNRFLFPE CCHHHHHHHHHHCCH	12.36	51459401
174	Malonylation	FLFPEGIKGMVQAVR HHCCHHHHHHHHHHH	52.38	25418362
187	Phosphorylation	VRLIAEGTAPRRPQP HHHHHCCCCCCCCCC	25.62	28059163
200	Phosphorylation	QPEEGATYEGIQKKE CCCCCCCCCCCCCCE	16.18	17242355
205	Acetylation	ATYEGIQKKETAMIN CCCCCCCCCEEEECC	51.13	23201123
205	Malonylation	ATYEGIQKKETAMIN CCCCCCCCCEEEECC	51.13	26320211
205	Ubiquitination	ATYEGIQKKETAMIN CCCCCCCCCEEEECC	51.13	-
206	Malonylation	TYEGIQKKETAMINW CCCCCCCCEEEECCC	43.87	25418362
206	Ubiquitination	TYEGIQKKETAMINW CCCCCCCCEEEECCC	43.87	-
229	Acetylation	NWIRGNDKVPGAWTE HHHCCCCCCCCHHHH	55.09	23864654
229	Malonylation	NWIRGNDKVPGAWTE HHHCCCCCCCCHHHH	55.09	26320211
229	Ubiquitination	NWIRGNDKVPGAWTE HHHCCCCCCCCHHHH	55.09	-
238	S-palmitoylation	PGAWTEACGQKLTFF CCHHHHHHCCEEEEE	4.89	28526873
241	Malonylation	WTEACGQKLTFFNST HHHHHCCEEEEEECE	34.48	26073543
251	Phosphorylation	FFNSTLNTSGLVAQG EEECEECCCCCEECC	27.55	51459369
252	Phosphorylation	FNSTLNTSGLVAQGE EECEECCCCCEECCE	29.11	51459385
290	Acetylation	DDRMLLVKNIQLEDG CCCEEEEEEEEECCC	48.58	23954790
290	Malonylation	DDRMLLVKNIQLEDG CCCEEEEEEEEECCC	48.58	26320211
290	Ubiquitination	DDRMLLVKNIQLEDG CCCEEEEEEEEECCC	48.58	27667366
298	Acetylation	NIQLEDGKMMPASQF EEEECCCCEEEHHHH	44.33	23954790
298	Malonylation	NIQLEDGKMMPASQF EEEECCCCEEEHHHH	44.33	26320211
298	Ubiquitination	NIQLEDGKMMPASQF EEEECCCCEEEHHHH	44.33	27667366
303	Phosphorylation	DGKMMPASQFFKGSA CCCEEEHHHHCCCCC	22.96	23984901
307	Acetylation	MPASQFFKGSASSAL EEHHHHCCCCCCHHH	53.93	23954790
307	Malonylation	MPASQFFKGSASSAL EEHHHHCCCCCCHHH	53.93	26073543
309	Phosphorylation	ASQFFKGSASSALEL HHHHCCCCCCHHHHC	26.10	27180971
311	Phosphorylation	QFFKGSASSALELTE HHCCCCCCHHHHCCH	20.17	21743459
312	Phosphorylation	FFKGSASSALELTEE HCCCCCCHHHHCCHH	36.27	25521595
317	Phosphorylation	ASSALELTEEELATA CCHHHHCCHHHHHHH	31.79	23984901
323	Phosphorylation	LTEEELATAEAVRSS CCHHHHHHHHHHHHH	37.34	23567750
344	Phosphorylation	NVPEVEDSTDFFKSG CCCCCCCCCCHHHHC	19.17	23984901
345	Phosphorylation	VPEVEDSTDFFKSGA CCCCCCCCCHHHHCC	49.50	55993007
349	Ubiquitination	EDSTDFFKSGAASVD CCCCCHHHHCCCCHH	48.23	22790023
354	O-(pantetheine 4'-phosphoryl)serine	FFKSGAASVDVVRLV HHHHCCCCHHHHHHH	20.51	-
354	Phosphorylation	FFKSGAASVDVVRLV HHHHCCCCHHHHHHH	20.51	25521595
394	Ubiquitination	FIQLLVRKLRGEDGE HHHHHHHHHCCCCCC	34.75	22790023
402	Phosphorylation	LRGEDGESECVINYV HCCCCCCCHHHHHHH	41.65	55992481
404	S-nitrosylation	GEDGESECVINYVEK CCCCCCHHHHHHHHH	5.32	22178444
404	S-palmitoylation	GEDGESECVINYVEK CCCCCCHHHHHHHHH	5.32	28526873
411	Acetylation	CVINYVEKAVKKLTL HHHHHHHHHHHHHCC	48.73	22733758
411	Malonylation	CVINYVEKAVKKLTL HHHHHHHHHHHHHCC	48.73	26320211
411	Ubiquitination	CVINYVEKAVKKLTL HHHHHHHHHHHHHCC	48.73	-
415	Ubiquitination	YVEKAVKKLTLQMPY HHHHHHHHHCCCCCE	39.85	22790023
438	Phosphorylation	VDAEGAKTYSTINPT ECCCCCEEEEEECCC	23.36	23984901
439	Phosphorylation	DAEGAKTYSTINPTD CCCCCEEEEEECCCC	11.78	23984901
440	Phosphorylation	AEGAKTYSTINPTDG CCCCEEEEEECCCCC	28.22	23984901
441	Phosphorylation	EGAKTYSTINPTDGS CCCEEEEEECCCCCC	17.85	23984901
445	Phosphorylation	TYSTINPTDGSVICQ EEEEECCCCCCEEEE	48.80	23984901
448	Phosphorylation	TINPTDGSVICQVSL EECCCCCCEEEEEEE	15.89	23984901
454	Phosphorylation	GSVICQVSLAQVSDV CCEEEEEEEEECCCH	7.66	23984901
463	Acetylation	AQVSDVDKAVAAAKE EECCCHHHHHHHHHH	44.61	22733758
469	Acetylation	DKAVAAAKEAFENGL HHHHHHHHHHHHCCC	44.86	23954790
469	Ubiquitination	DKAVAAAKEAFENGL HHHHHHHHHHHHCCC	44.86	22790023
479	Acetylation	FENGLWGKINARDRG HHCCCCCCCCHHHHH	22.62	23954790
479	Malonylation	FENGLWGKINARDRG HHCCCCCCCCHHHHH	22.62	26320211
479	Ubiquitination	FENGLWGKINARDRG HHCCCCCCCCHHHHH	22.62	-
520	Malonylation	AVYTLALKTHVGMSI HHHHEEHHHCCCCCH	30.86	26073543
537	S-palmitoylation	FRYFAGWCDKIQGAT HHHHHHHHHHCCCEE	3.60	28526873
544	Phosphorylation	CDKIQGATIPINQAR HHHCCCEEEECCCCC	33.83	29472430
560	Acetylation	NRNLTLTKKEPVGVC CCCEEECCCCCCCEE	59.25	15618487
560	Ubiquitination	NRNLTLTKKEPVGVC CCCEEECCCCCCCEE	59.25	27667366
587	S-nitrosylation	LSWKTAACLAAGNTV CHHHHHHHHHCCCEE	2.17	22178444
587	S-palmitoylation	LSWKTAACLAAGNTV CHHHHHHHHHCCCEE	2.17	28526873
597	Ubiquitination	AGNTVVIKPAQVTPL CCCEEEECCCCCCCH	23.77	22790023
608	Acetylation	VTPLTALKFAELTLK CCCHHHHHHHHHHHH	39.81	23954790
608	Succinylation	VTPLTALKFAELTLK CCCHHHHHHHHHHHH	39.81	23954790
608	Ubiquitination	VTPLTALKFAELTLK CCCHHHHHHHHHHHH	39.81	-
615	Malonylation	KFAELTLKAGIPKGV HHHHHHHHCCCCCCC	39.05	26320211
615	Ubiquitination	KFAELTLKAGIPKGV HHHHHHHHCCCCCCC	39.05	27667366
620	Malonylation	TLKAGIPKGVVNILP HHHCCCCCCCEEECC	63.52	26320211
620	Ubiquitination	TLKAGIPKGVVNILP HHHCCCCCCCEEECC	63.52	27667366
629	Phosphorylation	VVNILPGSGSLVGQR CEEECCCCCCCCCCC	24.22	25521595
631	Phosphorylation	NILPGSGSLVGQRLS EECCCCCCCCCCCCC	22.91	21082442
638	Phosphorylation	SLVGQRLSDHPDVRK CCCCCCCCCCCCCCC	35.74	20469934
645	Ubiquitination	SDHPDVRKIGFTGST CCCCCCCCCCCCCCH	47.21	22790023
649	Phosphorylation	DVRKIGFTGSTEVGK CCCCCCCCCCHHHHH	25.63	22324799
651	Phosphorylation	RKIGFTGSTEVGKHI CCCCCCCCHHHHHHH	20.52	63810193
652	Phosphorylation	KIGFTGSTEVGKHIM CCCCCCCHHHHHHHH	35.71	29472430
656	Acetylation	TGSTEVGKHIMKSCA CCCHHHHHHHHHHHH	34.82	23954790
656	Malonylation	TGSTEVGKHIMKSCA CCCHHHHHHHHHHHH	34.82	26320211
656	Ubiquitination	TGSTEVGKHIMKSCA CCCHHHHHHHHHHHH	34.82	-
660	Acetylation	EVGKHIMKSCALSNV HHHHHHHHHHHHCCC	41.60	23201123
660	Malonylation	EVGKHIMKSCALSNV HHHHHHHHHHHHCCC	41.60	26320211
660	Succinylation	EVGKHIMKSCALSNV HHHHHHHHHHHHCCC	41.60	-
660	Ubiquitination	EVGKHIMKSCALSNV HHHHHHHHHHHHCCC	41.60	-
662	S-nitrosylation	GKHIMKSCALSNVKK HHHHHHHHHHCCCCE	3.54	22178444
662	S-palmitoylation	GKHIMKSCALSNVKK HHHHHHHHHHCCCCE	3.54	26165157
668	Ubiquitination	SCALSNVKKVSLELG HHHHCCCCEEEEECC	52.27	22790023
669	Malonylation	CALSNVKKVSLELGG HHHCCCCEEEEECCC	32.54	26320211
669	Ubiquitination	CALSNVKKVSLELGG HHHCCCCEEEEECCC	32.54	22790023
671	Phosphorylation	LSNVKKVSLELGGKS HCCCCEEEEECCCCC	25.63	27818261
677	Ubiquitination	VSLELGGKSPLIIFA EEEECCCCCCEEEEE	47.29	22790023
686	S-palmitoylation	PLIIFADCDLNKAVQ CEEEEEECCHHHHHH	6.02	28526873
703	Acetylation	MSSVFFNKGENCIAA CCHHEECCCCCEEEE	63.55	22733758
703	Ubiquitination	MSSVFFNKGENCIAA CCHHEECCCCCEEEE	63.55	22790023
726	Acetylation	IHDQFVQKVVEEVGK HHHHHHHHHHHHHHC	42.84	23954790
726	Ubiquitination	IHDQFVQKVVEEVGK HHHHHHHHHHHHHHC	42.84	22790023
733	Acetylation	KVVEEVGKMKIGNPL HHHHHHHCCCCCCCC	42.04	23954790
733	Malonylation	KVVEEVGKMKIGNPL HHHHHHHCCCCCCCC	42.04	26320211
735	Malonylation	VEEVGKMKIGNPLDR HHHHHCCCCCCCCCC	51.45	26320211
757	Malonylation	NHEAHLRKLVEYCQR CHHHHHHHHHHHHHH	64.34	26320211
757	Ubiquitination	NHEAHLRKLVEYCQR CHHHHHHHHHHHHHH	64.34	-
762	S-palmitoylation	LRKLVEYCQRGVKEG HHHHHHHHHHCHHCC	1.09	26165157
767	Acetylation	EYCQRGVKEGATLVC HHHHHCHHCCCEEEE	53.94	23806337
767	Malonylation	EYCQRGVKEGATLVC HHHHHCHHCCCEEEE	53.94	26320211
767	Succinylation	EYCQRGVKEGATLVC HHHHHCHHCCCEEEE	53.94	-
767	Succinylation	EYCQRGVKEGATLVC HHHHHCHHCCCEEEE	53.94	23806337
767	Ubiquitination	EYCQRGVKEGATLVC HHHHHCHHCCCEEEE	53.94	-
774	S-palmitoylation	KEGATLVCGGNQVPR HCCCEEEECCCCCCC	6.94	26165157
825	Phosphorylation	GDVDAVLSRANATEF CCHHHHHHHCCCCHH	23.81	-
845	Acetylation	VFTRDINKALYVSDK CEECCHHHHHEECCC	39.85	23954790
845	Malonylation	VFTRDINKALYVSDK CEECCHHHHHEECCC	39.85	26320211
845	Ubiquitination	VFTRDINKALYVSDK CEECCHHHHHEECCC	39.85	-
848	Phosphorylation	RDINKALYVSDKLQA CCHHHHHEECCCCCC	11.63	25195567
852	Acetylation	KALYVSDKLQAGTVF HHHEECCCCCCCEEE	34.69	23954790
852	Malonylation	KALYVSDKLQAGTVF HHHEECCCCCCCEEE	34.69	26073543
852	Ubiquitination	KALYVSDKLQAGTVF HHHEECCCCCCCEEE	34.69	-
865	Acetylation	VFVNTYNKTDVAAPF EEEEECCCCCCCCCC	35.37	22733758
865	Malonylation	VFVNTYNKTDVAAPF EEEEECCCCCCCCCC	35.37	26320211
865	Ubiquitination	VFVNTYNKTDVAAPF EEEEECCCCCCCCCC	35.37	27667366
876	Acetylation	AAPFGGFKQSGFGKD CCCCCCCCCCCCCCC	46.99	22733758
876	Malonylation	AAPFGGFKQSGFGKD CCCCCCCCCCCCCCC	46.99	26320211
876	Ubiquitination	AAPFGGFKQSGFGKD CCCCCCCCCCCCCCC	46.99	27667366
882	Acetylation	FKQSGFGKDLGEAAL CCCCCCCCCHHHHHH	47.74	23864654
882	Malonylation	FKQSGFGKDLGEAAL CCCCCCCCCHHHHHH	47.74	26320211
882	Ubiquitination	FKQSGFGKDLGEAAL CCCCCCCCCHHHHHH	47.74	-
892	Phosphorylation	GEAALNEYLRIKTVT HHHHHHHHEEEEEEE	10.54	55626819

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AL1L1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AL1L1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AL1L1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AL1L1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.