| UniProt ID | AKT1_CAEEL | |
|---|---|---|
| UniProt AC | Q17941 | |
| Protein Name | Serine/threonine-protein kinase akt-1 | |
| Gene Name | akt-1 | |
| Organism | Caenorhabditis elegans. | |
| Sequence Length | 541 | |
| Subcellular Localization | ||
| Protein Description | Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. [PubMed: 9716402] | |
| Protein Sequence | MSMTSLSTKSRRQEDVVIEGWLHKKGEHIRNWRPRYFMIFNDGALLGFRAKPKEGQPFPEPLNDFMIKDAATMLFEKPRPNMFMVRCLQWTTVIERTFYAESAEVRQRWIHAIESISKKYKGTNANPQEELMETNQQPKIDEDSEFAGAAHAIMGQPSSGHGDNCSIDFRASMISIADTSEAAKRDKITMEDFDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRLPFYSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFFRTVDWEATYRKEIEPPYKPNVQSETDTSYFDNEFTSQPVQLTPPSRSGALATVDEQEEMQSNFTQFSFHNVMGSINRIHEASEDNEDYDMG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSMTSLSTK ------CCCCCCCCC | 30.66 | 28854356 | |
| 172 | Phosphorylation | CSIDFRASMISIADT CCEEEEHHHEEECCC | 16.64 | 19530675 | |
| 175 | Phosphorylation | DFRASMISIADTSEA EEEHHHEEECCCHHH | 11.77 | 19530675 | |
| 179 | Phosphorylation | SMISIADTSEAAKRD HHEEECCCHHHHHHC | 21.31 | 19530675 | |
| 180 | Phosphorylation | MISIADTSEAAKRDK HEEECCCHHHHHHCC | 26.28 | 19530675 | |
| 350 | Phosphorylation | SFGDKTSTFCGTPEY ECCCCCCCCCCCCHH | 28.33 | 19249087 | |
| 485 | Phosphorylation | SYFDNEFTSQPVQLT CCCCCCCCCCCEECC | 21.92 | 19530675 | |
| 486 | Phosphorylation | YFDNEFTSQPVQLTP CCCCCCCCCCEECCC | 37.50 | 19530675 | |
| 492 | Phosphorylation | TSQPVQLTPPSRSGA CCCCEECCCCCCCCC | 18.96 | 19060867 | |
| 495 | Phosphorylation | PVQLTPPSRSGALAT CEECCCCCCCCCCEE | 40.04 | 19530675 | |
| 517 | Phosphorylation | QSNFTQFSFHNVMGS HHHCCHHHHHHHHHH | 18.77 | 19249087 | |
| 532 | Phosphorylation | INRIHEASEDNEDYD HHHHCHHCCCCCCCC | 42.36 | 19060867 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AKT1_CAEEL !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AKT1_CAEEL !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AKT1_CAEEL !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AKT1_CAEEL !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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