AKIR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKIR2_MOUSE
• UniProt AC: B1AXD8
• Protein Name: Akirin-2
• Gene Name: Akirin2 {ECO:0000303|PubMed:18066067}
• Organism: Mus musculus (Mouse).
• Sequence Length: 201
• Subcellular Localization: Nucleus .
• Protein Description: Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Required for embryonic development and the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6..
• Protein Sequence: MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQADPGCTSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MACGATLKRTLDF --CCCCCCCEECCCC	20.35	28576409
10	Phosphorylation	CGATLKRTLDFDPLL CCCCCEECCCCCCCC	29.14	25619855
18	Phosphorylation	LDFDPLLSPASPKRR CCCCCCCCCCCCCCC	26.55	21082442
21	Phosphorylation	DPLLSPASPKRRRCA CCCCCCCCCCCCCCC	34.05	25521595
31	Phosphorylation	RRRCAPLSAPASAAA CCCCCCCCCCHHHHC	31.02	25619855
35	Phosphorylation	APLSAPASAAASPAA CCCCCCHHHHCCHHH	19.85	25619855
39	Phosphorylation	APASAAASPAAATAA CCHHHHCCHHHHHHH	15.45	25619855
44	Phosphorylation	AASPAAATAAAAASA HCCHHHHHHHHHHHH	16.47	25619855
50	Phosphorylation	ATAAAAASAAAASPQ HHHHHHHHHHHHCHH	17.45	25619855
55	Phosphorylation	AASAAAASPQKYLRM HHHHHHHCHHHHHCC	24.12	26824392
99	Phosphorylation	KRRHLEASFQQADPG HHHHHHHHHHHCCCC	17.76	25293948
108	Phosphorylation	QQADPGCTSDSQPHA HHCCCCCCCCCCCCE	41.29	25293948
109	Phosphorylation	QADPGCTSDSQPHAF HCCCCCCCCCCCCEE	39.06	25293948
111	Phosphorylation	DPGCTSDSQPHAFLI CCCCCCCCCCCEEEE	45.43	25293948
119	Phosphorylation	QPHAFLISGPASPGT CCCEEEECCCCCCCC	40.65	25293948
123	Phosphorylation	FLISGPASPGTSSAT EEECCCCCCCCCCCC	27.31	26824392
126	Phosphorylation	SGPASPGTSSATSSP CCCCCCCCCCCCCCC	23.92	25293948
127	Phosphorylation	GPASPGTSSATSSPL CCCCCCCCCCCCCCC	24.72	26643407
128	Phosphorylation	PASPGTSSATSSPLK CCCCCCCCCCCCCCC	35.09	26643407
130	Phosphorylation	SPGTSSATSSPLKKE CCCCCCCCCCCCCCC	31.52	25293948
131	Phosphorylation	PGTSSATSSPLKKEQ CCCCCCCCCCCCCCC	29.67	26643407
132	Phosphorylation	GTSSATSSPLKKEQP CCCCCCCCCCCCCCC	29.87	26643407
184	Phosphorylation	YDAFVKFTHDQIMRR HHHHHHCCHHHHHHH	20.87	20139300

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKIR2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKIR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKIR2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AKIR2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.