AIF1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AIF1L_HUMAN
• UniProt AC: Q9BQI0
• Protein Name: Allograft inflammatory factor 1-like
• Gene Name: AIF1L
• Organism: Homo sapiens (Human).
• Sequence Length: 150
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria.
• Protein Description: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function..
• Protein Sequence: MSGELSNRFQGGKAFGLLKARQERRLAEINREFLCDQKYSDEENLPEKLTAFKEKYMEFDLNNEGEIDLMSLKRMMEKLGVPKTHLEMKKMISEVTGGVSDTISYRDFVNMMLGKRSAVLKLVMMFEGKANESSPKPVGPPPERDIASLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGELSNRF ------CCCCCCHHC	40.76	21406692
2	Acetylation	------MSGELSNRF ------CCCCCCHHC	40.76	21406692
2 (in isoform 2)	Phosphorylation	-	40.76	24719451
6	Phosphorylation	--MSGELSNRFQGGK --CCCCCCHHCCCCH	22.96	21406692
6 (in isoform 2)	Phosphorylation	-	22.96	27251275
8	Methylation	MSGELSNRFQGGKAF CCCCCCHHCCCCHHH	23.14	115368561
13 (in isoform 4)	Ubiquitination	-	47.57	21890473
13 (in isoform 3)	Ubiquitination	-	47.57	21890473
13 (in isoform 1)	Ubiquitination	-	47.57	21890473
13 (in isoform 2)	Ubiquitination	-	47.57	21890473
13	Ubiquitination	SNRFQGGKAFGLLKA CHHCCCCHHHHHHHH	47.57	32015554
13	Acetylation	SNRFQGGKAFGLLKA CHHCCCCHHHHHHHH	47.57	90925
19	Ubiquitination	GKAFGLLKARQERRL CHHHHHHHHHHHHHH	46.71	-
38	Ubiquitination	REFLCDQKYSDEENL HHHHHCCCCCCCCCC	33.21	32015554
40	Phosphorylation	FLCDQKYSDEENLPE HHHCCCCCCCCCCHH	45.65	-
48	Ubiquitination	DEENLPEKLTAFKEK CCCCCHHHHHHHHHH	49.55	29967540
56	Phosphorylation	LTAFKEKYMEFDLNN HHHHHHHHHCCCCCC	11.72	25690035
64	Ubiquitination	MEFDLNNEGEIDLMS HCCCCCCCCCCCHHH	58.07	32015554
74	Ubiquitination	IDLMSLKRMMEKLGV CCHHHHHHHHHHHCC	34.67	29967540
84	Phosphorylation	EKLGVPKTHLEMKKM HHHCCCHHHHHHHHH	26.14	23403867
133	Phosphorylation	FEGKANESSPKPVGP HCCCCCCCCCCCCCC	52.31	30266825
134	Phosphorylation	EGKANESSPKPVGPP CCCCCCCCCCCCCCC	30.66	30266825
148	Phosphorylation	PPERDIASLP----- CCCCCCCCCC-----	41.32	28102081
159 (in isoform 2)	Phosphorylation	-		21406692
160 (in isoform 2)	Phosphorylation	-		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AIF1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AIF1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AIF1L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AIF1L_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.