AGRG4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRG4_HUMAN
• UniProt AC: Q8IZF6
• Protein Name: Adhesion G-protein coupled receptor G4 {ECO:0000303|PubMed:25713288}
• Gene Name: ADGRG4
• Organism: Homo sapiens (Human).
• Sequence Length: 3080
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Orphan receptor..
• Protein Sequence: MKEHIIYQKLYGLILMSSFIFLSDTLSLKGKKLDFFGRGDTYVSLIDTIPELSRFTACIDLVFMDDNSRYWMAFSYITNNALLGREDIDLGLAGDHQQLILYRLGKTFSIRHHLASFQWHTICLIWDGVKGKLELFLNKERILEVTDQPHNLTPHGTLFLGHFLKNESSEVKSMMRSFPGSLYYFQLWDHILENEEFMKCLDGNIVSWEEDVWLVNKIIPTVDRTLRCFVPENMTIQEKSTTVSQQIDMTTPSQITGVKPQNTAHSSTLLSQSIPIFATDYTTISYSNTTSPPLETMTAQKILKTLVDETATFAVDVLSTSSAISLPTQSISIDNTTNSMKKTKSPSSESTKTTKMVEAMATEIFQPPTPSNFLSTSRFTKNSVVSTTSAIKSQSAVTKTTSLFSTIESTSMSTTPCLKQKSTNTGALPISTAGQEFIESTAAGTVPWFTVEKTSPASTHVGTASSFPPEPVLISTAAPVDSVFPRNQTAFPLATTDMKIAFTVHSLTLPTRLIETTPAPRTAETELTSTNFQDVSLPRVEDAMSTSMSKETSSKTFSFLTSFSFTGTESVQTVIDAEATRTALTPEITLASTVAETMLSSTITGRVYTQNTPTADGHLLTLMSTRSASTSKAPESGPTSTTDEAAHLFSSNETIWTSRPDQALLASMNTTTILTFVPNENFTSAFHENTTYTEYLSATTNITPLKASPEGKGTTANDATTARYTTAVSKLTSPWFANFSIVSGTTSITNMPEFKLTTLLLKTIPMSTKPANELPLTPRETVVPSVDIISTLACIQPNFSTEESASETTQTEINGAIVFGGTTTPVPKSATTQRLNATVTRKEATSHYLMRKSTIAAVAEVSPFSTMLEVTDESAQRVTASVTVSSFPDIEKLSTPLDNKTATTEVRESWLLTKLVKTTPRSSYNEMTEMFNFNHTYVAHWTSETSEGISAGSPTSGSTHIFGEPLGASTTRISETSFSTTPTDRTATSLSDGILPPQPTAAHSSATPVPVTHMFSLPVNGSSVVAEETEVTMSEPSTLARAFSTSVLSDVSNLSSTTMTTALVPPLDQTASTTIVIVPTHGDLIRTTSEATVISVRKTSMAVPSLTETPFHSLRLSTPVTAKAETTLFSTSVDTVTPSTHTLVCSKPPPDNIPPASSTHVISTTSTPEATQPISQVEETSTYALSFPYTFSGGGVVASLATGTTETSVVDETTPSHISANKLTTSVNSHISSSATYRVHTPVSIQLVTSTSVLSSDKDQMTISLGKTPRTMEVTEMSPSKNSFISYSRGTPSLEMTDTGFPETTKISSHQTHSPSEIPLGTPSDGNLASSPTSGSTQITPTLTSSNTVGVHIPEMSTSLGKTALPSQALTITTFLCPEKESTSALPAYTPRTVEMIVNSTYVTHSVSYGQDTSFVDTTTSSSTRISNPMDINTTFSHLHSLRTQPEVTSVASFISESTQTFPESLSLSTAGLYNDGFTVLSDRITTAFSVPNVPTMLPRESSMATSTPIYQMSSLPVNVTAFTSKKVSDTPPIVITKSSKTMHPGCLKSPCTATSGPMSEMSSIPVNNSAFTPATVSSDTSTRVGLFSTLLSSVTPRTTMTMQTSTLDVTPVIYAGATSKNKMVSSAFTTEMIEAPSRITPTTFLSPTEPTLPFVKTVPTTIMAGIVTPFVGTTAFSPLSSKSTGAISSIPKTTFSPFLSATQQSSQADEATTLGILSGITNRSLSTVNSGTGVALTDTYSRITVPENMLSPTHADSLHTSFNIQVSPSLTSFKSASGPTKNVKTTTNCFSSNTRKMTSLLEKTSLTNYATSLNTPVSYPPWTPSSATLPSLTSFVYSPHSTEAEISTPKTSPPPTSQMVEFPVLGTRMTSSNTQPLLMTSWNIPTAEGSQFPISTTINVPTSNEMETETLHLVPGPLSTFTASQTGLVSKDVMAMSSIPMSGILPNHGLSENPSLSTSLRAITSTLADVKHTFEKMTTSVTPGTTLPSILSGATSGSVISKSPILTWLLSSLPSGSPPATVSNAPHVMTSSTVEVSKSTFLTSDMISAHPFTNLTTLPSATMSTILTRTIPTPTLGGITTGFPTSLPMSINVTDDIVYISTHPEASSRTTITANPRTVSHPSSFSRKTMSPSTTDHTLSVGAMPLPSSTITSSWNRIPTASSPSTLIIPKPTLDSLLNIMTTTSTVPGASFPLISTGVTYPFTATVSSPISSFFETTWLDSTPSFLSTEASTSPTATKSTVSFYNVEMSFSVFVEEPRIPITSVINEFTENSLNSIFQNSEFSLATLETQIKSRDISEEEMVMDRAILEQREGQEMATISYVPYSCVCQVIIKASSSLASSELMRKIKSKIHGNFTHGNFTQDQLTLLVNCEHVAVKKLEPGNCKADETASKYKGTYKWLLTNPTETAQTRCIKNEDGNATRFCSISINTGKSQWEKPKFKQCKLLQELPDKIVDLANITISDENAEDVAEHILNLINESPALGKEETKIIVSKISDISQCDEISMNLTHVMLQIINVVLEKQNNSASDLHEISNEILRIIERTGHKMEFSGQIANLTVAGLALAVLRGDHTFDGMAFSIHSYEEGTDPEIFLGNVPVGGILASIYLPKSLTERIPLSNLQTILFNFFGQTSLFKTKNVTKALTTYVVSASISDDMFIQNLADPVVITLQHIGGNQNYGQVHCAFWDFENNNGLGGWNSSGCKVKETNVNYTICQCDHLTHFGVLMDLSRSTVDSVNEQILALITYTGCGISSIFLGVAVVTYIAFHKLRKDYPAKILINLCTALLMLNLVFLINSWLSSFQKVGVCITAAVALHYFLLVSFTWMGLEAVHMYLALVKVFNIYIPNYILKFCLVGWGIPAIMVAITVSVKKDLYGTLSPTTPFCWIKDDSIFYISVVAYFCLIFLMNLSMFCTVLVQLNSVKSQIQKTRRKMILHDLKGTMSLTFLLGLTWGFAFFAWGPMRNFFLYLFAIFNTLQGFFIFVFHCVMKESVREQWQIHLCCGWLRLDNSSDGSSRCQIKVGYKQEGLKKIFEHKLLTPSLKSTATSSTFKSLGSAQGTPSEISFPNDDFDKDPYCSSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
233	N-linked_Glycosylation	LRCFVPENMTIQEKS EECCCCCCCEEECCC		UniProtKB CARBOHYD
242	Phosphorylation	TIQEKSTTVSQQIDM EEECCCCCHHHEEEC		27174698
244	Phosphorylation	QEKSTTVSQQIDMTT ECCCCCHHHEEECCC		27174698
250	Phosphorylation	VSQQIDMTTPSQITG HHHEEECCCHHHCCC		27174698
251	Phosphorylation	SQQIDMTTPSQITGV HHEEECCCHHHCCCC		27174698
253	Phosphorylation	QIDMTTPSQITGVKP EEECCCHHHCCCCCC		27174698
256	Phosphorylation	MTTPSQITGVKPQNT CCCHHHCCCCCCCCC		27174698
383	Phosphorylation	TSRFTKNSVVSTTSA CCCCCCCCEEECCHH		26074081
386	Phosphorylation	FTKNSVVSTTSAIKS CCCCCEEECCHHHHC		26074081
387	Phosphorylation	TKNSVVSTTSAIKSQ CCCCEEECCHHHHCC		26074081
388	Phosphorylation	KNSVVSTTSAIKSQS CCCEEECCHHHHCCC		26074081
389	Phosphorylation	NSVVSTTSAIKSQSA CCEEECCHHHHCCCC		26074081
393	Phosphorylation	STTSAIKSQSAVTKT ECCHHHHCCCCCCCC		26074081
395	Phosphorylation	TSAIKSQSAVTKTTS CHHHHCCCCCCCCCC		26074081
398	Phosphorylation	IKSQSAVTKTTSLFS HHCCCCCCCCCCCCH		26074081
402	Phosphorylation	SAVTKTTSLFSTIES CCCCCCCCCCHHEEC		30576142
410	Phosphorylation	LFSTIESTSMSTTPC CCHHEECCCCCCCCC		22210691
411	Phosphorylation	FSTIESTSMSTTPCL CHHEECCCCCCCCCC		22210691
413	Phosphorylation	TIESTSMSTTPCLKQ HEECCCCCCCCCCCC		22210691
414	Phosphorylation	IESTSMSTTPCLKQK EECCCCCCCCCCCCC		22210691
415	Phosphorylation	ESTSMSTTPCLKQKS ECCCCCCCCCCCCCC		30576142
487	N-linked_Glycosylation	VDSVFPRNQTAFPLA CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
503	Phosphorylation	TDMKIAFTVHSLTLP CCCEEEEEEEECCCC		-
511	Phosphorylation	VHSLTLPTRLIETTP EEECCCCCEEEECCC		-
536	Phosphorylation	STNFQDVSLPRVEDA CCCCCCCCCCCHHHH		24719451
609	Phosphorylation	TITGRVYTQNTPTAD CCCCCEEECCCCCCC		25690035
624	Phosphorylation	GHLLTLMSTRSASTS CEEEEEEEECCCCCC		25690035
721	Phosphorylation	TTANDATTARYTTAV CCCCCCCHHHHCHHH		-
724	Phosphorylation	NDATTARYTTAVSKL CCCCHHHHCHHHHHC		24260401
725	Phosphorylation	DATTARYTTAVSKLT CCCHHHHCHHHHHCC		24260401
726	Phosphorylation	ATTARYTTAVSKLTS CCHHHHCHHHHHCCC		24260401
743	Phosphorylation	FANFSIVSGTTSITN CCCEEEEECCCCCCC		27251275
745	Phosphorylation	NFSIVSGTTSITNMP CEEEEECCCCCCCCC		27251275
746	Phosphorylation	FSIVSGTTSITNMPE EEEEECCCCCCCCCC		24719451
747	Phosphorylation	SIVSGTTSITNMPEF EEEECCCCCCCCCCC		24719451
749	Phosphorylation	VSGTTSITNMPEFKL EECCCCCCCCCCCHH		27251275
829	Phosphorylation	TTTPVPKSATTQRLN CCCCCCCCCCCCCEE		22468782
836	N-linked_Glycosylation	SATTQRLNATVTRKE CCCCCCEEEEEEHHH		UniProtKB CARBOHYD
840	Phosphorylation	QRLNATVTRKEATSH CCEEEEEEHHHHHHH		22468782
842	Ubiquitination	LNATVTRKEATSHYL EEEEEEHHHHHHHHH		29967540
854	Phosphorylation	HYLMRKSTIAAVAEV HHHHHHHHHHHEEEC		24719451
899	N-linked_Glycosylation	KLSTPLDNKTATTEV HCCCCCCCCCCCHHH		UniProtKB CARBOHYD
974	Phosphorylation	GASTTRISETSFSTT CCCCCEEEECCCCCC		30206219
976	Phosphorylation	STTRISETSFSTTPT CCCEEEECCCCCCCC		30206219
977	Phosphorylation	TTRISETSFSTTPTD CCEEEECCCCCCCCC		30206219
979	Phosphorylation	RISETSFSTTPTDRT EEEECCCCCCCCCCC		30206219
980	Phosphorylation	ISETSFSTTPTDRTA EEECCCCCCCCCCCC		30206219
981	Phosphorylation	SETSFSTTPTDRTAT EECCCCCCCCCCCCC		30206219
983	Phosphorylation	TSFSTTPTDRTATSL CCCCCCCCCCCCCCC		30206219
1020	N-linked_Glycosylation	HMFSLPVNGSSVVAE EEEECEECCCCEEEE		UniProtKB CARBOHYD
1055	Phosphorylation	LSDVSNLSSTTMTTA HHCHHCCCCCCCEEE		26074081
1056	Phosphorylation	SDVSNLSSTTMTTAL HCHHCCCCCCCEEEC		26074081
1057	Phosphorylation	DVSNLSSTTMTTALV CHHCCCCCCCEEECC		26074081
1058	Phosphorylation	VSNLSSTTMTTALVP HHCCCCCCCEEECCC		26074081
1060	Phosphorylation	NLSSTTMTTALVPPL CCCCCCCEEECCCCC		26074081
1105	Phosphorylation	KTSMAVPSLTETPFH ECCCCCCCCCCCCCC		-
1237	Phosphorylation	HISSSATYRVHTPVS CCCCCCEEEECCCEE		-
1241	Phosphorylation	SATYRVHTPVSIQLV CCEEEECCCEEEEEE		-
1250	Phosphorylation	VSIQLVTSTSVLSSD EEEEEEEEEEECCCC		-
1251	Phosphorylation	SIQLVTSTSVLSSDK EEEEEEEEEECCCCC		-
1278	Phosphorylation	TMEVTEMSPSKNSFI EEEEEEECCCCCCCE		-
1382	Phosphorylation	FLCPEKESTSALPAY EECCCCCCCCCCCCC		-
1390	Phosphorylation	TSALPAYTPRTVEMI CCCCCCCCCCEEEEE		-
1393	Phosphorylation	LPAYTPRTVEMIVNS CCCCCCCEEEEEEEC		24043423
1400	Phosphorylation	TVEMIVNSTYVTHSV EEEEEEECCEEEEEE		24043423
1401	Phosphorylation	VEMIVNSTYVTHSVS EEEEEECCEEEEEEE		24043423
1402	Phosphorylation	EMIVNSTYVTHSVSY EEEEECCEEEEEEEC		24043423
1404	Phosphorylation	IVNSTYVTHSVSYGQ EEECCEEEEEEECCC		24043423
1406	Phosphorylation	NSTYVTHSVSYGQDT ECCEEEEEEECCCCC		24043423
1408	Phosphorylation	TYVTHSVSYGQDTSF CEEEEEEECCCCCCC		24043423
1409	Phosphorylation	YVTHSVSYGQDTSFV EEEEEEECCCCCCCE		24043423
1413	Phosphorylation	SVSYGQDTSFVDTTT EEECCCCCCCEEECC		24043423
1414	Phosphorylation	VSYGQDTSFVDTTTS EECCCCCCCEEECCC		24043423
1418	Phosphorylation	QDTSFVDTTTSSSTR CCCCCEEECCCCCCC		24043423
1419	Phosphorylation	DTSFVDTTTSSSTRI CCCCEEECCCCCCCC		24043423
1420	Phosphorylation	TSFVDTTTSSSTRIS CCCEEECCCCCCCCC		24043423
1421	Phosphorylation	SFVDTTTSSSTRISN CCEEECCCCCCCCCC		24043423
1422	Phosphorylation	FVDTTTSSSTRISNP CEEECCCCCCCCCCC		24043423
1423	Phosphorylation	VDTTTSSSTRISNPM EEECCCCCCCCCCCC		24043423
1424	Phosphorylation	DTTTSSSTRISNPMD EECCCCCCCCCCCCC		24043423
1486	Phosphorylation	TVLSDRITTAFSVPN EEECCCEEECCCCCC		30576142
1506	Phosphorylation	PRESSMATSTPIYQM CCCCCCCCCCCCEEC		30576142
1519	N-linked_Glycosylation	QMSSLPVNVTAFTSK ECCCCCCEEEEEECC		UniProtKB CARBOHYD
1524	Phosphorylation	PVNVTAFTSKKVSDT CCEEEEEECCCCCCC		30576142
1541	Ubiquitination	IVITKSSKTMHPGCL EEEECCCCCCCCCCC		-
1555	Phosphorylation	LKSPCTATSGPMSEM CCCCCCCCCCCHHHC		-
1556	Phosphorylation	KSPCTATSGPMSEMS CCCCCCCCCCHHHCC		-
1674	Phosphorylation	IVTPFVGTTAFSPLS CCCCCCCCCCCCCCC		30576142
1678	Phosphorylation	FVGTTAFSPLSSKST CCCCCCCCCCCCCCC		30576142
1694	Phosphorylation	AISSIPKTTFSPFLS CCCCCCCCCCCCCCC		-
1695	Phosphorylation	ISSIPKTTFSPFLSA CCCCCCCCCCCCCCC		-
1742	Phosphorylation	VALTDTYSRITVPEN EEECCCCCCCCCCCC		-
1800	Phosphorylation	SNTRKMTSLLEKTSL CCHHHHHHHHHHHCC		24719451
1965	Phosphorylation	STSLRAITSTLADVK HHHHHHHHHHHHHHH		-
1966	Phosphorylation	TSLRAITSTLADVKH HHHHHHHHHHHHHHH		-
1967	Phosphorylation	SLRAITSTLADVKHT HHHHHHHHHHHHHHH		-
2004	Phosphorylation	SGSVISKSPILTWLL CCCCCCCCHHHHHHH		26552605
2008	Phosphorylation	ISKSPILTWLLSSLP CCCCHHHHHHHHCCC		26552605
2012	Phosphorylation	PILTWLLSSLPSGSP HHHHHHHHCCCCCCC		26552605
2013	Phosphorylation	ILTWLLSSLPSGSPP HHHHHHHCCCCCCCC		26552605
2016	Phosphorylation	WLLSSLPSGSPPATV HHHHCCCCCCCCCCC		26552605
2018	Phosphorylation	LSSLPSGSPPATVSN HHCCCCCCCCCCCCC		26552605
2022	Phosphorylation	PSGSPPATVSNAPHV CCCCCCCCCCCCCCC		26552605
2024	Phosphorylation	GSPPATVSNAPHVMT CCCCCCCCCCCCCCC		26552605
2031	Phosphorylation	SNAPHVMTSSTVEVS CCCCCCCCCCEEEEE		26552605
2032	Phosphorylation	NAPHVMTSSTVEVSK CCCCCCCCCEEEEEC		26552605
2033	Phosphorylation	APHVMTSSTVEVSKS CCCCCCCCEEEEECH		26552605
2034	Phosphorylation	PHVMTSSTVEVSKST CCCCCCCEEEEECHH		26552605
2038	Phosphorylation	TSSTVEVSKSTFLTS CCCEEEEECHHEECC		26552605
2114	Phosphorylation	ASSRTTITANPRTVS CCCCCEECCCCCCCC		-
2119	Phosphorylation	TITANPRTVSHPSSF EECCCCCCCCCCCCC		-
2125	Phosphorylation	RTVSHPSSFSRKTMS CCCCCCCCCCCCCCC		17081983
2130	Phosphorylation	PSSFSRKTMSPSTTD CCCCCCCCCCCCCCC		-
2150	Phosphorylation	GAMPLPSSTITSSWN CCEECCCCCCCCCCC		-
2361	N-linked_Glycosylation	HGNFTHGNFTQDQLT CCCCCCCCCCHHHEE		UniProtKB CARBOHYD
2528	Phosphorylation	VLEKQNNSASDLHEI HHHHCCCCHHHHHHH		-
2620	Phosphorylation	LTERIPLSNLQTILF HHCCCCCCHHCHHHH		-
2624	Phosphorylation	IPLSNLQTILFNFFG CCCCHHCHHHHHHCC		-
2634	Phosphorylation	FNFFGQTSLFKTKNV HHHCCCCCCCCCCCH		24719451
2638	Phosphorylation	GQTSLFKTKNVTKAL CCCCCCCCCCHHHHH		-
2640	N-linked_Glycosylation	TSLFKTKNVTKALTT CCCCCCCCHHHHHHE		UniProtKB CARBOHYD
2733	Phosphorylation	VLMDLSRSTVDSVNE HCCCCCHHHHHHHHH		26552605
2734	Phosphorylation	LMDLSRSTVDSVNEQ CCCCCHHHHHHHHHH		26552605
2737	Phosphorylation	LSRSTVDSVNEQILA CCHHHHHHHHHHHHH		26552605
2747	Phosphorylation	EQILALITYTGCGIS HHHHHHHHHCCCCHH		26552605
2748	Phosphorylation	QILALITYTGCGISS HHHHHHHHCCCCHHH		26552605
2749	Phosphorylation	ILALITYTGCGISSI HHHHHHHCCCCHHHH		26552605
2754	Phosphorylation	TYTGCGISSIFLGVA HHCCCCHHHHHHHHH		26552605
2755	Phosphorylation	YTGCGISSIFLGVAV HCCCCHHHHHHHHHH		26552605
2764	Phosphorylation	FLGVAVVTYIAFHKL HHHHHHHHHHHHHHH		26552605
2765	Phosphorylation	LGVAVVTYIAFHKLR HHHHHHHHHHHHHHC		26552605
2785	Phosphorylation	KILINLCTALLMLNL HHHHHHHHHHHHHHH		-
2876	Phosphorylation	VSVKKDLYGTLSPTT EEECHHHCCCCCCCC		29759185
2878	Phosphorylation	VKKDLYGTLSPTTPF ECHHHCCCCCCCCCC		29759185
2880	Phosphorylation	KDLYGTLSPTTPFCW HHHCCCCCCCCCCEE		29759185
2922	Phosphorylation	TVLVQLNSVKSQIQK HHHHHHHHHHHHHHH		24719451
2930	Phosphorylation	VKSQIQKTRRKMILH HHHHHHHHHHHHHHH		19664995
3011	Phosphorylation	GWLRLDNSSDGSSRC EEEEECCCCCCCCCE		24667141
3012	Phosphorylation	WLRLDNSSDGSSRCQ EEEECCCCCCCCCEE		24667141
3015	Phosphorylation	LDNSSDGSSRCQIKV ECCCCCCCCCEEEEE		28122231
3039	Phosphorylation	IFEHKLLTPSLKSTA HHHCCCCCHHHCCCC		25072903
3041	Phosphorylation	EHKLLTPSLKSTATS HCCCCCHHHCCCCCC		25072903
3044	Phosphorylation	LLTPSLKSTATSSTF CCCHHHCCCCCCHHH		25072903
3045	Phosphorylation	LTPSLKSTATSSTFK CCHHHCCCCCCHHHH		25072903
3047	Phosphorylation	PSLKSTATSSTFKSL HHHCCCCCCHHHHHC		25072903
3048	Phosphorylation	SLKSTATSSTFKSLG HHCCCCCCHHHHHCC		25072903
3049	Phosphorylation	LKSTATSSTFKSLGS HCCCCCCHHHHHCCC		25072903
3050	Phosphorylation	KSTATSSTFKSLGSA CCCCCCHHHHHCCCC		25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRG4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRG4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRG4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AGRG4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.