AGRF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRF3_HUMAN
• UniProt AC: Q8IZF5
• Protein Name: Adhesion G-protein coupled receptor F3
• Gene Name: ADGRF3
• Organism: Homo sapiens (Human).
• Sequence Length: 1079
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Orphan receptor..
• Protein Sequence: MVCSAAPLLLLATTLPLLGSPVAQASQPVSETGVRPREGLQRRQWGPLIGRDKAWNERIDRPFPACPIPLSSSFGRWPKGQTMWAQTSTLTLTEEELGQSQAGGESGSGQLLDQENGAGESALVSVYVHLDFPDKTWPPELSRTLTLPAASASSSPRPLLTGLRLTTECNVNHKGNFYCACLSGYQWNTSICLHYPPCQSLHNHQPCGCLVFSHPEPGYCQLLPPGSPVTCLPAVPGILNLNSQLQMPGDTLSLTLHLSQEATNLSWFLRHPGSPSPILLQPGTQVSVTSSHGQAALSVSNMSHHWAGEYMSCFEAQGFKWNLYEVVRVPLKATDVARLPYQLSISCATSPGFQLSCCIPSTNLAYTAAWSPGEGSKASSFNESGSQCFVLAVQRCPMADTTYACDLQSLGLAPLRVPISITIIQDGDITCPEDASVLTWNVTKAGHVAQAPCPESKRGIVRRLCGADGVWGPVHSSCTDARLLALFTRTKLLQAGQGSPAEEVPQILAQLPGQAAEASSPSDLLTLLSTMKYVAKVVAEARIQLDRRALKNLLIATDKVLDMDTRSLWTLAQARKPWAGSTLLLAVETLACSLCPQDHPFAFSLPNVLLQSQLFGPTFPADYSISFPTRPPLQAQIPRHSLAPLVRNGTEISITSLVLRKLDHLLPSNYGQGLGDSLYATPGLVLVISIMAGDRAFSQGEVIMDFGNTDGSPHCVFWDHSLFQGRGGWSKEGCQAQVASASPTAQCLCQHLTAFSVLMSPHTVPEEPALALLTQVGLGASILALLVCLGVYWLVWRVVVRNKISYFRHAALLNMVFCLLAADTCFLGAPFLSPGPRSPLCLAAAFLCHFLYLATFFWMLAQALVLAHQLLFVFHQLAKHRVLPLMVLLGYLCPLGLAGVTLGLYLPQGQYLREGECWLDGKGGALYTFVGPVLAIIGVNGLVLAMAMLKLLRPSLSEGPPAEKRQALLGVIKALLILTPIFGLTWGLGLATLLEEVSTVPHYIFTILNTLQGVFILLFGCLMDRKIQEALRKRFCRAQAPSSTISLVSCCLQILSCASKSMSEGIPWPSSEDMGTARS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	PACPIPLSSSFGRWP CCCCCCCCCCCCCCC		-
142	Phosphorylation	KTWPPELSRTLTLPA CCCCHHHHCCEECCC		-
146	Phosphorylation	PELSRTLTLPAASAS HHHHCCEECCCCCCC		-
154	Phosphorylation	LPAASASSSPRPLLT CCCCCCCCCCCCCEE		-
161	Phosphorylation	SSPRPLLTGLRLTTE CCCCCCEECCEEECE		24719451
188	N-linked_Glycosylation	CLSGYQWNTSICLHY EECCCCCCCEEEEEC		UniProtKB CARBOHYD
264	N-linked_Glycosylation	HLSQEATNLSWFLRH EHHHHHHCHHHHHCC		UniProtKB CARBOHYD
301	N-linked_Glycosylation	QAALSVSNMSHHWAG EEEEEEECCCCCCCC		UniProtKB CARBOHYD
382	N-linked_Glycosylation	GSKASSFNESGSQCF CCCCCCCCCCCCEEE		UniProtKB CARBOHYD
441	N-linked_Glycosylation	DASVLTWNVTKAGHV CCCEEEEEEEECCCC		UniProtKB CARBOHYD
557	Phosphorylation	LKNLLIATDKVLDMD HHHHHHHCCCCCCCC		-
641	Phosphorylation	QAQIPRHSLAPLVRN CCCCCHHHCHHHHCC		22210691
648	N-linked_Glycosylation	SLAPLVRNGTEISIT HCHHHHCCCCEEEEH		UniProtKB CARBOHYD
655	Phosphorylation	NGTEISITSLVLRKL CCCEEEEHHHHHHHH		22210691
973 (in isoform 3)	Phosphorylation	-		-
1063	Phosphorylation	SCASKSMSEGIPWPS HHHHHCHHCCCCCCC		-
1076	Phosphorylation	PSSEDMGTARS---- CCCCCCCCCCC----		-
1079	Phosphorylation	EDMGTARS------- CCCCCCCC-------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRF3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AGRF3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.