AGRB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRB3_HUMAN
• UniProt AC: O60242
• Protein Name: Adhesion G protein-coupled receptor B3 {ECO:0000303|PubMed:25713288}
• Gene Name: ADGRB3 {ECO:0000312|HGNC:HGNC:945}
• Organism: Homo sapiens (Human).
• Sequence Length: 1522
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1. [PubMed: 24567399]
• Protein Sequence: MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSVSEMFPKNFTNCTWTLENPDPTKYSIYLKFSKKDLSCSNFSLLAYQFDHFSHEKIKDLLRKNHSIMQLCNSKNAFVFLQYDKNFIQIRRVFPTNFPGLQKKGEEDQKSFFEFLVLNKVSPSQFGCHVLCTWLESCLKSENGRTESCGIMYTKCTCPQHLGEWGIDDQSLILLNNVVLPLNEQTEGCLTQELQTTQVCNLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESGVEEWSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCNEQRCPAPYEICPEDYLMSMVWKRTPAGDLAFNQCPLNATGTTSRRCSLSLHGVAFWEQPSFARCISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTKTLLDLTQRKNFYAGDLLMSVEILRNVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEKWEDAQQIYPGSIELMQVIEDFIHIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINFPMKGRKGMVDWARNSEDRVVIPKSIFTPVSSKELDESSVFVLGAVLYKNLDLILPTLRNYTVINSKIIVVTIRPEPKTTDSFLEIELAHLANGTLNPYCVLWDDSKTNESLGTWSTQGCKTVLTDASHTKCLCDRLSTFAILAQQPREIIMESSGTPSVTLIVGSGLSCLALITLAVVYAALWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVLTEAWQSYMAVTGKIRTRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVLHKDIGPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPMSMNELSNPCLKKENSELRRTVYLCTDDNLRGADMDIVHPQERMMESDYIVMPRSSVNNQPSMKEESKMNIGMETLPHERLLHYKVNPEFNMNPPVMDQFNMNLEQHLAPQEHMQNLPFEPRTAVKNFMASELDDNAGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHMELFQELNQKFQTLDRFRDIPNTSSMENPAPNKNPWDTFKNPSEYPHYTTINVLDTEAKDALELRPAEWEKCLNLPLDVQEGDFQTEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	VSEMFPKNFTNCTWT HHHHCCCCCCCCEEE		UniProtKB CARBOHYD
53	Phosphorylation	EMFPKNFTNCTWTLE HHCCCCCCCCEEEEC		-
54	N-linked_Glycosylation	MFPKNFTNCTWTLEN HCCCCCCCCEEEECC		UniProtKB CARBOHYD
67	Phosphorylation	ENPDPTKYSIYLKFS CCCCCCCEEEEEEEE		25332170
70	Phosphorylation	DPTKYSIYLKFSKKD CCCCEEEEEEEECCC		25332170
82	N-linked_Glycosylation	KKDLSCSNFSLLAYQ CCCCCCCCCHHHHHH		UniProtKB CARBOHYD
105	N-linked_Glycosylation	IKDLLRKNHSIMQLC HHHHHHHCCCHHHHH		UniProtKB CARBOHYD
241	N-linked_Glycosylation	LQTTQVCNLTREAKR HHHHHHHHCCCCCCC		UniProtKB CARBOHYD
261	Phosphorylation	FGMMGDHTIKSQRPR CCCCCCCCCCCCCCC		28348404
337	N-linked_Glycosylation	LRESRVCNNTALCPV CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
418	N-linked_Glycosylation	QCSVTCSNGTQQRSR CCEEECCCCCCEEEE		UniProtKB CARBOHYD
540	N-linked_Glycosylation	AFNQCPLNATGTTSR CCCCCCCCCCCCCCC		22333914
596	Phosphorylation	MLAGDGMSQVTKTLL HHCCCCHHHHHHHHH		-
599	Phosphorylation	GDGMSQVTKTLLDLT CCCHHHHHHHHHHHH		-
619	Phosphorylation	YAGDLLMSVEILRNV CHHHHHHHHHHHHHC		18669648
625	N-linked_Glycosylation	MSVEILRNVTDTFKR HHHHHHHHCCHHHHH		22333914
744	Phosphorylation	DRVVIPKSIFTPVSS CCEEEEHHHCCCCCC		25907765
747	Phosphorylation	VIPKSIFTPVSSKEL EEEHHHCCCCCCCCC		27732954
750	Phosphorylation	KSIFTPVSSKELDES HHHCCCCCCCCCCCC		27732954
751	Phosphorylation	SIFTPVSSKELDESS HHCCCCCCCCCCCCH		27732954
767	Phosphorylation	FVLGAVLYKNLDLIL HHHHHHHHHCHHCHH		-
779	N-linked_Glycosylation	LILPTLRNYTVINSK CHHHHHCCCEEECCE		UniProtKB CARBOHYD
780	Phosphorylation	ILPTLRNYTVINSKI HHHHHCCCEEECCEE		22210691
781	Phosphorylation	LPTLRNYTVINSKII HHHHCCCEEECCEEE		22210691
785	Phosphorylation	RNYTVINSKIIVVTI CCCEEECCEEEEEEE		22210691
812	N-linked_Glycosylation	IELAHLANGTLNPYC HHHHHHHCCCCCCCE		UniProtKB CARBOHYD
827	Phosphorylation	VLWDDSKTNESLGTW EEECCCCCCCCCCCC		-
828	N-linked_Glycosylation	LWDDSKTNESLGTWS EECCCCCCCCCCCCC		UniProtKB CARBOHYD
830	Phosphorylation	DDSKTNESLGTWSTQ CCCCCCCCCCCCCCC		-
835	Phosphorylation	NESLGTWSTQGCKTV CCCCCCCCCCCCCEE		25332170
836	Phosphorylation	ESLGTWSTQGCKTVL CCCCCCCCCCCCEEE		-
937	N-linked_Glycosylation	VGQTQTHNKSICTTT ECCCCCCCCCCCHHH		UniProtKB CARBOHYD
1056	Ubiquitination	SRDGILDKKLKHRAG CCCCCCCHHHHHCCC		32015554
1213	Phosphorylation	PCRAATITGTLSRIS CCCCCEEEEEEEEEE		26437602
1215	Phosphorylation	RAATITGTLSRISLN CCCEEEEEEEEEECC		26437602
1220	Phosphorylation	TGTLSRISLNDDEEE EEEEEEEECCCCCCC		27732954
1230	Phosphorylation	DDEEEKGTNPEGLSY CCCCCCCCCCCCCCC		27732954
1237	Phosphorylation	TNPEGLSYSTLPGNV CCCCCCCCCCCCCCE		25884760
1239	Phosphorylation	PEGLSYSTLPGNVIS CCCCCCCCCCCCEEE		25884760
1282	Phosphorylation	SELRRTVYLCTDDNL CHHHHEEEEECCCCC		25884760
1285	Phosphorylation	RRTVYLCTDDNLRGA HHEEEEECCCCCCCC		22210691
1306	Phosphorylation	PQERMMESDYIVMPR HHHHHCCCCEEECCH		22210691
1308	Phosphorylation	ERMMESDYIVMPRSS HHHCCCCEEECCHHH		25884760
1401	Phosphorylation	DNAGLSRSETGSTIS CCCCCCCCCCCCCCC		27732954
1403	Phosphorylation	AGLSRSETGSTISMS CCCCCCCCCCCCCHH		27732954
1405	Phosphorylation	LSRSETGSTISMSSL CCCCCCCCCCCHHHH		27732954
1406	Phosphorylation	SRSETGSTISMSSLE CCCCCCCCCCHHHHH		27732954
1408	Phosphorylation	SETGSTISMSSLERR CCCCCCCCHHHHHHH		27732954
1410	Phosphorylation	TGSTISMSSLERRKS CCCCCCHHHHHHHHH		27732954
1411	Phosphorylation	GSTISMSSLERRKSR CCCCCHHHHHHHHHH		27732954
1417	Phosphorylation	SSLERRKSRYSDLDF HHHHHHHHHCCCCCH		20058876
1419	Phosphorylation	LERRKSRYSDLDFEK HHHHHHHCCCCCHHH		25884760
1420	Phosphorylation	ERRKSRYSDLDFEKV HHHHHHCCCCCHHHH		-
1457	Phosphorylation	RFRDIPNTSSMENPA HHCCCCCCCCCCCCC		25311616
1479	Phosphorylation	TFKNPSEYPHYTTIN CCCCHHHCCCCEEEE		25884760
1482	Phosphorylation	NPSEYPHYTTINVLD CHHHCCCCEEEEEEC		25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPT11_HUMAN	GPATCH11	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.