AGO2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGO2_ARATH
• UniProt AC: Q9SHF3
• Protein Name: Protein argonaute 2
• Gene Name: AGO2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1014
• Protein Description: Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates mainly with siRNAs of 21 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine. Probably involved in antiviral RNA silencing. Associates with siRNA derived from cucumber mosaic virus (CMV). Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO2 function in RNA silencing. Required to direct NERD-dependent DNA methylation and silencing..
• Protein Sequence: MERGGYRGGRGDGRGRGGRGYGGGGGGGEQGRDRGYGGGEQGRGRGSERGGGNRGQGRGEQQDFRSQSQRGPPPGHGGRGTTQFQQPRPQVAPQPSQAPASYAGSVGGVAGRGAWGRKPQVPSDSASPSTSTTVVSEPVRVAEVMNLKPSVQVATSDRKEPMKRPDRGGVVAVRRVNLYVNHYKVNFNPESVIRHYDVEIKGEIPTKKVSRFELAMVRDKVFTDNPDEFPLAMTAYDGQKNIFSAVELPTGSYKVEYPKTEEMRGRSYTFTIKQVNVLKLGDLKEYMTGRSSFNPRDVLQGMDVVMKEHPSKCMITVGKSFFTRETEPDEDFRFGVIAAKGYRHTLKPTAQGLSLCLDYSVLAFRKAMSVIEYLKLYFNWSDMRQFRRRDVEEELIGLKVTVNHRKNKQKLTIVGLSMQNTKDIKFDLIDQEGNEPPRKTSIVEYFRIKYGRHIVHKDIPCLDLGKNGRQNFVPMEFCDLVEGQIYPKDNLDKDSALWLKKLSLVNPQQRQRNIDKMIKARNGPSGGEIIGNFGLKVDTNMTPVEGRVLKAPSLKLAERGRVVREEPNPRQNNQWNLMKKGVTRGSIVKHWAVLDFTASERFNKMPNDFVDNLIDRCWRLGMQMEAPIVYKTSRMETLSNGNAIEELLRSVIDEASRKHGGARPTLVLCAMSRKDDGYKTLKWIAETKLGLVTQCFLTGPATKGGDQYRANLALKMNAKVGGSNVELMDTFSFFKKEDEVMFIGADVNHPAARDKMSPSIVAVVGTLNWPEANRYAARVIAQPHRKEEIQGFGDACLELVKAHVQATGKRPNKIVIFRDGVSDAQFDMVLNVELLDVKLTFEKNGYNPKITVIVAQKRHQTRFFPATNNDGSDKGNVPSGTVVDTKVIHPYEYDFYLCSHHGGIGTSKPTHYYTLWDELGFTSDQVQKLIFEMCFTFTRCTKPVSLVPPVYYADMVAFRGRMYHEASSREKNFKQPRGASTSAASLASSLSSLTIEDKAIFKLHAELENVMFFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
196	Phosphorylation	PESVIRHYDVEIKGE HHHHHEEEEEEECCC	16.31	22074104
206	Phosphorylation	EIKGEIPTKKVSRFE EECCCCCCCEECCCE	49.51	22074104
267	Phosphorylation	TEEMRGRSYTFTIKQ CHHHCCCEEEEEEEE	31.20	23820729
268	Phosphorylation	EEMRGRSYTFTIKQV HHHCCCEEEEEEEEE	12.43	23820729
269	Phosphorylation	EMRGRSYTFTIKQVN HHCCCEEEEEEEEEE	18.62	23820729
271	Phosphorylation	RGRSYTFTIKQVNVL CCCEEEEEEEEEEEE	21.33	23820729
637	Phosphorylation	YKTSRMETLSNGNAI EECCCCEECCCCHHH	26.58	23776212
639	Phosphorylation	TSRMETLSNGNAIEE CCCCEECCCCHHHHH	50.54	23776212
650	Phosphorylation	AIEELLRSVIDEASR HHHHHHHHHHHHHHH	24.32	23776212
656	Phosphorylation	RSVIDEASRKHGGAR HHHHHHHHHHCCCCC	39.55	23776212
991	Phosphorylation	ASLASSLSSLTIEDK HHHHHHHHCCCCCCH	25.83	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGO2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGO2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGO2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.