AGD8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGD8_ARATH
• UniProt AC: Q8H100
• Protein Name: Probable ADP-ribosylation factor GTPase-activating protein AGD8
• Gene Name: AGD8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 413
• Protein Description: GTPase-activating protein (GAP) for ADP ribosylation factor (ARF)..
• Protein Sequence: MASSSADNLTDKNIVFRKLKSKSENKVCFDCSAKNPTWASVTYGIFLCIDCSATHRNLGVHISFVRSTNLDSWSPEQLRTMMFGGNNRAQVFFKQHGWTDGGKIEAKYTSRAADLYRQILAKEVAKAIAEETNSGLLSSPVATSQLPEVSNGVSSYSVKEELPLSKHEATSATSSPKASNTVVPSTFKKPIGAKRTGKTGGLGARKLTTKPKDNLYEQKPEEVAPVIPAVSSTNNGESKSSAGSSFASRFEYNDDLQSGGQSVGGTQVLNHVAPPKSSSFFSDFGMDSSFPKKSSSNSSKSQVEESDEARKKFTNAKSISSAQYFGDQNKNADLESKATLQKFAGSASISSADFYGHDQDDSNIDITASDLINRLSFQAQQDLSSLVNIAGETKKKLGTLASGIFSDIQDRML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSSADNL ------CCCCCCCCC	20.37	22223895
3	Phosphorylation	-----MASSSADNLT -----CCCCCCCCCC	24.43	25561503
4	Phosphorylation	----MASSSADNLTD ----CCCCCCCCCCC	21.73	25561503
5	Phosphorylation	---MASSSADNLTDK ---CCCCCCCCCCCC	36.83	25561503
138	Phosphorylation	ETNSGLLSSPVATSQ HCCCCCCCCCCCHHC	37.32	22631563
139	Phosphorylation	TNSGLLSSPVATSQL CCCCCCCCCCCHHCC	24.30	22631563
170	Phosphorylation	PLSKHEATSATSSPK CCCHHCCCCCCCCCC	18.86	23776212
171	Phosphorylation	LSKHEATSATSSPKA CCHHCCCCCCCCCCC	36.28	23776212
173	Phosphorylation	KHEATSATSSPKASN HHCCCCCCCCCCCCC	29.51	23776212
174	Phosphorylation	HEATSATSSPKASNT HCCCCCCCCCCCCCC	44.34	23776212
175	Phosphorylation	EATSATSSPKASNTV CCCCCCCCCCCCCCC	26.51	23776212
240	Phosphorylation	TNNGESKSSAGSSFA CCCCCCCCCCCCCCH	34.40	25561503
301	Phosphorylation	SSSNSSKSQVEESDE CCCCCCHHHHHHCHH	41.21	30407730
306	Phosphorylation	SKSQVEESDEARKKF CHHHHHHCHHHHHHH	27.52	30407730
318	Phosphorylation	KKFTNAKSISSAQYF HHHCCCCHHHHHHHH	25.87	19880383
320	Phosphorylation	FTNAKSISSAQYFGD HCCCCHHHHHHHHCC	27.06	23776212
321	Phosphorylation	TNAKSISSAQYFGDQ CCCCHHHHHHHHCCC	20.09	23776212
324	Phosphorylation	KSISSAQYFGDQNKN CHHHHHHHHCCCCCC	14.83	23776212
399	Phosphorylation	ETKKKLGTLASGIFS HHHHHHHHHHHHHHH	29.59	23172892
402	Phosphorylation	KKLGTLASGIFSDIQ HHHHHHHHHHHHHHH	35.22	30291188
406	Phosphorylation	TLASGIFSDIQDRML HHHHHHHHHHHHHCC	31.70	23172892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGD8_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGD8_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGD8_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of AGD8_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175 AND SER-318, ANDMASS SPECTROMETRY.
PubMed: 19376835