dbPTM

AGD5_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AGD5_ARATH
UniProt AC	Q9FL69
Protein Name	Probable ADP-ribosylation factor GTPase-activating protein AGD5
Gene Name	AGD5
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	483
Subcellular Localization
Protein Description	GTPase-activating protein (GAP) for ADP ribosylation factor (ARF)..
Protein Sequence	MNEKANVSKELNARHRKILEGLLKHPENRECADCKTKGPRWASVNLGIFICMQCSGIHRSLGVHISKVRSATLDTWLPEQVAFIQSMGNDKANSYWEAELPPNYDRVGIENFIRAKYEEKRWVSRGEKARSPPRVEQERRKSVERSGPGYEHGHSSSPVNLFEERKTIPASRTRNNVAATRINLPVPPQGPSQVIKPQQKMESAATPVEREKQAVNVAPASDPPKVDFATDLFNMLSMDDSTTNTSEATPGDTPADDNSWAGFQSAGSGQTAEKIVTAKPAESSSPPASSSDFEDLFKDTPNLTTQQAPKDVKGDIMSLFEKTNIVSPFAMHQQQVAMLAQQQALYMAAAKAAGGTPNGVNQQAIANALNVASANWSNPGGYQIPGMTNPVGGQADLQKLMQNMNMNANMNTRPAQPQENTLQYPSSSFYTMGQANQVNGMTPNSTGKPQSSSATQPTSTTPSSQSGKDFDFSSLMDGMFTKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
131	Phosphorylation	SRGEKARSPPRVEQE CCCCCCCCCCHHHHH	44.08	23776212
142	Phosphorylation	VEQERRKSVERSGPG HHHHHHHHHHHHCCC	27.65	23776212
155	Phosphorylation	PGYEHGHSSSPVNLF CCCCCCCCCCCCCHH	36.78	23776212
156	Phosphorylation	GYEHGHSSSPVNLFE CCCCCCCCCCCCHHH	32.74	23776212
157	Phosphorylation	YEHGHSSSPVNLFEE CCCCCCCCCCCHHHH	35.56	23776212
201	Sulfoxidation	VIKPQQKMESAATPV CCCHHHHHHHCCCCC	4.23	25693801
206	Phosphorylation	QKMESAATPVEREKQ HHHHHCCCCCHHHHH	27.81	23328941
277	Phosphorylation	QTAEKIVTAKPAESS CCCEEEEECCCCCCC	32.22	19376835
283	Phosphorylation	VTAKPAESSSPPASS EECCCCCCCCCCCCC	37.92	19376835
284	Phosphorylation	TAKPAESSSPPASSS ECCCCCCCCCCCCCH	38.07	23111157
285	Phosphorylation	AKPAESSSPPASSSD CCCCCCCCCCCCCHH	44.15	19376835
289	Phosphorylation	ESSSPPASSSDFEDL CCCCCCCCCHHHHHH	35.83	19376835
290	Phosphorylation	SSSPPASSSDFEDLF CCCCCCCCHHHHHHH	35.71	19376835
291	Phosphorylation	SSPPASSSDFEDLFK CCCCCCCHHHHHHHC	43.77	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AGD5_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AGD5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AGD5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CLAH1_ARATH	AT3G11130	physical	23771894

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AGD5_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis."; de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.; J. Proteome Res. 7:2458-2470(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, AND MASSSPECTROMETRY.	18433157 [Abstract]