AFF4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AFF4_MOUSE
• UniProt AC: Q9ESC8
• Protein Name: AF4/FMR2 family member 4
• Gene Name: Aff4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1160
• Subcellular Localization: Nucleus . Associates to transcriptionally active chromatin but not at snRNA genes.
• Protein Description: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity)..
• Protein Sequence: MNREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKDYIGDRSIPKLVAIPKPAVPTTTDEKANPNFFEQRHGGSHQSSKWTPVGPAPSTSQSQKRSSALQSGHSSQRSGAGGSGASSSGQRHDRDSYSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLSSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRGPFSSGQHSSQSFPPSLMSKSSSMLQKPTAYVRPMDGQESVEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSRPLDASVSGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGPGEQKRYSTAKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQAYKKEGREQGTASNYTDPGGTKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKPEKSAAEEPRGGLKIESETPVDMAASMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSASKPSQKSREIIETDTSSSDSDGSESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHSREVQKQASEKASNKGKRKHKNDDDTRASESKKPKTEDKNSSGHKPSSSRESSKQSSTKEKDLLPSPAGPILSKDSKTEHGSRKRTVSQSSSLKSSGTSSKENSGSSSKSSSSSTAKQKKTEGKGPSSSKEAKEKAPNSSSNCPPSTPTSESSKPRRTKLAFDDRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSDTVELIKYTMKLKNYLAPDATAADKRLTVLCLRCQSLLYLRLFKLKKENALKYSKTLTEHLKNSYSNSQAPSPGLGSKAVGMPSPVSPKLSPGNSGSYSSGGSSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLARYTRQGLHWLRQDAKLIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	GEDAFPPSSPLFAEP CCCCCCCCCCCCCCC	44.84	25777480
32	Phosphorylation	EDAFPPSSPLFAEPY CCCCCCCCCCCCCCE	31.25	25777480
39	Phosphorylation	SPLFAEPYKVTSKED CCCCCCCEECCCHHH	15.03	25777480
54	Phosphorylation	KLSSRIQSMLGNYDE HHHHHHHHHHCCHHH	17.38	25168779
59	Phosphorylation	IQSMLGNYDEMKDYI HHHHHCCHHHHHHHH	16.10	25168779
63	Ubiquitination	LGNYDEMKDYIGDRS HCCHHHHHHHHCCCC	45.38	22790023
120	Phosphorylation	PAPSTSQSQKRSSAL CCCCCCHHHHHHHHH	37.12	-
156	Phosphorylation	RHDRDSYSSSRKKGQ CCCCCCCCCCCCCCC	26.28	27841257
171	Phosphorylation	HGSEHSKSRSSSPGK CCCCCCCCCCCCCCC	40.17	26643407
173	Phosphorylation	SEHSKSRSSSPGKPQ CCCCCCCCCCCCCCC	42.11	27742792
174	Phosphorylation	EHSKSRSSSPGKPQA CCCCCCCCCCCCCCH	39.17	27742792
175	Phosphorylation	HSKSRSSSPGKPQAV CCCCCCCCCCCCCHH	38.63	27742792
183	Phosphorylation	PGKPQAVSSLSSSHS CCCCCHHHHCCCCCC	28.69	25619855
184	Phosphorylation	GKPQAVSSLSSSHSR CCCCHHHHCCCCCCC	26.18	25619855
186	Phosphorylation	PQAVSSLSSSHSRSH CCHHHHCCCCCCCCC	31.57	25619855
187	Phosphorylation	QAVSSLSSSHSRSHG CHHHHCCCCCCCCCC	37.05	25619855
188	Phosphorylation	AVSSLSSSHSRSHGN HHHHCCCCCCCCCCC	23.31	25619855
190	Phosphorylation	SSLSSSHSRSHGNDH HHCCCCCCCCCCCCC	37.11	25619855
205	Phosphorylation	HSKEHQRSKSPRDPD CCHHHHHCCCCCCCC	30.80	25159016
207	Phosphorylation	KEHQRSKSPRDPDAN HHHHHCCCCCCCCCC	26.81	25159016
217	Phosphorylation	DPDANWDSPSRGPFS CCCCCCCCCCCCCCC	19.18	25159016
219	Phosphorylation	DANWDSPSRGPFSSG CCCCCCCCCCCCCCC	54.55	25159016
247	Ubiquitination	KSSSMLQKPTAYVRP CCHHHHCCCCEEECC	40.13	22790023
283	Ubiquitination	GNSMTELKPSSKAHL CCCCCCCCCCCCCCC	36.30	22790023
327	Phosphorylation	HSWPPPLTAIHTPCK HCCCCCCEEEECCCC	29.37	25338131
331	Phosphorylation	PPLTAIHTPCKTEPS CCCEEEECCCCCCCC	25.03	25338131
335	Phosphorylation	AIHTPCKTEPSKFPF EEECCCCCCCCCCCC	60.90	-
339	Ubiquitination	PCKTEPSKFPFPTKE CCCCCCCCCCCCCHH	68.70	22790023
345	Ubiquitination	SKFPFPTKESQQSNF CCCCCCCHHHCCCCC	56.45	22790023
360	Phosphorylation	GPGEQKRYSTAKTSN CCCCCHHHCCCCCCC	19.87	29895711
362	Phosphorylation	GEQKRYSTAKTSNGH CCCHHHCCCCCCCCC	24.20	29895711
365	Phosphorylation	KRYSTAKTSNGHQSK HHHCCCCCCCCCCCH	25.59	29895711
382	Phosphorylation	LKDDLKLSSSEDSDG HHHHHHCCCCCCCCC	30.17	21743459
383	Phosphorylation	KDDLKLSSSEDSDGE HHHHHCCCCCCCCCC	48.46	21743459
384	Phosphorylation	DDLKLSSSEDSDGEQ HHHHCCCCCCCCCCC	41.89	21743459
387	Phosphorylation	KLSSSEDSDGEQDCD HCCCCCCCCCCCCCC	43.39	21743459
482	Phosphorylation	KVNPHKVSPASSVDS HCCCCCCCCCHHCCC	21.39	23684622
485	Phosphorylation	PHKVSPASSVDSNIP CCCCCCCHHCCCCCC	33.99	23684622
486	Phosphorylation	HKVSPASSVDSNIPS CCCCCCHHCCCCCCH	31.86	23684622
489	Phosphorylation	SPASSVDSNIPSSQA CCCHHCCCCCCHHHH	34.21	25159016
493	Phosphorylation	SVDSNIPSSQAYKKE HCCCCCCHHHHHHHH	31.14	25159016
494	Phosphorylation	VDSNIPSSQAYKKEG CCCCCCHHHHHHHHC	17.30	25159016
497	Phosphorylation	NIPSSQAYKKEGREQ CCCHHHHHHHHCCCC	18.24	25159016
519	Phosphorylation	DPGGTKETSSATPGR CCCCCCCCCCCCCCC	29.54	29550500
520	Phosphorylation	PGGTKETSSATPGRD CCCCCCCCCCCCCCC	21.04	29550500
521	Phosphorylation	GGTKETSSATPGRDS CCCCCCCCCCCCCCC	43.51	29550500
523	Phosphorylation	TKETSSATPGRDSKT CCCCCCCCCCCCCCC	28.37	29550500
537	Phosphorylation	TIQKGSESGRGRQKS CCCCCCCCCCCCCCC	35.17	-
544	Phosphorylation	SGRGRQKSPAQSDST CCCCCCCCCCCCCCC	19.68	27087446
548	Phosphorylation	RQKSPAQSDSTTQRR CCCCCCCCCCCHHHH	35.32	23684622
550	Phosphorylation	KSPAQSDSTTQRRTV CCCCCCCCCHHHHCC	38.30	23567750
551	Phosphorylation	SPAQSDSTTQRRTVG CCCCCCCCHHHHCCC	31.75	23567750
552	Phosphorylation	PAQSDSTTQRRTVGK CCCCCCCHHHHCCCC	24.83	23567750
578	Ubiquitination	EEPRGGLKIESETPV CCCCCCCEECCCCCC	47.94	22790023
583	Phosphorylation	GLKIESETPVDMAAS CCEECCCCCCCHHHC	37.58	24759943
590	Phosphorylation	TPVDMAASMPSSRHK CCCCHHHCCCCHHHH	22.99	24759943
593	Phosphorylation	DMAASMPSSRHKAAT CHHHCCCCHHHHHHC	31.22	24759943
594	Phosphorylation	MAASMPSSRHKAATK HHHCCCCHHHHHHCC	32.31	24759943
612	Phosphorylation	KPNIKKESKSSPRPT CCCCCCCCCCCCCCC	46.87	20415495
614	Phosphorylation	NIKKESKSSPRPTAE CCCCCCCCCCCCCHH	55.65	26824392
615	Phosphorylation	IKKESKSSPRPTAEK CCCCCCCCCCCCHHH	28.76	24899341
619	Phosphorylation	SKSSPRPTAEKKKYK CCCCCCCCHHHHHHH	49.05	27681418
641	Phosphorylation	KSREIIETDTSSSDS HHHHHHCCCCCCCCC	33.88	25293948
643	Phosphorylation	REIIETDTSSSDSDG HHHHCCCCCCCCCCC	37.62	25293948
644	Phosphorylation	EIIETDTSSSDSDGS HHHCCCCCCCCCCCC	30.56	25293948
645	Phosphorylation	IIETDTSSSDSDGSE HHCCCCCCCCCCCCC	40.01	25293948
646	Phosphorylation	IETDTSSSDSDGSES HCCCCCCCCCCCCCC	40.68	25293948
648	Phosphorylation	TDTSSSDSDGSESLP CCCCCCCCCCCCCCC	45.91	25293948
651	Phosphorylation	SSSDSDGSESLPPSS CCCCCCCCCCCCCHH	29.06	25293948
653	Phosphorylation	SDSDGSESLPPSSQT CCCCCCCCCCCHHCC	48.12	25293948
663	Phosphorylation	PSSQTPKYPESNRTP CHHCCCCCCCCCCCC	17.28	25159016
666	Phosphorylation	QTPKYPESNRTPVKP CCCCCCCCCCCCCCC	27.40	25159016
669	Phosphorylation	KYPESNRTPVKPSSV CCCCCCCCCCCCCCH	36.36	23375375
674	Phosphorylation	NRTPVKPSSVEEEDS CCCCCCCCCHHHCCH	41.10	25159016
675	Phosphorylation	RTPVKPSSVEEEDSF CCCCCCCCHHHCCHH	41.92	25159016
681	Phosphorylation	SSVEEEDSFFRQRMF CCHHHCCHHHHHHHC	29.57	25159016
689	Phosphorylation	FFRQRMFSPMEEKEL HHHHHHCCCHHHHHH	17.62	26824392
698	Phosphorylation	MEEKELLSPLSEPDD HHHHHHHCCCCCCCC	36.10	24925903
701	Phosphorylation	KELLSPLSEPDDRYP HHHHCCCCCCCCCCC	50.93	24925903
707	Phosphorylation	LSEPDDRYPLIVKID CCCCCCCCCEEEEEE	14.91	18846507
769	Phosphorylation	KHKNDDDTRASESKK CCCCCCCCHHHHCCC	34.82	28576409
788	Acetylation	DKNSSGHKPSSSRES CCCCCCCCCCCCCCC	50.55	30986583
809	Phosphorylation	KEKDLLPSPAGPILS CHHHCCCCCCCCCCC	27.61	25521595
816	Phosphorylation	SPAGPILSKDSKTEH CCCCCCCCCCCCCCC	34.83	21183079
817	Acetylation	PAGPILSKDSKTEHG CCCCCCCCCCCCCCC	63.68	23806337
829	Phosphorylation	EHGSRKRTVSQSSSL CCCCCCCEECCCHHC	27.78	28833060
831	Phosphorylation	GSRKRTVSQSSSLKS CCCCCEECCCHHCCC	24.59	27087446
833	Phosphorylation	RKRTVSQSSSLKSSG CCCEECCCHHCCCCC	17.87	28833060
834	Phosphorylation	KRTVSQSSSLKSSGT CCEECCCHHCCCCCC	31.86	25521595
835	Phosphorylation	RTVSQSSSLKSSGTS CEECCCHHCCCCCCC	45.09	28833060
838	Phosphorylation	SQSSSLKSSGTSSKE CCCHHCCCCCCCCCC	39.01	27149854
839	Phosphorylation	QSSSLKSSGTSSKEN CCHHCCCCCCCCCCC	44.49	27149854
841	Phosphorylation	SSLKSSGTSSKENSG HHCCCCCCCCCCCCC	31.60	27149854
842	Phosphorylation	SLKSSGTSSKENSGS HCCCCCCCCCCCCCC	42.83	27149854
843	Phosphorylation	LKSSGTSSKENSGSS CCCCCCCCCCCCCCC	43.77	27149854
847	Phosphorylation	GTSSKENSGSSSKSS CCCCCCCCCCCCCCC	40.94	27149854
849	Phosphorylation	SSKENSGSSSKSSSS CCCCCCCCCCCCCCC	31.12	27149854
850	Phosphorylation	SKENSGSSSKSSSSS CCCCCCCCCCCCCCC	45.36	27149854
851	Phosphorylation	KENSGSSSKSSSSST CCCCCCCCCCCCCCH	37.95	27149854
853	Phosphorylation	NSGSSSKSSSSSTAK CCCCCCCCCCCCHHH	37.08	27149854
854	Phosphorylation	SGSSSKSSSSSTAKQ CCCCCCCCCCCHHHH	37.67	27149854
855	Phosphorylation	GSSSKSSSSSTAKQK CCCCCCCCCCHHHHH	35.08	27149854
856	Phosphorylation	SSSKSSSSSTAKQKK CCCCCCCCCHHHHHH	33.39	27149854
857	Phosphorylation	SSKSSSSSTAKQKKT CCCCCCCCHHHHHHC	34.04	27149854
858	Phosphorylation	SKSSSSSTAKQKKTE CCCCCCCHHHHHHCC	39.56	27149854
889	Phosphorylation	SSSNCPPSTPTSESS CCCCCCCCCCCCCCC	31.96	25619855
890	Phosphorylation	SSNCPPSTPTSESSK CCCCCCCCCCCCCCC	36.04	25619855
892	Phosphorylation	NCPPSTPTSESSKPR CCCCCCCCCCCCCCC	45.26	25619855
893	Phosphorylation	CPPSTPTSESSKPRR CCCCCCCCCCCCCCC	36.36	25619855
1032	Phosphorylation	LTEHLKNSYSNSQAP HHHHHHHHHCCCCCC	28.49	25619855
1033	Phosphorylation	TEHLKNSYSNSQAPS HHHHHHHHCCCCCCC	22.67	25619855
1034	Phosphorylation	EHLKNSYSNSQAPSP HHHHHHHCCCCCCCC	29.80	25619855
1036	Phosphorylation	LKNSYSNSQAPSPGL HHHHHCCCCCCCCCC	23.06	25619855
1040	Phosphorylation	YSNSQAPSPGLGSKA HCCCCCCCCCCCCCC	34.32	25521595
1045	Phosphorylation	APSPGLGSKAVGMPS CCCCCCCCCCCCCCC	23.60	25619855
1052	Phosphorylation	SKAVGMPSPVSPKLS CCCCCCCCCCCCCCC	29.10	23527152
1055	Phosphorylation	VGMPSPVSPKLSPGN CCCCCCCCCCCCCCC	21.50	25521595
1059	Phosphorylation	SPVSPKLSPGNSGSY CCCCCCCCCCCCCCC	36.57	21082442
1063	Phosphorylation	PKLSPGNSGSYSSGG CCCCCCCCCCCCCCC	34.72	21659605
1065	Phosphorylation	LSPGNSGSYSSGGSS CCCCCCCCCCCCCCC	22.97	28066266
1066	Phosphorylation	SPGNSGSYSSGGSSA CCCCCCCCCCCCCCC	15.47	25293948
1067	Phosphorylation	PGNSGSYSSGGSSAS CCCCCCCCCCCCCCC	24.97	25293948
1068	Phosphorylation	GNSGSYSSGGSSASA CCCCCCCCCCCCCCC	38.65	25293948
1071	Phosphorylation	GSYSSGGSSASASGS CCCCCCCCCCCCCCC	26.68	25293948
1072	Phosphorylation	SYSSGGSSASASGSS CCCCCCCCCCCCCCC	29.53	25293948
1074	Phosphorylation	SSGGSSASASGSSVT CCCCCCCCCCCCCCC	25.56	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AFF4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AFF4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AFF4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AFF4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.