AFF3_HUMAN - dbPTM
AFF3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AFF3_HUMAN
UniProt AC P51826
Protein Name AF4/FMR2 family member 3
Gene Name AFF3
Organism Homo sapiens (Human).
Sequence Length 1226
Subcellular Localization Nucleus.
Protein Description Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA..
Protein Sequence MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDSGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
145PhosphorylationVQQSKRGTMGWQKAG
ECCCCCCCCCCHHCC		19.2868735075
248PhosphorylationQDQAPDESPKLKSSS
CCCCCCCCCCCCCCC		34.4122199227
271AcetylationYRGVPASKPEPARAK
CCCCCCCCCCCHHHH		56.3525953088
273PhosphorylationGVPASKPEPARAKAK
CCCCCCCCCHHHHHH		56.1627251275
278AcetylationKPEPARAKAKLSKFS
CCCCHHHHHHHHHCC		40.27164463
280AcetylationEPARAKAKLSKFSIP
CCHHHHHHHHHCCCC		53.22164467
285PhosphorylationKAKLSKFSIPKQGEE
HHHHHHCCCCCCCCC		41.5424719451
310PhosphorylationEEIIREMTWLPPLSA
HHHHHHHCCCCCHHH		21.0618669648
316PhosphorylationMTWLPPLSAIQAPGK
HCCCCCHHHCCCCCC		29.1518669648
336PhosphorylationFPFPNKDSQLVSSGH
CCCCCCCCCCCCCCC		27.3329083192
340PhosphorylationNKDSQLVSSGHNNPK
CCCCCCCCCCCCCCC		38.9129083192
341PhosphorylationKDSQLVSSGHNNPKK
CCCCCCCCCCCCCCC		36.2718669648
393PhosphorylationRTALRALSDSAVVQQ
HHHHHHHHHCCEECC		28.6514891069
395PhosphorylationALRALSDSAVVQQPN
HHHHHHHCCEECCCC		21.4228450419
406PhosphorylationQQPNCRTSVPSSKGS
CCCCCCCCCCCCCCC		16.8126657352
409PhosphorylationNCRTSVPSSKGSSSS
CCCCCCCCCCCCCCC		42.3927251275
414PhosphorylationVPSSKGSSSSSSSGS
CCCCCCCCCCCCCCC		42.8010405697
418PhosphorylationKGSSSSSSSGSSSSS
CCCCCCCCCCCCCCC		40.4424719451
431PhosphorylationSSSDSESSSGSDSET
CCCCCCCCCCCCCCC		34.3727251275
434PhosphorylationDSESSSGSDSETESS
CCCCCCCCCCCCCCC		39.6527251275
436PhosphorylationESSSGSDSETESSSS
CCCCCCCCCCCCCCC		48.3810405707
440PhosphorylationGSDSETESSSSESEG
CCCCCCCCCCCCCCC		42.8310405717
524AcetylationSLREKEIKSTCKEEQ
HHCHHHHHHHCCHHH		40.587665143
535PhosphorylationKEEQRPRTANKAPGS
CHHHCCCCCCCCCCC		36.9546160169
538AcetylationQRPRTANKAPGSKGV
HCCCCCCCCCCCCCC		54.1925953088
542PhosphorylationTANKAPGSKGVKQKS
CCCCCCCCCCCCCCC		25.7746160151
543AcetylationANKAPGSKGVKQKSP
CCCCCCCCCCCCCCC		73.8925953088
549PhosphorylationSKGVKQKSPPAAVAV
CCCCCCCCCCHHHHH		33.3582900377
559PhosphorylationAAVAVAVSAAAPPPA
HHHHHHHHCCCCCCC		11.4928122231
574PhosphorylationVPCAPAENAPAPARR
CCCCCCCCCCCCHHH		54.0224719451
626AcetylationVVPPEPTKTRPCGNN
ECCCCCCCCCCCCCC		53.9322361491
643PhosphorylationSHRKELRSSVTCEKR
HHHHHHHHHCCHHHH		41.6124702127
644PhosphorylationHRKELRSSVTCEKRR
HHHHHHHHCCHHHHH		18.2724702127
646PhosphorylationKELRSSVTCEKRRTR
HHHHHHCCHHHHHHC		19.5224702127
673PhosphorylationIETESSSSSSSSDSD
HCCCCCCCCCCCCCH		35.8730576142
676PhosphorylationESSSSSSSSDSDLES
CCCCCCCCCCCHHHH		39.8630576142
679PhosphorylationSSSSSSDSDLESEQE
CCCCCCCCHHHHHHH		46.1546160157
683PhosphorylationSSDSDLESEQEEYPL
CCCCHHHHHHHHCCC		52.4530576142
730O-linked_GlycosylationVGSINARTTSDIAKE
CCCCCCCCHHHHHHH		28.3930379171
755PhosphorylationFGRNELLSPLKDSDE
CCCCCCCCCCCCHHH		40.5919369195
773PhosphorylationLWVKIDLTLLSRIPE
HHHHHHHHHHHCCCC		23.1646160175
780PhosphorylationTLLSRIPEHLPQEPG
HHHHCCCCCCCCCCC		56.5424719451
806PhosphorylationSAPPSHTSDTPAEKA
CCCCCCCCCCHHHHH		33.7828348404
808PhosphorylationPPSHTSDTPAEKALP
CCCCCCCCHHHHHCC		24.9428348404
847PhosphorylationDSSSRLATSTSNTLS
CCCCCCCCCCCCCCC		36.8150563859
852PhosphorylationLATSTSNTLSANHCN
CCCCCCCCCCCCCCC		23.1268737265
854PhosphorylationTSTSNTLSANHCNMN
CCCCCCCCCCCCCCC		25.6168737271
864PhosphorylationHCNMNINSVAIPINK
CCCCCCCEEEEECCC		14.7750563865
878PhosphorylationKNEKMLRSPISPLSD
CCCHHHCCCCCCCCH		23.7130266825
881PhosphorylationKMLRSPISPLSDASK
HHHCCCCCCCCHHHC		24.1530266825
884PhosphorylationRSPISPLSDASKHKY
CCCCCCCCHHHCCCC		34.2230266825
887PhosphorylationISPLSDASKHKYTSE
CCCCCHHHCCCCCCC		40.0428450419
903PhosphorylationLTSSSRPNGNSLFTS
CCCCCCCCCCCCCCC		62.2624719451
906PhosphorylationSSRPNGNSLFTSASS
CCCCCCCCCCCCCCC		26.6824719451
921PhosphorylationSKKPKADSQLQPHGG
CCCCCCCCCCCCCCH		37.3424719451
931PhosphorylationQPHGGDLTKAAHNNS
CCCCHHHHHHHHCCC		24.3124719451
938PhosphorylationTKAAHNNSENIPLHK
HHHHHCCCCCCCCCC		37.02113310201
946PhosphorylationENIPLHKSRPQTKPW
CCCCCCCCCCCCCCC		38.1424719451
950PhosphorylationLHKSRPQTKPWSPGS
CCCCCCCCCCCCCCC		41.5846160181
954PhosphorylationRPQTKPWSPGSNGHR
CCCCCCCCCCCCCCC		28.1046160163
956PhosphorylationQTKPWSPGSNGHRDC
CCCCCCCCCCCCCCC		28.3824719451
957PhosphorylationTKPWSPGSNGHRDCK
CCCCCCCCCCCCCCC		42.9282900383
967UbiquitinationHRDCKRQKLVFDDMP
CCCCCCCCEEECCCC		51.13-
979PhosphorylationDMPRSADYFMQEAKR
CCCHHHHHHHHHHHH		10.7324719451
985UbiquitinationDYFMQEAKRMKHKAD
HHHHHHHHHHHHHHH		52.88-
1093PhosphorylationYSKALIDYFKNSSKA
HHHHHHHHHHCCCCC		14.9528270605
1097PhosphorylationLIDYFKNSSKAAQAP
HHHHHHCCCCCCCCC		33.5328270605
1098PhosphorylationIDYFKNSSKAAQAPS
HHHHHCCCCCCCCCC		35.3928270605
1105PhosphorylationSKAAQAPSPWGASGK
CCCCCCCCCCCCCCC		35.9828450419
1121PhosphorylationTGTPSPMSPNPSPAS
CCCCCCCCCCCCCCC		25.5527251275
1125PhosphorylationSPMSPNPSPASSVGS
CCCCCCCCCCCCCCC		39.4728348404
1129PhosphorylationPNPSPASSVGSQGSL
CCCCCCCCCCCCCCC		32.3846160145
1130PhosphorylationNPSPASSVGSQGSLS
CCCCCCCCCCCCCCC		8.7224719451
1146PhosphorylationASALSPSTIVSIPQR
CCCCCHHHHCCHHHH		28.8727251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AFF3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AFF3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AFF3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AFF3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AFF3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-881, AND MASSSPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393; SER-755 ANDSER-881, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-881, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-310 AND SER-316, ANDMASS SPECTROMETRY.

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