AF1L1_HUMAN - dbPTM
AF1L1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AF1L1_HUMAN
UniProt AC Q8TED9
Protein Name Actin filament-associated protein 1-like 1
Gene Name AFAP1L1
Organism Homo sapiens (Human).
Sequence Length 768
Subcellular Localization Cytoplasm . Cell projection, podosome . Cell projection, invadopodium . In the cytosol, associated with actin stress fibers.
Protein Description May be involved in podosome and invadosome formation..
Protein Sequence MDRGQVLEQLLPELTGLLSLLDHEYLSDTTLEKKMAVASILQSLQPLPAKEVSYLYVNTADLHSGPSFVESLFEEFDCDLSDLRDMPEDDGEPSKGASPELAKSPRLRNAADLPPPLPNKPPPEDYYEEALPLGPGKSPEYISSHNGCSPSHSIVDGYYEDADSSYPATRVNGELKSSYNDSDAMSSSYESYDEEEEEGKSPQPRHQWPSEEASMHLVRECRICAFLLRKKRFGQWAKQLTVIREDQLLCYKSSKDRQPHLRLALDTCSIIYVPKDSRHKRHELRFTQGATEVLVLALQSREQAEEWLKVIREVSKPVGGAEGVEVPRSPVLLCKLDLDKRLSQEKQTSDSDSVGVGDNCSTLGRRETCDHGKGKKSSLAELKGSMSRAAGRKITRIIGFSKKKTLADDLQTSSTEEEVPCCGYLNVLVNQGWKERWCRLKCNTLYFHKDHMDLRTHVNAIALQGCEVAPGFGPRHPFAFRILRNRQEVAILEASCSEDMGRWLGLLLVEMGSRVTPEALHYDYVDVETLTSIVSAGRNSFLYARSCQNQWPEPRVYDDVPYEKMQDEEPERPTGAQVKRHASSCSEKSHRVDPQVKVKRHASSANQYKYGKNRAEEDARRYLVEKEKLEKEKETIRTELIALRQEKRELKEAIRSSPGAKLKALEEAVATLEAQCRAKEERRIDLELKLVAVKERLQQSLAGGPALGLSVSSKPKSGETANKPQNSVPEQPLPVNCVSELRKRSPSIVASNQGRVLQKAKEWEMKKT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43PhosphorylationAVASILQSLQPLPAK
HHHHHHHHCCCCCHH		26.0646160061
81PhosphorylationEEFDCDLSDLRDMPE
HHCCCCHHHHCCCCC		22.7324719451
94PhosphorylationPEDDGEPSKGASPEL
CCCCCCCCCCCCHHH		39.1426657352
98PhosphorylationGEPSKGASPELAKSP
CCCCCCCCHHHHHCC		27.8129255136
104PhosphorylationASPELAKSPRLRNAA
CCHHHHHCCCCCCCC		15.0529139019
126PhosphorylationNKPPPEDYYEEALPL
CCCCCHHHHHHCCCC		15.8921945579
127PhosphorylationKPPPEDYYEEALPLG
CCCCHHHHHHCCCCC		21.4421945579
138PhosphorylationLPLGPGKSPEYISSH
CCCCCCCCHHHHHCC		28.9527642862
143PhosphorylationGKSPEYISSHNGCSP
CCCHHHHHCCCCCCC		25.3328348404
144PhosphorylationKSPEYISSHNGCSPS
CCHHHHHCCCCCCCC		16.0628348404
149PhosphorylationISSHNGCSPSHSIVD
HHCCCCCCCCCCCCC		30.7327642862
151PhosphorylationSHNGCSPSHSIVDGY
CCCCCCCCCCCCCCC		17.3627642862
153PhosphorylationNGCSPSHSIVDGYYE
CCCCCCCCCCCCCCC		28.7528348404
158PhosphorylationSHSIVDGYYEDADSS
CCCCCCCCCCCCCCC		10.147161325
159PhosphorylationHSIVDGYYEDADSSY
CCCCCCCCCCCCCCC		16.9224248375
164PhosphorylationGYYEDADSSYPATRV
CCCCCCCCCCCCEEE		33.2327642862
165PhosphorylationYYEDADSSYPATRVN
CCCCCCCCCCCEEEC		35.3724248375
166PhosphorylationYEDADSSYPATRVNG
CCCCCCCCCCEEECC		10.8027642862
186PhosphorylationYNDSDAMSSSYESYD
CCCHHHHHHHCCCCC		20.1827251275
187PhosphorylationNDSDAMSSSYESYDE
CCHHHHHHHCCCCCH		24.6927251275
188PhosphorylationDSDAMSSSYESYDEE
CHHHHHHHCCCCCHH		26.1327251275
189PhosphorylationSDAMSSSYESYDEEE
HHHHHHHCCCCCHHH		15.7327251275
191PhosphorylationAMSSSYESYDEEEEE
HHHHHCCCCCHHHHC		29.6528857561
192PhosphorylationMSSSYESYDEEEEEG
HHHHCCCCCHHHHCC		18.5524114839
241PhosphorylationGQWAKQLTVIREDQL
HHHHHHHEEEECCEE		16.0523312004
315PhosphorylationLKVIREVSKPVGGAE
HHHHHHHCCCCCCCC		26.8723403867
316UbiquitinationKVIREVSKPVGGAEG
HHHHHHCCCCCCCCC		49.2329967540
329PhosphorylationEGVEVPRSPVLLCKL
CCCCCCCCCEEEEEC		17.1930266825
342 (in isoform 3)Phosphorylation-8.3623025827
343PhosphorylationLDLDKRLSQEKQTSD
CCHHHHHHHCCCCCC		40.08-
344 (in isoform 3)Phosphorylation-67.5123025827
348PhosphorylationRLSQEKQTSDSDSVG
HHHHCCCCCCCCCCC		45.6427251275
349PhosphorylationLSQEKQTSDSDSVGV
HHHCCCCCCCCCCCC		32.4028857561
351PhosphorylationQEKQTSDSDSVGVGD
HCCCCCCCCCCCCCC		31.3928857561
353PhosphorylationKQTSDSDSVGVGDNC
CCCCCCCCCCCCCCC		25.4025850435
361PhosphorylationVGVGDNCSTLGRRET
CCCCCCCCCCCCCCC		32.6825850435
362PhosphorylationGVGDNCSTLGRRETC
CCCCCCCCCCCCCCC		35.1225850435
376MethylationCDHGKGKKSSLAELK
CCCCCCCCHHHHHHH		54.68-
377PhosphorylationDHGKGKKSSLAELKG
CCCCCCCHHHHHHHH		33.7923312004
378PhosphorylationHGKGKKSSLAELKGS
CCCCCCHHHHHHHHH		40.2424719451
383MethylationKSSLAELKGSMSRAA
CHHHHHHHHHHHHHH		40.21-
385PhosphorylationSLAELKGSMSRAAGR
HHHHHHHHHHHHHHH		16.4023403867
387PhosphorylationAELKGSMSRAAGRKI
HHHHHHHHHHHHHHH		22.0623403867
395PhosphorylationRAAGRKITRIIGFSK
HHHHHHHHHHCCCCC		20.8930849941
441MethylationKERWCRLKCNTLYFH
HHHHHHCCCCEEEEC		13.19-
446PhosphorylationRLKCNTLYFHKDHMD
HCCCCEEEECCCCCH		11.127066969
513PhosphorylationLLLVEMGSRVTPEAL
HHHHHCCCCCCHHHH		23.4446160067
516PhosphorylationVEMGSRVTPEALHYD
HHCCCCCCHHHHCCC		17.8246160079
522PhosphorylationVTPEALHYDYVDVET
CCHHHHCCCCCCHHH		15.1527642862
524PhosphorylationPEALHYDYVDVETLT
HHHHCCCCCCHHHHH		7.44113328905
543PhosphorylationAGRNSFLYARSCQNQ
CCCCCEEEECCCCCC		9.6527642862
557PhosphorylationQWPEPRVYDDVPYEK
CCCCCCEECCCCHHH		14.0172273
562PhosphorylationRVYDDVPYEKMQDEE
CEECCCCHHHCCCCC		28.2027642862
570PhosphorylationEKMQDEEPERPTGAQ
HHCCCCCCCCCCCHH		40.6332645325
583PhosphorylationAQVKRHASSCSEKSH
HHHHHHHHHCCCHHC		26.2576990043
603PhosphorylationVKVKRHASSANQYKY
HHHHCCCCCCCHHHC		24.6929743597
713 (in isoform 2)Phosphorylation-51.31-
745PhosphorylationVSELRKRSPSIVASN
HHHHHHCCCHHEECC		26.4930266825
747PhosphorylationELRKRSPSIVASNQG
HHHHCCCHHEECCHH		30.8330266825
751PhosphorylationRSPSIVASNQGRVLQ
CCCHHEECCHHHHHH		20.8429255136
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AF1L1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AF1L1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AF1L1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AF1L1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AF1L1_HUMAN

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Related Literatures of Post-Translational Modification

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