ADT2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADT2_RAT
• UniProt AC: Q09073
• Protein Name: ADP/ATP translocase 2
• Gene Name: Slc25a5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 298
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity)..
• Protein Sequence: MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFKGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIFISWMIAQSVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTDAAVSF -------CCHHHHHH	7.45	-
2	Acetylation	------MTDAAVSFA ------CCHHHHHHH	34.05	-
7	Phosphorylation	-MTDAAVSFAKDFLA -CCHHHHHHHHHHHH	18.11	22673903
10	Acetylation	DAAVSFAKDFLAGGV HHHHHHHHHHHHHHH	47.18	22902405
22	Phosphorylation	GGVAAAISKTAVAPI HHHHHHHHCCCCCCH	21.16	23991683
23	Succinylation	GVAAAISKTAVAPIE HHHHHHHCCCCCCHH	34.10	26843850
23	Acetylation	GVAAAISKTAVAPIE HHHHHHHCCCCCCHH	34.10	25786129
23	N6-malonyllysine	GVAAAISKTAVAPIE HHHHHHHCCCCCCHH	34.10	-
23	Malonylation	GVAAAISKTAVAPIE HHHHHHHCCCCCCHH	34.10	-
33	Acetylation	VAPIERVKLLLQVQH CCCHHHHHHHHHHHH	39.37	2916819
42	Phosphorylation	LLQVQHASKQITADK HHHHHHHHCCCCCCH	23.98	23991683
43	Acetylation	LQVQHASKQITADKQ HHHHHHHCCCCCCHH	46.64	22902405
43	Succinylation	LQVQHASKQITADKQ HHHHHHHCCCCCCHH	46.64	-
43	Succinylation	LQVQHASKQITADKQ HHHHHHHCCCCCCHH	46.64	-
52	"N6,N6,N6-trimethyllysine"	ITADKQYKGIIDCVV CCCCHHHCCEEEEEE	40.93	-
52	Methylation	ITADKQYKGIIDCVV CCCCHHHCCEEEEEE	40.93	31213526
63	Acetylation	DCVVRIPKEQGVLSF EEEEEECHHHCCEEE	61.37	2916813
81	Phosphorylation	NLANVIRYFPTQALN CHHHHHHHCHHHHHH	11.64	30181290
84	Phosphorylation	NVIRYFPTQALNFAF HHHHHCHHHHHHHHC	19.30	22108457
92	N6-malonyllysine	QALNFAFKDKYKQIF HHHHHHCHHHCCEEE	50.29	-
92	Acetylation	QALNFAFKDKYKQIF HHHHHHCHHHCCEEE	50.29	2916809
92	Malonylation	QALNFAFKDKYKQIF HHHHHHCHHHCCEEE	50.29	-
94	Acetylation	LNFAFKDKYKQIFLG HHHHCHHHCCEEEEC	55.74	7617779
96	N6-malonyllysine	FAFKDKYKQIFLGGV HHCHHHCCEEEECCC	42.53	-
96	Acetylation	FAFKDKYKQIFLGGV HHCHHHCCEEEECCC	42.53	2916833
96	Malonylation	FAFKDKYKQIFLGGV HHCHHHCCEEEECCC	42.53	-
105	Succinylation	IFLGGVDKRTQFWRY EEECCCCCCHHHHHH	55.74	-
105	Acetylation	IFLGGVDKRTQFWRY EEECCCCCCHHHHHH	55.74	25786129
105	Succinylation	IFLGGVDKRTQFWRY EEECCCCCCHHHHHH	55.74	-
112	Phosphorylation	KRTQFWRYFAGNLAS CCHHHHHHHHHCHHC	6.59	23991683
119	Phosphorylation	YFAGNLASGGAAGAT HHHHCHHCCCCCCCC	40.71	23991683
126	Phosphorylation	SGGAAGATSLCFVYP CCCCCCCCEEEEEEE	22.70	23991683
127	Phosphorylation	GGAAGATSLCFVYPL CCCCCCCEEEEEEEC	23.70	23991683
147	Succinylation	RLAADVGKAGAEREF HHHHHHHHHHHHHHC	43.42	-
147	Methylation	RLAADVGKAGAEREF HHHHHHHHHHHHHHC	43.42	-
147	N6-malonyllysine	RLAADVGKAGAEREF HHHHHHHHHHHHHHC	43.42	-
147	Malonylation	RLAADVGKAGAEREF HHHHHHHHHHHHHHC	43.42	-
147	Acetylation	RLAADVGKAGAEREF HHHHHHHHHHHHHHC	43.42	25786129
155	Succinylation	AGAEREFKGLGDCLV HHHHHHCCCHHHHEE	48.77	26843850
155	Acetylation	AGAEREFKGLGDCLV HHHHHHCCCHHHHEE	48.77	2916841
155	Succinylation	AGAEREFKGLGDCLV HHHHHHCCCHHHHEE	48.77	-
163	Acetylation	GLGDCLVKIYKSDGI CHHHHEEEEECCCCC	27.63	22902405
166	Succinylation	DCLVKIYKSDGIKGL HHEEEEECCCCCCHH	45.61	26843850
166	Acetylation	DCLVKIYKSDGIKGL HHEEEEECCCCCCHH	45.61	22902405
191	Phosphorylation	IIIYRAAYFGIYDTA EEEEEEHHHCCHHHC	11.01	23991683
195	Phosphorylation	RAAYFGIYDTAKGML EEHHHCCHHHCCCCC	13.97	23991683
197	Phosphorylation	AYFGIYDTAKGMLPD HHHCCHHHCCCCCCC	17.19	25575281
199	Acetylation	FGIYDTAKGMLPDPK HCCHHHCCCCCCCCC	47.12	22902405
213	Phosphorylation	KNTHIFISWMIAQSV CCCEEEEHHHHHHHH	10.39	22817900
219	Phosphorylation	ISWMIAQSVTAVAGL EHHHHHHHHHHHHCC	16.65	19700791
242	Phosphorylation	RRRMMMQSGRKGTDI HHHHHHHCCCCCCCE	23.75	23991683
245	Acetylation	MMMQSGRKGTDIMYT HHHHCCCCCCCEEEE	70.46	55699605
245	Succinylation	MMMQSGRKGTDIMYT HHHHCCCCCCCEEEE	70.46	26843850
268	Succinylation	IARDEGGKAFFKGAW HHHCCCCCEEHHHHH	53.53	-
268	Acetylation	IARDEGGKAFFKGAW HHHCCCCCEEHHHHH	53.53	22902405
268	Succinylation	IARDEGGKAFFKGAW HHHCCCCCEEHHHHH	53.53	-
272	Acetylation	EGGKAFFKGAWSNVL CCCCEEHHHHHHHHH	41.06	22902405
276	Phosphorylation	AFFKGAWSNVLRGMG EEHHHHHHHHHHHCC	19.27	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADT2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
52	K	Methylation	Trimethylated by ANTKMT at Lys-52.	31213526

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADT2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ADT2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.