ADT1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADT1_RAT
• UniProt AC: Q05962
• Protein Name: ADP/ATP translocase 1
• Gene Name: Slc25a4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 298
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane..
• Protein Sequence: MGDQALSFLKDFLAGGIAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGSSQREFNGLGDCLTKIFKSDGLKGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGRKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDQALSFL ------CCHHHHHHH	35.42	-
7	Phosphorylation	-MGDQALSFLKDFLA -CCHHHHHHHHHHHH	31.39	22673903
10	Acetylation	DQALSFLKDFLAGGI HHHHHHHHHHHHHHH	44.41	25786129
22	Phosphorylation	GGIAAAVSKTAVAPI HHHHHHHCCCCCCCH	21.40	23991683
22	O-linked_Glycosylation	GGIAAAVSKTAVAPI HHHHHHHCCCCCCCH	21.40	27213235
23	Acetylation	GIAAAVSKTAVAPIE HHHHHHCCCCCCCHH	33.63	25786129
24	Phosphorylation	IAAAVSKTAVAPIER HHHHHCCCCCCCHHH	20.89	23991683
33	Acetylation	VAPIERVKLLLQVQH CCCHHHHHHHHHHHH	39.37	22902405
42	Phosphorylation	LLQVQHASKQISAEK HHHHHHHHHHCCHHH	23.98	23991683
43	Acetylation	LQVQHASKQISAEKQ HHHHHHHHHCCHHHH	53.05	22902405
52	Methylation	ISAEKQYKGIIDCVV CCHHHHHCCEEEEEE	40.93	31213526
57	Glutathionylation	QYKGIIDCVVRIPKE HHCCEEEEEEECCHH	1.83	22833525
63	Acetylation	DCVVRIPKEQGFLSF EEEEECCHHHCCHHH	61.37	22902405
69	O-linked_Glycosylation	PKEQGFLSFWRGNLA CHHHCCHHHHCCCHH	22.09	27213235
81	Phosphorylation	NLANVIRYFPTQALN CHHHHHHHCHHHHHH	11.64	30181290
84	Phosphorylation	NVIRYFPTQALNFAF HHHHHCHHHHHHHHC	19.30	22108457
92	Acetylation	QALNFAFKDKYKQIF HHHHHHCHHHCCEEE	50.29	25786129
94	Acetylation	LNFAFKDKYKQIFLG HHHHCHHHCCEEEEC	55.74	22902405
96	Acetylation	FAFKDKYKQIFLGGV HHCHHHCCEEEECCC	42.53	22902405
107	Acetylation	LGGVDRHKQFWRYFA ECCCHHHHHHHHHHH	48.35	22902405
112	Phosphorylation	RHKQFWRYFAGNLAS HHHHHHHHHHHCCCC	6.59	23991683
119	Phosphorylation	YFAGNLASGGAAGAT HHHHCCCCCCCCCCC	40.71	23991683
126	Phosphorylation	SGGAAGATSLCFVYP CCCCCCCCEEEEEEE	22.70	23991683
127	Phosphorylation	GGAAGATSLCFVYPL CCCCCCCEEEEEEEC	23.70	23991683
147	Succinylation	RLAADVGKGSSQREF HHHHCCCCCCCCHHC	56.31	-
147	Acetylation	RLAADVGKGSSQREF HHHHCCCCCCCCHHC	56.31	22902405
147	Succinylation	RLAADVGKGSSQREF HHHHCCCCCCCCHHC	56.31	-
147	Ubiquitination	RLAADVGKGSSQREF HHHHCCCCCCCCHHC	56.31	-
149	Phosphorylation	AADVGKGSSQREFNG HHCCCCCCCCHHCCC	27.12	27097102
150	O-linked_Glycosylation	ADVGKGSSQREFNGL HCCCCCCCCHHCCCH	41.76	27213235
150	Phosphorylation	ADVGKGSSQREFNGL HCCCCCCCCHHCCCH	41.76	27097102
160	S-nitrosylation	EFNGLGDCLTKIFKS HCCCHHHHHHHHHHH	5.02	16418269
160	S-nitrosocysteine	EFNGLGDCLTKIFKS HCCCHHHHHHHHHHH	5.02	-
163	Acetylation	GLGDCLTKIFKSDGL CHHHHHHHHHHHCCC	32.95	22902405
166	Acetylation	DCLTKIFKSDGLKGL HHHHHHHHHCCCCHH	51.62	22902405
167	O-linked_Glycosylation	CLTKIFKSDGLKGLY HHHHHHHHCCCCHHH	26.60	27213235
167	Phosphorylation	CLTKIFKSDGLKGLY HHHHHHHHCCCCHHH	26.60	23991683
171	Acetylation	IFKSDGLKGLYQGFS HHHHCCCCHHHCCCC	53.01	26302492
191	Phosphorylation	IIIYRAAYFGVYDTA EEEEEEHHHCCHHCC	10.40	23991683
195	Phosphorylation	RAAYFGVYDTAKGML EEHHHCCHHCCCCCC	14.14	23991683
197	Phosphorylation	AYFGVYDTAKGMLPD HHHCCHHCCCCCCCC	16.75	23991683
199	Acetylation	FGVYDTAKGMLPDPK HCCHHCCCCCCCCCC	47.12	22902405
219	Phosphorylation	VSWMIAQSVTAVAGL EEHHHHHHHHHHHHH	16.65	22817900
242	Phosphorylation	RRRMMMQSGRKGADI HHHHHHHCCCCCCCE	23.75	23991683
245	Succinylation	MMMQSGRKGADIMYT HHHHCCCCCCCEEEE	63.07	-
245	Succinylation	MMMQSGRKGADIMYT HHHHCCCCCCCEEEE	63.07	-
257	S-nitrosocysteine	MYTGTVDCWRKIAKD EEEECHHHHHHHHHH	3.09	-
257	S-nitrosylation	MYTGTVDCWRKIAKD EEEECHHHHHHHHHH	3.09	16418269
272	Succinylation	EGRKAFFKGAWSNVL HHHHHHHHHHHHHHH	41.06	26843850
272	Succinylation	EGRKAFFKGAWSNVL HHHHHHHHHHHHHHH	41.06	-
272	Acetylation	EGRKAFFKGAWSNVL HHHHHHHHHHHHHHH	41.06	25786129
276	Phosphorylation	AFFKGAWSNVLRGMG HHHHHHHHHHHHHCC	19.27	23991683

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADT1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADT1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADT1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ADT1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.