ADH4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADH4_MOUSE
• UniProt AC: Q9QYY9
• Protein Name: Alcohol dehydrogenase 4
• Gene Name: Adh4
• Organism: Mus musculus (Mouse).
• Sequence Length: 377
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in the reduction of benzoquinones..
• Protein Sequence: MGTQGKVIKCKAAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPSSTCAVFGLGCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKALGATDCLNPRELDKPVQDVITELTAGGVDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDKMTIPTVDVILGRSINGTFFGGWKSVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTILTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	KAAIAWKTGSPLCIE CEEEEECCCCCEEEE	31.99	23984901
20	Phosphorylation	AIAWKTGSPLCIEEI EEEECCCCCEEEEEE	21.67	23984901
23	S-palmitoylation	WKTGSPLCIEEIEVS ECCCCCEEEEEEEEC	4.12	28526873
30	Phosphorylation	CIEEIEVSPPKACEV EEEEEEECCCCCCEE	23.77	36250193
45	S-palmitoylation	RIQVIATCVCPTDIN EEEEEEEEECCCCCC	1.88	28526873
57	Malonylation	DINATDPKKKALFPV CCCCCCCCHHCCCCC	70.49	26073543
58	Malonylation	INATDPKKKALFPVV CCCCCCCHHCCCCCC	48.98	26073543
59	Malonylation	NATDPKKKALFPVVL CCCCCCHHCCCCCCC	57.35	26073543
98	S-palmitoylation	IPFFAPQCKRCKLCL ECCCCCCCCCCCCCC	2.67	28526873
99	Ubiquitination	PFFAPQCKRCKLCLS CCCCCCCCCCCCCCC	56.43	22790023
102	Ubiquitination	APQCKRCKLCLSPLT CCCCCCCCCCCCHHH	46.39	22790023
104	S-palmitoylation	QCKRCKLCLSPLTNL CCCCCCCCCCHHHHH	1.85	28526873
112	S-palmitoylation	LSPLTNLCGKLRNFK CCHHHHHHHHHHCCC	4.98	28526873
114	Ubiquitination	PLTNLCGKLRNFKYP HHHHHHHHHHCCCCC	43.19	22790023
114	Acetylation	PLTNLCGKLRNFKYP HHHHHHHHHHCCCCC	43.19	6566373
119	Ubiquitination	CGKLRNFKYPTIDQE HHHHHCCCCCCCCHH	54.60	22790023
238	Malonylation	GEKFPKAKALGATDC CCCCCCCHHCCCCCC	50.71	26320211
238	Ubiquitination	GEKFPKAKALGATDC CCCCCCCHHCCCCCC	50.71	-
245	S-palmitoylation	KALGATDCLNPRELD HHCCCCCCCCHHHCC	3.25	28526873
273	S-palmitoylation	GVDYSLDCAGTAQTL CCCEEEECHHHHHHH	4.57	28526873
303	Ubiquitination	VVGAKVDKMTIPTVD EEEEEECCCCCCCHH	40.71	27667366
305	Phosphorylation	GAKVDKMTIPTVDVI EEEECCCCCCCHHEE	29.55	26239621
308	Phosphorylation	VDKMTIPTVDVILGR ECCCCCCCHHEEEEC	26.03	26239621
326	Ubiquitination	GTFFGGWKSVDSVPN CCEECCCCCCCCCCC	43.82	22790023
330	Phosphorylation	GGWKSVDSVPNLVSD CCCCCCCCCCCHHHH	37.00	23984901
339	Ubiquitination	PNLVSDYKNKKFDLD CCHHHHCCCCCCCHH	68.25	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADH4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADH4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADH4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ADH4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A differential phosphoproteomic analysis of retinoic acid-treated P19cells.";
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
J. Proteome Res. 6:3174-3186(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, AND MASSSPECTROMETRY.
PubMed: 17622165