ADCY7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADCY7_HUMAN
• UniProt AC: P51828
• Protein Name: Adenylate cyclase type 7
• Gene Name: ADCY7
• Organism: Homo sapiens (Human).
• Sequence Length: 1080
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: This is a membrane-bound, calcium-inhibitable adenylyl cyclase..
• Protein Sequence: MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
154	Phosphorylation	AVAVGAVSTASHLLV CHHHHCCHHHHHHHH	20.09	46159659
155	Phosphorylation	VAVGAVSTASHLLVL HHHHCCHHHHHHHHH	26.11	46159677
157	Phosphorylation	VGAVSTASHLLVLGS HHCCHHHHHHHHHHH	18.11	46159665
214	Ubiquitination	DLFTYTVKCIQIRRK HHHHHHHHHHHHHHH	20.16	-
273	Ubiquitination	NFHSLYVKRHQNVSI CCCHHHHCCCCCCEE	30.52	-
316	Ubiquitination	GKFDQIAKANECMRI CCHHHHHHHHCCEEE	54.06	-
324	Ubiquitination	ANECMRIKILGDCYY HHCCEEEEEECCCEE	22.86	-
349	Ubiquitination	THARNCVKMGLDMCQ HHHHHHHHHCHHHHH	29.47	-
359	Ubiquitination	LDMCQAIKQVREATG HHHHHHHHHHHHHHC	45.84	-
365	Phosphorylation	IKQVREATGVDINMR HHHHHHHHCCCCEEE	32.74	10486863
389	Ubiquitination	CGVIGLRKWQYDVWS EEEEEEEECEEEECC	43.63	-
422	Ubiquitination	HITEATLKHLDKAYE EEEHHHHHHHHHHEE	37.45	21890473
422	Acetylation	HITEATLKHLDKAYE EEEHHHHHHHHHHEE	37.45	20167786
426	Acetylation	ATLKHLDKAYEVEDG HHHHHHHHHEECCCC	60.26	20167786
426	Ubiquitination	ATLKHLDKAYEVEDG HHHHHHHHHEECCCC	60.26	-
443	Ubiquitination	QQRDPYLKEMNIRTY CCCCHHHHHCCCCEE	49.42	21890473
477	Ubiquitination	PKGDAALKMRASVRM CCCCHHHHHHHHHHH	22.93	-
490	Phosphorylation	RMTRYLESWGAARPF HHHHHHHHCCCCCCC	28.37	101661943
505	Phosphorylation	AHLNHRESVSSGETH CCCCCCCCCCCCCCC	27.53	82900321
507	Phosphorylation	LNHRESVSSGETHVP CCCCCCCCCCCCCCC	41.74	28450419
508	Phosphorylation	NHRESVSSGETHVPN CCCCCCCCCCCCCCC	38.19	28450419
511	Phosphorylation	ESVSSGETHVPNGRR CCCCCCCCCCCCCCC	31.53	28450419
535	Phosphorylation	RTPDRSMSPKGRSED CCCCCCCCCCCCCCC	25.38	113310213
570	Phosphorylation	CSKSDDFYTFGSIFL CCCCCCCEEECHHHH	14.25	27642862
579	Ubiquitination	FGSIFLEKGFEREYR ECHHHHHCCCCCEEE	71.67	-
701	N-linked_Glycosylation	VPELPVGNETGLLAA CCCCCCCCCCCCCCC	43.84	UniProtKB CARBOHYD
776	N-linked_Glycosylation	CCGQGLGNLTKPNGT CCCCCCCCCCCCCCC	49.97	UniProtKB CARBOHYD
781	N-linked_Glycosylation	LGNLTKPNGTTSGTP CCCCCCCCCCCCCCC	63.10	UniProtKB CARBOHYD
783	Phosphorylation	NLTKPNGTTSGTPSC CCCCCCCCCCCCCCC	25.16	24043423
784	Phosphorylation	LTKPNGTTSGTPSCS CCCCCCCCCCCCCCC	26.93	24043423
785	Phosphorylation	TKPNGTTSGTPSCSW CCCCCCCCCCCCCCH	40.27	24043423
787	Phosphorylation	PNGTTSGTPSCSWKD CCCCCCCCCCCCHHH	16.28	24043423
789	Phosphorylation	GTTSGTPSCSWKDLK CCCCCCCCCCHHHHH	22.18	24043423
791	Phosphorylation	TSGTPSCSWKDLKTM CCCCCCCCHHHHHHH	41.31	24043423
797	Phosphorylation	CSWKDLKTMTNFYLV CCHHHHHHHHHHHHH	36.20	24043423
799	Phosphorylation	WKDLKTMTNFYLVLF HHHHHHHHHHHHHHH	27.66	24043423
802	Phosphorylation	LKTMTNFYLVLFYIT HHHHHHHHHHHHHHH	9.66	24043423
807	Phosphorylation	NFYLVLFYITLLTLS HHHHHHHHHHHHHHH	6.71	24043423
809	Phosphorylation	YLVLFYITLLTLSRQ HHHHHHHHHHHHHHH	12.34	24043423
812	Phosphorylation	LFYITLLTLSRQIDY HHHHHHHHHHHHHHH	26.29	24043423
814	Phosphorylation	YITLLTLSRQIDYYC HHHHHHHHHHHHHHH	19.53	46159671
832	Ubiquitination	CLWKKKFKKEHEEFE HHHHHHHHHHHHHHH	67.16	-
833	Ubiquitination	LWKKKFKKEHEEFET HHHHHHHHHHHHHHH	68.39	-
892	Phosphorylation	VPDFKVFYTECDVNK CCCEEEEEEECCCCH	12.48	25884760
899	Ubiquitination	YTECDVNKEGLECLR EEECCCCHHHHHHHH	53.67	-
925	Phosphorylation	LLLKPKFSGVEKIKT HHHCCCCCCCCCCEE	48.32	24719451
929	Ubiquitination	PKFSGVEKIKTIGST CCCCCCCCCEECCHH	47.28	-
982	Phosphorylation	LDGINRHSFNSFRLR CCCCCCCCCCEEEEE	23.92	30266825
985	Phosphorylation	INRHSFNSFRLRVGI CCCCCCCEEEEEEEC	15.10	30266825
1006	Ubiquitination	AGVIGARKPQYDIWG EEEECCCCCCCCCCC	35.62	21890473
1057	Ubiquitination	CRGLINVKGKGELRT EECEEEECCCCEEEE	50.87	-
1073	Ubiquitination	FVCTDTAKFQGLGLN EEECCCHHHCCCCCC	40.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADCY7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADCY7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
443	Ubiquitination	439 (4)	D ⇒ E	rs78534766	Ulcerative colitis	28067908

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRCC6_HUMAN	XRCC6	physical	21988832
PLS1_HUMAN	PLSCR1	physical	21988832
BUD31_HUMAN	BUD31	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D01697: Colforsin daropate hydrochloride (JAN); Nkh 477; Adehl (TN)
• DrugBank
• There are no disease associations of PTM sites.