ADCY5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADCY5_RAT
• UniProt AC: Q04400
• Protein Name: Adenylate cyclase type 5
• Gene Name: Adcy5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1262
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, cilium .
• Protein Description: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. [PubMed: 1409703 Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion.]
• Protein Sequence: MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGAVTPQQQQRLASRWRGGDDDEDPPLSGDDPLVGGFGFSFRSKSAWQERGGDDGGRGSRRQRRGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVEVGLEERRGKGRAAEELEPGTGTVEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISSVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSGSKSVSPPGYA --CCCCCCCCCCCHH	29.53	25403869
8	Phosphorylation	MSGSKSVSPPGYAAQ CCCCCCCCCCCHHHH	32.25	25403869
23	Methylation	TAASPAPRGGPEHRA CCCCCCCCCCHHHHH	65.88	-
62	Phosphorylation	KRSGGAVTPQQQQRL CCCCCCCCHHHHHHH	18.17	30411139
97	Phosphorylation	LVGGFGFSFRSKSAW CCCCCCEEEECCHHH	21.82	-
101	Succinylation	FGFSFRSKSAWQERG CCEEEECCHHHHHCC	39.68	26843850
156	Phosphorylation	GTEVRPRSVEVGLEE CCEECCCCCCCCCHH	25.88	28432305
637	Phosphorylation	NAYLKEHSIETFLIL CHHCHHCCHHHHHHH	24.18	25575281
640	Phosphorylation	LKEHSIETFLILRCT CHHCCHHHHHHHHHC	23.28	25575281
665	Phosphorylation	AKMNRQRTNSIGHNP HHHHHHHCCCCCCCC	25.61	25575281
667	Phosphorylation	MNRQRTNSIGHNPPH HHHHHCCCCCCCCCC	29.36	25575281
705	Ubiquitination	GFEDPKDKNAQESAN CCCCCCCCCHHHHCC	61.38	-
729	Phosphorylation	GRAIDARSIDRLRSE HHHHCHHHHHHHHHH	30.48	26022182
755	Phosphorylation	PDLEKKYSKQVDDRF CCHHHHHHHHCHHHH	26.03	-
871	N-linked_Glycosylation	GCLAEEHNITVNQVN HHHHHHCCCCHHCHH	34.60	-
888	N-linked_Glycosylation	HVMESAFNYSLGDEQ HHHHHHHCCCCCCCC	25.79	-
973	N-linked_Glycosylation	NAIDFSNNGTSQCPE CEEECCCCCCCCCCH	54.65	-
1012	Phosphorylation	HAQQVESTARLDFLW HHHHHHHHHHHHHHH	11.42	11877398

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADCY5_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADCY5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADCY5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ADCY5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.