ADCY4_HUMAN - dbPTM
ADCY4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADCY4_HUMAN
UniProt AC Q8NFM4
Protein Name Adenylate cyclase type 4
Gene Name ADCY4
Organism Homo sapiens (Human).
Sequence Length 1077
Subcellular Localization Cell membrane
Multi-pass membrane protein . Cytoplasm .
Protein Description Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling..
Protein Sequence MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MARLFSPRPPPSE
--CCCCCCCCCCCCH		25.2922265059
24 (in isoform 2)Phosphorylation-14.8622210691
40 (in isoform 2)Phosphorylation-8.9622210691
41 (in isoform 2)Phosphorylation-2.5322210691
159PhosphorylationHLLVLGLYLGPQPDS
HHHHHHHHHCCCCCC		14.0726074081
166PhosphorylationYLGPQPDSRPALLPQ
HHCCCCCCCCCHHHH		47.0126074081
208PhosphorylationATFREALSSLHSRRR
HHHHHHHHHHHHHCC		37.5927251275
209PhosphorylationTFREALSSLHSRRRL
HHHHHHHHHHHHCCC		30.8327251275
212PhosphorylationEALSSLHSRRRLDTE
HHHHHHHHHCCCCCC		32.5427251275
253PhosphorylationRLQAGQGSRPESTNN
HHHCCCCCCCCCCCC		36.4546159593
267UbiquitinationNFHSLYVKRHQGVSV
CCCHHHEECCCCCEE		30.52-
444PhosphorylationRELGEPTYLVIDPRA
HHHCCCEEEEECCCC		15.0855213
459PhosphorylationEEEDEKGTAGGLLSS
CCCCCCCCHHHHHHH		32.9546159599
479PhosphorylationMRPSLLMTRYLESWG
CCHHHHHHHHHHHCC		19.0129759185
489AcetylationLESWGAAKPFAHLSH
HHHCCCCCCCCCCCC		39.887826119
499PhosphorylationAHLSHGDSPVSTSTP
CCCCCCCCCCCCCCC		31.6223312004
520PhosphorylationASFSTQWSLDRSRTP
CHHHHCCCCCCCCCC		15.58-
536PhosphorylationGLDDELDTGDAKFFQ
CCCCCCCCCCHHHHH		49.9724501219
576PhosphorylationEKEMEKEYRLSAIPA
HHHHHHHHHHCCCCH		28.1128509920
579PhosphorylationMEKEYRLSAIPAFKY
HHHHHHHCCCCHHHH		18.3628509920
586PhosphorylationSAIPAFKYYEACTFL
CCCCHHHHHHHHHHH		10.4924043423
587PhosphorylationAIPAFKYYEACTFLV
CCCHHHHHHHHHHHH		9.5324043423
591PhosphorylationFKYYEACTFLVFLSN
HHHHHHHHHHHHHHH		27.3524043423
597PhosphorylationCTFLVFLSNFIIQML
HHHHHHHHHHHHHHH		20.4524043423
606PhosphorylationFIIQMLVTNRPPALA
HHHHHHHHCCCCHHH		22.8824043423
697N-linked_GlycosylationDCPFQAPNVSSMISN
CCCCCCCCHHHHHHH		49.68UniProtKB CARBOHYD
704N-linked_GlycosylationNVSSMISNLSWELPG
CHHHHHHHHCCCCCC		27.46UniProtKB CARBOHYD
812PhosphorylationVLARQNEYYCRLDFL
HHHHCCCCHHHHHHH		18.5324043423
813PhosphorylationLARQNEYYCRLDFLW
HHHCCCCHHHHHHHH		2.4924043423
914PhosphorylationADFDELLSKPKFSGV
HCHHHHHCCCCCCCC		60.5824719451
919PhosphorylationLLSKPKFSGVEKIKT
HHCCCCCCCCCCCEE		48.3224719451
923UbiquitinationPKFSGVEKIKTIGST
CCCCCCCCCEECCCH		47.28-
1001UbiquitinationAGVIGAQKPQYDIWG
EEEECCCCCCCCCCC		33.29-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADCY4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADCY4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADCY4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ADCY4_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D01697 Colforsin daropate hydrochloride (JAN); Nkh 477; Adehl (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADCY4_HUMAN

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Related Literatures of Post-Translational Modification

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