ADCY3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADCY3_RAT
• UniProt AC: P21932
• Protein Name: Adenylate cyclase type 3
• Gene Name: Adcy3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1144
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Golgi apparatus . Cell projection, cilium . Cytoplasm .
• Protein Description: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. [PubMed: 2255909]
• Protein Sequence: MTEDQGFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGVGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLITAQIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPEVKKTAQNGLNGSALPNGAPASKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRAFPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNVTTGIELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTAINLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLSTPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSVTLPHQVVDNP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
428	Acetylation	LGGVLGQKRWQYDVW HHCHHCCCCCEEEEE	54.53	25786129
465	Sumoylation	QSTMDCLKGEFDVEP HHHHHHHCCCCCCCC	63.83	25908845
523	Phosphorylation	APASKPSSPALIETK CCCCCCCCCCEEEEC	23.79	-
578	Phosphorylation	ADRVVDASEDEHELN HHHHCCCCCCHHHHH	40.91	-
734	N-linked_Glycosylation	QYYMGPYNVTTGIEL HHHHCCCCCCCCEEE	28.00	-
810	Phosphorylation	KRFQEKDSPMVALEK HHHHCCCCCCHHHHH	26.43	26022182
878	Ubiquitination	KIEVHDQKERVYEMR EEEECCHHHHHHHHH	54.25	-
1076	Phosphorylation	NVASRMESTGVMGNI EHHHHHHHCCCCCCE	22.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1076	S	Phosphorylation	Kinase	CAMK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1076	S	Phosphorylation	Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADCY3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ADCY3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.