dbPTM

ADCY2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ADCY2_RAT
UniProt AC	P26769
Protein Name	Adenylate cyclase type 2
Gene Name	Adcy2
Organism	Rattus norvegicus (Rat).
Sequence Length	1090
Subcellular Localization	Membrane Multi-pass membrane protein . Cell membrane Multi-pass membrane protein . Cytoplasm .
Protein Description	Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. [PubMed: 22906005]
Protein Sequence	MRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCMSQQHPLIVFLLLIVMGACLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASILTSSSHTIVLSVYLSATPGAKEHLFWQILANVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASTSLMWLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANTSNANVSVPDNQASILHARNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLDAYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNLAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
471	Phosphorylation	NPKGERRSPQHLFRP CCCCCCCCCCCCCCC	34.82	30411139
490	Phosphorylation	DGAKMRASVRMTRYL CHHHHHHHHHHHHHH	10.41	22906005
543	Phosphorylation	NRTLRTKSQKKRFEE CCCCCCHHHHHHHHH	46.77	22906005
712	N-linked_Glycosylation	ETTLPTANTSNANVS CCCCCCCCCCCCEEC	46.66	-
717	N-linked_Glycosylation	TANTSNANVSVPDNQ CCCCCCCEECCCCCH	30.74	-
838	Ubiquitination	FLWKNKFKKEREEIE HHHCCCCHHHHHHHH	56.16	-
839	Ubiquitination	LWKNKFKKEREEIET HHCCCCHHHHHHHHH	66.20	-
871	Phosphorylation	AEHFLARSLKNEELY HHHHHHHHCCCHHHH	37.78	9366262
1057	Phosphorylation	QTLGYTCTCRGIINV HHHCCCEEEEEEEEE	9.46	9366262
1071	Acetylation	VKGKGDLKTYFVNTE ECCCCCEEEEEECHH	46.01	22902405
1082	Phosphorylation	VNTEMSRSLSQSNLA ECHHHHHHHHHHCCC	25.68	27097102
1084	Phosphorylation	TEMSRSLSQSNLAS- HHHHHHHHHHCCCC-	32.58	27097102
1086	Phosphorylation	MSRSLSQSNLAS--- HHHHHHHHCCCC---	30.36	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
490	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
490	S	Phosphorylation	Kinase	PKC	-	Uniprot
543	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
543	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ADCY2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ADCY2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ADCY2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ADCY2_RAT

Related Literatures of Post-Translational Modification