| UniProt ID | ADA2_HUMAN | |
|---|---|---|
| UniProt AC | Q9NZK5 | |
| Protein Name | Adenosine deaminase 2 {ECO:0000312|HGNC:HGNC:1839} | |
| Gene Name | ADA2 {ECO:0000312|HGNC:HGNC:1839} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 511 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.. | |
| Protein Sequence | MLVDGPSERPALCFLLLAVAMSFFGSALSIDETRAHLLLKEKMMRLGGRLVLNTKEELANERLMTLKIAEMKEAMRTLIFPPSMHFFQAKHLIERSQVFNILRMMPKGAALHLHDIGIVTMDWLVRNVTYRPHCHICFTPRGIMQFRFAHPTPRPSEKCSKWILLEDYRKRVQNVTEFDDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYVFRSMQEFYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKDVAVIAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKDGVKLPYFFHAGETDWQGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVATLMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTLLESEKNTFMEIWKKRWDKFIADVATK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Phosphorylation | LLLAVAMSFFGSALS HHHHHHHHHHCCCCC | 46185201 | ||
| 26 | Phosphorylation | VAMSFFGSALSIDET HHHHHHCCCCCCHHH | 46185205 | ||
| 40 | Ubiquitination | TRAHLLLKEKMMRLG HHHHHHHHHHHHHCC | - | ||
| 55 | Ubiquitination | GRLVLNTKEELANER CEEEECCHHHHHHHH | - | ||
| 65 | O-linked_Glycosylation | LANERLMTLKIAEMK HHHHHHCHHHHHHHH | 30620550 | ||
| 67 | Ubiquitination | NERLMTLKIAEMKEA HHHHCHHHHHHHHHH | - | ||
| 72 | Ubiquitination | TLKIAEMKEAMRTLI HHHHHHHHHHHHHHH | - | ||
| 96 | Phosphorylation | AKHLIERSQVFNILR HHHHHHHHHHHHHHH | 68732545 | ||
| 120 | Phosphorylation | LHDIGIVTMDWLVRN HHHCEEEEHHHHHHC | 68732549 | ||
| 127 | N-linked_Glycosylation | TMDWLVRNVTYRPHC EHHHHHHCCCCCCCC | 20147294 | ||
| 158 | Ubiquitination | PTPRPSEKCSKWILL CCCCCCHHHCCEEEH | - | ||
| 161 | Ubiquitination | RPSEKCSKWILLEDY CCCHHHCCEEEHHHH | - | ||
| 174 | N-linked_Glycosylation | DYRKRVQNVTEFDDS HHHHHHCCCCCCCHH | 19159218 | ||
| 181 | Phosphorylation | NVTEFDDSLLRNFTL CCCCCCHHHHHCCEE | 24719451 | ||
| 185 | N-linked_Glycosylation | FDDSLLRNFTLVTQH CCHHHHHCCEEEECC | 20147294 | ||
| 267 | Ubiquitination | HDEEWSVKTYQEVAQ CCCCCHHHHHHHHHH | - | ||
| 275 | Ubiquitination | TYQEVAQKFVETHPE HHHHHHHHHHHHCHH | - | ||
| 287 | Ubiquitination | HPEFIGIKIIYSDHR CHHHEEEEEEEECCC | - | ||
| 290 | Phosphorylation | FIGIKIIYSDHRSKD HEEEEEEEECCCCCC | 29449344 | ||
| 291 | Phosphorylation | IGIKIIYSDHRSKDV EEEEEEEECCCCCCH | 29449344 | ||
| 296 | Ubiquitination | IYSDHRSKDVAVIAE EEECCCCCCHHHHHH | - | ||
| 330 | Phosphorylation | DLVGHEDTGHSLHDY EEECCCCCCCCCCCH | 19835603 | ||
| 333 | Phosphorylation | GHEDTGHSLHDYKEA CCCCCCCCCCCHHHH | 19835603 | ||
| 337 | Phosphorylation | TGHSLHDYKEALMIP CCCCCCCHHHHHEEE | 27660739 | ||
| 346 | Ubiquitination | EALMIPAKDGVKLPY HHHEEECCCCCCCCE | - | ||
| 350 | Ubiquitination | IPAKDGVKLPYFFHA EECCCCCCCCEEEEC | - | ||
| 378 | N-linked_Glycosylation | ILDALMLNTTRIGHG HHHHHHCCCCEECCC | 20147294 | ||
| 390 | Ubiquitination | GHGFALSKHPAVRTY CCCCCCCCCCCCEEC | - | ||
| 397 | Phosphorylation | KHPAVRTYSWKKDIP CCCCCEECCCCCCCC | 46185213 | ||
| 398 | Phosphorylation | HPAVRTYSWKKDIPI CCCCEECCCCCCCCE | 46185209 | ||
| 401 | Ubiquitination | VRTYSWKKDIPIEVC CEECCCCCCCCEEEE | - | ||
| 416 | Ubiquitination | PISNQVLKLVSDLRN CCCHHHHHHHHHHHC | - | ||
| 482 | Phosphorylation | LAMNSIKYSTLLESE HHHHHCCHHHHHHHC | 22617229 | ||
| 488 | Phosphorylation | KYSTLLESEKNTFME CHHHHHHHCCCCHHH | 22617229 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ADA2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ADA2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ADA2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ADA2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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