dbPTM

ADA10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ADA10_MOUSE
UniProt AC	O35598
Protein Name	Disintegrin and metalloproteinase domain-containing protein 10
Gene Name	Adam10
Organism	Mus musculus (Mouse).
Sequence Length	749
Subcellular Localization	Cell membrane Single-pass type I membrane protein . Golgi apparatus membrane Single-pass type I membrane protein . Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived
Protein Description	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-\|-Leu-688' (By similarity). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. [PubMed: 9244301 Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (By similarity Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity May regulate the EFNA5-EPHA3 signaling (By similarity]
Protein Sequence	MVLPTVLILLLSWAAGLGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLLLDFHAHGRQFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIKTRGGTFYIEPAERYIKDRILPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEGARAHPEKHAASSGPELLRKKRTTLAERNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTSDEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDDCCFDANQPEGKKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAKEGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYDLEECTCASSDGKDDKELCHVCCMKKMAPSTCASTGSLQWSKQFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPQLYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPPRQRPRESYQMGHMRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
223	S-palmitoylation	TLAERNTCQLYIQTD HHHHCCCEEEEEECC	2.75	26165157
268	N-linked_Glycosylation	TDFSGIRNISFMVKR CCCCCCCCEEEEEEE	32.13	-
279	N-linked_Glycosylation	MVKRIRINTTSDEKD EEEEEEECCCCCCCC	27.70	19349973
356	Acetylation	KLYSDGKKKSLNTGI CCCCCCCCCCCCCCE	53.80	7718011
411	Acetylation	ESKNLGQKENGNYIM CCCCCCCCCCCCEEE	51.88	6568753
437	Phosphorylation	NNKFSLCSIRNISQV CCEEEEHHHHCHHHH	29.85	22817900
440	N-linked_Glycosylation	FSLCSIRNISQVLEK EEEHHHHCHHHHHHH	36.27	-
442	Phosphorylation	LCSIRNISQVLEKKR EHHHHCHHHHHHHHC	20.13	27149854
447	Ubiquitination	NISQVLEKKRNNCFV CHHHHHHHHCCCCEE	53.52	22790023
552	N-linked_Glycosylation	PASDPKPNFTDCNRH CCCCCCCCCCCCCCC	59.58	-
720	Phosphorylation	PPKPLPGTLKRRRPP CCCCCCCCCCCCCCC	27.45	27180971
741	Phosphorylation	PRQRPRESYQMGHMR CCCCCCHHHCCCCCC	23.19	30803983
742	Phosphorylation	RQRPRESYQMGHMRR CCCCCHHHCCCCCCC	9.58	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ADA10_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ADA10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ADA10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DLG1_MOUSE	Dlg1	physical	17301176

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ADA10_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279, AND MASSSPECTROMETRY.	19349973 [Abstract]