ACTB_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTB_CHICK
• UniProt AC: P60706
• Protein Name: Actin, cytoplasmic 1
• Gene Name: ACTB
• Organism: Gallus gallus (Chicken).
• Sequence Length: 375
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells..
• Protein Sequence: MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDDDIAAL -------CCCCCEEE	13.23	-
2	Acetylation	------MDDDIAALV ------CCCCCEEEE	63.39	-
44	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	-
47	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	-
73	Methylation	TLKYPIEHGIVTNWD EEECEECCCCCCCHH	31.81	11955010

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACTB_CHICK !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACTB_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTB_CHICK !!

Protein-Protein Interaction

Oops, there are no PPI records of ACTB_CHICK !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.