ACSM2_MOUSE - dbPTM
ACSM2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACSM2_MOUSE
UniProt AC Q8K0L3
Protein Name Acyl-coenzyme A synthetase ACSM2, mitochondrial
Gene Name Acsm2
Organism Mus musculus (Mouse).
Sequence Length 575
Subcellular Localization Mitochondrion matrix.
Protein Description Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity)..
Protein Sequence MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56PhosphorylationDVIDHWASVEKAGKR
HHHHHHHHHHHCCCC		26.1425195567
59 (in isoform 2)Ubiquitination-61.3522790023
59UbiquitinationDHWASVEKAGKRSSG
HHHHHHHHCCCCCCC		61.3522790023
64PhosphorylationVEKAGKRSSGPALWW
HHHCCCCCCCCEEEE		43.0321082442
65PhosphorylationEKAGKRSSGPALWWM
HHCCCCCCCCEEEEE		53.4821183079
75PhosphorylationALWWMNGSGKEIKWS
EEEEECCCCCEEEEE		41.5122817900
84 (in isoform 2)Ubiquitination-38.13-
143PhosphorylationGTIQMRSSDILYRLQ
CEEEECCCHHHHHHH		20.5025195567
147PhosphorylationMRSSDILYRLQASKA
ECCCHHHHHHHHHCC		15.0425195567
175PhosphorylationDAVAPDCSFLKIKLL
CHHCCCCCEEEEEEE		40.7826643407
178 (in isoform 2)Ubiquitination-35.4722790023
178UbiquitinationAPDCSFLKIKLLVSE
CCCCCEEEEEEEECC		35.4722790023
180 (in isoform 2)Ubiquitination-33.8922790023
180UbiquitinationDCSFLKIKLLVSENS
CCCEEEEEEEECCCC		33.8922790023
184PhosphorylationLKIKLLVSENSREGW
EEEEEEECCCCCCCC		30.9128066266
187PhosphorylationKLLVSENSREGWLNF
EEEECCCCCCCCCCH		27.8825195567
199 (in isoform 2)Ubiquitination-52.6822790023
199UbiquitinationLNFKALLKEASTIHQ
CCHHHHHHHHHHHHH		52.6822790023
203 (in isoform 2)Ubiquitination-29.53-
205 (in isoform 2)Ubiquitination-18.31-
224 (in isoform 2)Ubiquitination-30.22-
225PhosphorylationIYFTSGTSGPPKMAE
EEEECCCCCCCCCHH		53.4825195567
353 (in isoform 2)Ubiquitination-39.1222790023
353UbiquitinationTLENWKAKTGLEIRE
HHHHHHHHCCCCHHH		39.1222790023
378 (in isoform 2)Ubiquitination-46.63-
451 (in isoform 2)Ubiquitination-70.7922790023
451UbiquitinationLMGDRGIKDPEGYFH
EEECCCCCCCCCCEE		70.7922790023
456PhosphorylationGIKDPEGYFHFIGRS
CCCCCCCCEEEECCC		7.6925195567
472PhosphorylationDIINSSGYRIGPSEV
CCCCCCCCCCCHHHH		10.8725195567
476 (in isoform 2)Ubiquitination-25.58-
518PhosphorylationVLAPEFLSHDRDQLT
EECHHHHCCCHHHHH		28.7625195567
525PhosphorylationSHDRDQLTKVLQEHV
CCCHHHHHHHHHHHH		17.3021183079
539PhosphorylationVKSVTAPYKYPRKVE
HHHCCCCCCCCCEEE		22.2326032504
540MalonylationKSVTAPYKYPRKVEF
HHCCCCCCCCCEEEE		47.9526320211
540SuccinylationKSVTAPYKYPRKVEF
HHCCCCCCCCCEEEE		47.9523806337
540AcetylationKSVTAPYKYPRKVEF
HHCCCCCCCCCEEEE		47.9523864654
541PhosphorylationSVTAPYKYPRKVEFV
HCCCCCCCCCEEEEE		11.486867263
556PhosphorylationLDLPKTVTGKIERAK
EECCHHHCCHHHHHH		37.6820139300
558UbiquitinationLPKTVTGKIERAKLR
CCHHHCCHHHHHHHH		31.8422790023
558 (in isoform 2)Ubiquitination-31.8422790023
583 (in isoform 2)Ubiquitination--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACSM2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACSM2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACSM2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ACSM2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACSM2_MOUSE

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Related Literatures of Post-Translational Modification

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