| UniProt ID | ACRO_HUMAN | |
|---|---|---|
| UniProt AC | P10323 | |
| Protein Name | Acrosin | |
| Gene Name | ACR | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 421 | |
| Subcellular Localization | ||
| Protein Description | Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.. | |
| Protein Sequence | MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTSTS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | N-linked_Glycosylation | VSVVAKDNATCDGPC HHHHHCCCCCCCCCC | 36.12 | UniProtKB CARBOHYD | |
| 59 | Phosphorylation | GAWPWMVSLQIFTYN CCCCCEEEEEEEEEC | 9.84 | 30622161 | |
| 133 | Acetylation | EKIIIHEKYNSATEG EEEEEECCCCCCCCC | 35.25 | 25038526 | |
| 193 | Phosphorylation | EEKAPRPSSILMEAR CCCCCCCCHHHEEEE | 31.15 | 30622161 | |
| 194 | Phosphorylation | EKAPRPSSILMEARV CCCCCCCHHHEEEEE | 23.56 | 30622161 | |
| 210 | N-linked_Glycosylation | LIDLDLCNSTQWYNG EEEHHCCCCCCCCCC | 56.22 | UniProtKB CARBOHYD | |
| 249 | Phosphorylation | GPLMCKDSKESAYVV CCEEECCCCCCCEEE | 24.66 | 30622161 | |
| 252 | Phosphorylation | MCKDSKESAYVVVGI EECCCCCCCEEEEEE | 28.74 | 27251275 | |
| 254 | Phosphorylation | KDSKESAYVVVGITS CCCCCCCEEEEEEEE | 11.76 | 27251275 | |
| 299 | Phosphorylation | NALRMIQSATPPPPT HHHHHHHHCCCCCCC | 24.16 | 22210691 | |
| 301 | Phosphorylation | LRMIQSATPPPPTTR HHHHHHCCCCCCCCC | 41.39 | 22210691 | |
| 306 | Phosphorylation | SATPPPPTTRPPPIR HCCCCCCCCCCCCCC | 41.01 | 22210691 | |
| 349 | Phosphorylation | AQPRPPPSPPPPPPP CCCCCCCCCCCCCCC | 56.67 | 16094384 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACRO_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACRO_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACRO_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ACRO_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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