ACOX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACOX1_MOUSE
• UniProt AC: Q9R0H0
• Protein Name: Peroxisomal acyl-coenzyme A oxidase 1 {ECO:0000250|UniProtKB:Q15067}
• Gene Name: Acox1 {ECO:0000312|MGI:MGI:1330812}
• Organism: Mus musculus (Mouse).
• Sequence Length: 661
• Subcellular Localization: Peroxisome .
• Protein Description: Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity)..
• Protein Sequence: MNPDLRKERAAATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRYEVAVKKSATMVKKMREFGIADPEEIMWFKKLHMVNFVEPVGLNYSMFIPTLLNQGTTAQQEKWMHPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITRGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGSAAQSLSKACTIAIRYSAVRRQSEIKRSEPEPQILDFQTQQYKLFPLLATAYAFHFLGRYIKETYMRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVQSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTLVDINSLDSLTEAYKLRAARLVEIAAKNLQAQVSHRKSKEVAWNLTSVDLVRASEAHCHYVTVKVFADKLPKIQDRAVQAVLRNLCLLYSLYGISQKGGDFLEGNIITGAQMSQVNSRILELLTVTRPNAVALVDAFDFKDVTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYYKHLKPLQSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	TFNPELITHILDGSP HCCHHHHHHHHCCCC	18.58	21183079
26	Phosphorylation	ITHILDGSPENTRRR HHHHHCCCCCHHHHH	28.80	21082442
30	Phosphorylation	LDGSPENTRRRREIE HCCCCCHHHHHHHHH	24.72	19060867
51	Phosphorylation	PDFQHEDYNFLTRSQ CCCCCCCCCHHCHHH	12.58	8234233
57	Phosphorylation	DYNFLTRSQRYEVAV CCCHHCHHHHHEEEE	17.49	30352176
60	Phosphorylation	FLTRSQRYEVAVKKS HHCHHHHHEEEEHHH	13.71	29472430
65	Acetylation	QRYEVAVKKSATMVK HHHEEEEHHHHHHHH	31.13	23576753
65	Glutarylation	QRYEVAVKKSATMVK HHHEEEEHHHHHHHH	31.13	24703693
65	Ubiquitination	QRYEVAVKKSATMVK HHHEEEEHHHHHHHH	31.13	27667366
69	Phosphorylation	VAVKKSATMVKKMRE EEEHHHHHHHHHHHH	29.59	59149931
72	Acetylation	KKSATMVKKMREFGI HHHHHHHHHHHHHCC	29.99	23864654
89	Acetylation	PEEIMWFKKLHMVNF HHHHHHHEECCCCCC	38.62	23806337
89	Succinylation	PEEIMWFKKLHMVNF HHHHHHHEECCCCCC	38.62	-
89	Succinylation	PEEIMWFKKLHMVNF HHHHHHHEECCCCCC	38.62	23806337
89	Ubiquitination	PEEIMWFKKLHMVNF HHHHHHHEECCCCCC	38.62	-
89 (in isoform 2)	Ubiquitination	-	38.62	-
90	Acetylation	EEIMWFKKLHMVNFV HHHHHHEECCCCCCC	33.86	23806337
90	Succinylation	EEIMWFKKLHMVNFV HHHHHHEECCCCCCC	33.86	-
90	Succinylation	EEIMWFKKLHMVNFV HHHHHHEECCCCCCC	33.86	23806337
90	Ubiquitination	EEIMWFKKLHMVNFV HHHHHHEECCCCCCC	33.86	-
148	Ubiquitination	MGHGTHLRGLETTAT CCCCCEECCCEEEEE	39.79	27667366
159	Acetylation	TTATYDPKTQEFILN EEEEECCCCCEEECC	61.00	23864654
159	Succinylation	TTATYDPKTQEFILN EEEEECCCCCEEECC	61.00	-
159	Succinylation	TTATYDPKTQEFILN EEEEECCCCCEEECC	61.00	23806337
159	Ubiquitination	TTATYDPKTQEFILN EEEEECCCCCEEECC	61.00	-
174	Acetylation	SPTVTSIKWWPGGLG CCCEEEEEECCCCCC	42.86	23954790
174	Ubiquitination	SPTVTSIKWWPGGLG CCCEEEEEECCCCCC	42.86	22790023
182	Acetylation	WWPGGLGKTSNHAIV ECCCCCCCCCCHHHH	54.55	23864654
187	Ubiquitination	LGKTSNHAIVLAQLI CCCCCCHHHHHHHHH	9.61	27667366
192	Ubiquitination	NHAIVLAQLITRGEC CHHHHHHHHHHCCCC	29.27	27667366
199	S-nitrosocysteine	QLITRGECYGLHAFV HHHHCCCCCCEEEEE	3.48	-
199	S-nitrosylation	QLITRGECYGLHAFV HHHHCCCCCCEEEEE	3.48	21278135
199	S-palmitoylation	QLITRGECYGLHAFV HHHHCCCCCCEEEEE	3.48	26165157
199	Ubiquitination	QLITRGECYGLHAFV HHHHCCCCCCEEEEE	3.48	27667366
200	Phosphorylation	LITRGECYGLHAFVV HHHCCCCCCEEEEEE	20.58	25195567
216	Acetylation	IREIGTHKPLPGITV HHHCCCCCCCCCCEE	48.35	23576753
216	Succinylation	IREIGTHKPLPGITV HHHCCCCCCCCCCEE	48.35	24315375
216	Ubiquitination	IREIGTHKPLPGITV HHHCCCCCCCCCCEE	48.35	27667366
229	Acetylation	TVGDIGPKFGYEEMD EEECCCHHCCCCCCC	46.32	23864654
229	Ubiquitination	TVGDIGPKFGYEEMD EEECCCHHCCCCCCC	46.32	22790023
232	Phosphorylation	DIGPKFGYEEMDNGY CCCHHCCCCCCCCCE	16.32	17242355
241	Acetylation	EMDNGYLKMDNYRIP CCCCCEECCCCCCCC	35.41	23806337
241	Succinylation	EMDNGYLKMDNYRIP CCCCCEECCCCCCCC	35.41	-
241	Succinylation	EMDNGYLKMDNYRIP CCCCCEECCCCCCCC	35.41	23806337
241	Ubiquitination	EMDNGYLKMDNYRIP CCCCCEECCCCCCCC	35.41	-
246	Dimethylation	YLKMDNYRIPRENML EECCCCCCCCCHHHC	38.39	-
255	Acetylation	PRENMLMKYAQVKPD CCHHHCHHHEEECCC	33.21	23201123
255	Ubiquitination	PRENMLMKYAQVKPD CCHHHCHHHEEECCC	33.21	27667366
256	Phosphorylation	RENMLMKYAQVKPDG CHHHCHHHEEECCCC	6.57	25195567
260	Acetylation	LMKYAQVKPDGTYVK CHHHEEECCCCCEEE	25.88	23864654
260	Malonylation	LMKYAQVKPDGTYVK CHHHEEECCCCCEEE	25.88	26320211
260	Ubiquitination	LMKYAQVKPDGTYVK CHHHEEECCCCCEEE	25.88	27667366
267	Acetylation	KPDGTYVKPLSNKLT CCCCCEEEECCCCCC	29.81	23576753
267	Malonylation	KPDGTYVKPLSNKLT CCCCCEEEECCCCCC	29.81	26320211
267	Ubiquitination	KPDGTYVKPLSNKLT CCCCCEEEECCCCCC	29.81	27667366
272	Acetylation	YVKPLSNKLTYGTMV EEEECCCCCCHHCCH	38.54	23576753
272	Ubiquitination	YVKPLSNKLTYGTMV EEEECCCCCCHHCCH	38.54	22790023
275	Phosphorylation	PLSNKLTYGTMVFVR ECCCCCCHHCCHHHH	22.49	17242355
281	Ubiquitination	TYGTMVFVRSFLVGS CHHCCHHHHHHHHHH	3.22	27667366
288	Phosphorylation	VRSFLVGSAAQSLSK HHHHHHHHHHHHHHH	16.98	29472430
292	Phosphorylation	LVGSAAQSLSKACTI HHHHHHHHHHHHHHH	29.86	29472430
294	Phosphorylation	GSAAQSLSKACTIAI HHHHHHHHHHHHHHH	24.37	29472430
295	Succinylation	SAAQSLSKACTIAIR HHHHHHHHHHHHHHH	53.42	24315375
297	S-palmitoylation	AQSLSKACTIAIRYS HHHHHHHHHHHHHHH	3.04	26165157
310	Phosphorylation	YSAVRRQSEIKRSEP HHHHHCHHHHCCCCC	39.20	4317759
313	Acetylation	VRRQSEIKRSEPEPQ HHCHHHHCCCCCCCC	45.91	23864654
315	Phosphorylation	RQSEIKRSEPEPQIL CHHHHCCCCCCCCCC	53.12	59149993
330	Acetylation	DFQTQQYKLFPLLAT CCCCHHHHHHHHHHH	39.04	23864654
349	Acetylation	HFLGRYIKETYMRIN HHHHHHHHHHHHHHH	34.76	23864654
349	Succinylation	HFLGRYIKETYMRIN HHHHHHHHHHHHHHH	34.76	-
349	Succinylation	HFLGRYIKETYMRIN HHHHHHHHHHHHHHH	34.76	23806337
349	Ubiquitination	HFLGRYIKETYMRIN HHHHHHHHHHHHHHH	34.76	27667366
358	Phosphorylation	TYMRINESIGQGDLS HHHHHHHCCCCCCHH	27.77	35096103
365	Phosphorylation	SIGQGDLSELPELHA CCCCCCHHHCHHHHH	41.65	59150187
392	S-nitrosocysteine	ANAGIEECRMACGGH CCCCHHHHHHHHCCC	2.03	-
392	S-nitrosylation	ANAGIEECRMACGGH CCCCHHHHHHHHCCC	2.03	21278135
392	S-palmitoylation	ANAGIEECRMACGGH CCCCHHHHHHHHCCC	2.03	28526873
437	Acetylation	QTARFLMKIYDQVQS HHHHHHHHHHHHHHC	40.02	23576753
437	Malonylation	QTARFLMKIYDQVQS HHHHHHHHHHHHHHC	40.02	26320211
437	Succinylation	QTARFLMKIYDQVQS HHHHHHHHHHHHHHC	40.02	-
437	Succinylation	QTARFLMKIYDQVQS HHHHHHHHHHHHHHC	40.02	23806337
437	Ubiquitination	QTARFLMKIYDQVQS HHHHHHHHHHHHHHC	40.02	-
444	Phosphorylation	KIYDQVQSGKLVGGM HHHHHHHCCCCCCHH	38.75	25195567
444	Ubiquitination	KIYDQVQSGKLVGGM HHHHHHHCCCCCCHH	38.75	27667366
446	Acetylation	YDQVQSGKLVGGMVS HHHHHCCCCCCHHHH	45.29	23576753
446	Succinylation	YDQVQSGKLVGGMVS HHHHHCCCCCCHHHH	45.29	-
446	Succinylation	YDQVQSGKLVGGMVS HHHHHCCCCCCHHHH	45.29	23806337
446	Ubiquitination	YDQVQSGKLVGGMVS HHHHHCCCCCCHHHH	45.29	-
453	Phosphorylation	KLVGGMVSYLNDLPS CCCCHHHHHHHCCCC	18.27	23140645
488	Acetylation	DSLTEAYKLRAARLV HHHHHHHHHHHHHHH	38.25	23954790
488	Succinylation	DSLTEAYKLRAARLV HHHHHHHHHHHHHHH	38.25	24315375
488	Ubiquitination	DSLTEAYKLRAARLV HHHHHHHHHHHHHHH	38.25	-
500	Acetylation	RLVEIAAKNLQAQVS HHHHHHHHHHHHHHC	49.52	23954790
500	Succinylation	RLVEIAAKNLQAQVS HHHHHHHHHHHHHHC	49.52	24315375
500	Ubiquitination	RLVEIAAKNLQAQVS HHHHHHHHHHHHHHC	49.52	-
507	Phosphorylation	KNLQAQVSHRKSKEV HHHHHHHCCCCCCHH	12.90	59151943
511	Phosphorylation	AQVSHRKSKEVAWNL HHHCCCCCCHHHCCC	33.72	108430779
512	Acetylation	QVSHRKSKEVAWNLT HHCCCCCCHHHCCCC	60.28	23576753
512	Succinylation	QVSHRKSKEVAWNLT HHCCCCCCHHHCCCC	60.28	-
512	Succinylation	QVSHRKSKEVAWNLT HHCCCCCCHHHCCCC	60.28	23806337
512	Ubiquitination	QVSHRKSKEVAWNLT HHCCCCCCHHHCCCC	60.28	27667366
527	Phosphorylation	SVDLVRASEAHCHYV HHHHHHHHHCCCEEE	25.42	22807455
531	S-nitrosocysteine	VRASEAHCHYVTVKV HHHHHCCCEEEEEEH	2.97	-
531	S-nitrosylation	VRASEAHCHYVTVKV HHHHHCCCEEEEEEH	2.97	21278135
537	Acetylation	HCHYVTVKVFADKLP CCEEEEEEHHHHCCC	23.44	23864654
537	Succinylation	HCHYVTVKVFADKLP CCEEEEEEHHHHCCC	23.44	24315375
542	Acetylation	TVKVFADKLPKIQDR EEEHHHHCCCHHHHH	64.36	23864654
542	Glutarylation	TVKVFADKLPKIQDR EEEHHHHCCCHHHHH	64.36	24703693
542	Succinylation	TVKVFADKLPKIQDR EEEHHHHCCCHHHHH	64.36	-
542	Succinylation	TVKVFADKLPKIQDR EEEHHHHCCCHHHHH	64.36	23806337
542	Ubiquitination	TVKVFADKLPKIQDR EEEHHHHCCCHHHHH	64.36	-
545	Acetylation	VFADKLPKIQDRAVQ HHHHCCCHHHHHHHH	64.53	23864654
545	Glutarylation	VFADKLPKIQDRAVQ HHHHCCCHHHHHHHH	64.53	24703693
559	S-nitrosocysteine	QAVLRNLCLLYSLYG HHHHHHHHHHHHHHC	2.55	-
559	S-nitrosylation	QAVLRNLCLLYSLYG HHHHHHHHHHHHHHC	2.55	21278135
559	S-palmitoylation	QAVLRNLCLLYSLYG HHHHHHHHHHHHHHC	2.55	26165157
624	Phosphorylation	LGSVLGRYDGNVYEN HHHHHEECCCCHHHH	26.80	25195567
629	Phosphorylation	GRYDGNVYENLFEWA EECCCCHHHHHHHHH	11.78	17242355
637	Acetylation	ENLFEWAKKSPLNKT HHHHHHHHHCCCCCH	55.65	23576753
637	Succinylation	ENLFEWAKKSPLNKT HHHHHHHHHCCCCCH	55.65	-
637	Succinylation	ENLFEWAKKSPLNKT HHHHHHHHHCCCCCH	55.65	23806337
638	Acetylation	NLFEWAKKSPLNKTE HHHHHHHHCCCCCHH	49.94	2374599
638	Succinylation	NLFEWAKKSPLNKTE HHHHHHHHCCCCCHH	49.94	24315375
643	Acetylation	AKKSPLNKTEVHESY HHHCCCCCHHHHHHH	54.46	23864654
643	Malonylation	AKKSPLNKTEVHESY HHHCCCCCHHHHHHH	54.46	26320211
643	Succinylation	AKKSPLNKTEVHESY HHHCCCCCHHHHHHH	54.46	-
643	Succinylation	AKKSPLNKTEVHESY HHHCCCCCHHHHHHH	54.46	23806337
643	Ubiquitination	AKKSPLNKTEVHESY HHHCCCCCHHHHHHH	54.46	-
644	Phosphorylation	KKSPLNKTEVHESYY HHCCCCCHHHHHHHH	42.01	55992781
649	Phosphorylation	NKTEVHESYYKHLKP CCHHHHHHHHHHHHH	20.91	17208939
650	Phosphorylation	KTEVHESYYKHLKPL CHHHHHHHHHHHHHH	17.35	73245799
651	Phosphorylation	TEVHESYYKHLKPLQ HHHHHHHHHHHHHHH	10.95	23140645
652	Acetylation	EVHESYYKHLKPLQS HHHHHHHHHHHHHHH	33.94	23576753
652	Succinylation	EVHESYYKHLKPLQS HHHHHHHHHHHHHHH	33.94	24315375
652	Ubiquitination	EVHESYYKHLKPLQS HHHHHHHHHHHHHHH	33.94	-
655	Acetylation	ESYYKHLKPLQSKL- HHHHHHHHHHHHCC-	43.32	23864654
655	Glutarylation	ESYYKHLKPLQSKL- HHHHHHHHHHHHCC-	43.32	24703693
655	Succinylation	ESYYKHLKPLQSKL- HHHHHHHHHHHHCC-	43.32	-
655	Succinylation	ESYYKHLKPLQSKL- HHHHHHHHHHHHCC-	43.32	23806337
660	Acetylation	HLKPLQSKL------ HHHHHHHCC------	45.30	2374607
660	Succinylation	HLKPLQSKL------ HHHHHHHCC------	45.30	24315375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACOX1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACOX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACOX1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACOX1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-267 AND LYS-643, AND MASSSPECTROMETRY.
PubMed: 16916647

Phosphorylation

"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310 AND SER-649, ANDMASS SPECTROMETRY.
PubMed: 17208939