ACOT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACOT1_HUMAN
• UniProt AC: Q86TX2
• Protein Name: Acyl-coenzyme A thioesterase 1
• Gene Name: ACOT1
• Organism: Homo sapiens (Human).
• Sequence Length: 421
• Subcellular Localization: Cytoplasm .
• Protein Description: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity)..
• Protein Sequence: MAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGRLLCRVRHERYFLPPGVRREPVRAGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAVNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLRYKGETLPPVGVNRNRIKVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPETGHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIPSKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Methylation	EPVRIAVRGLAPEQP CCCEEEEECCCCCCC	25.94	-
37	Phosphorylation	QPVTLRASLRDEKGA CCEEEEEEECCCCCC	19.94	23532336
42	Acetylation	RASLRDEKGALFQAH EEEECCCCCCHHHHH	54.49	2403393
52	Phosphorylation	LFQAHARYRADTLGE HHHHHHHHCCCCCCC	15.78	27251275
56	Phosphorylation	HARYRADTLGELDLE HHHHCCCCCCCCCHH	35.36	30266825
100	Phosphorylation	LVKRDVRTPLAVELE HHHCCCCCCEEEEEE	23.62	72593193
166	Phosphorylation	GIVDMFGTGGGLLEY CCEECCCCCCCHHHH	22.76	22210691
232	Phosphorylation	GVGLLGISKGGELCL CEEEEEECCHHHHHH	24.37	24275569
240	Phosphorylation	KGGELCLSMASFLKG CHHHHHHHHHHHHCC	16.00	22210691
243	Phosphorylation	ELCLSMASFLKGITA HHHHHHHHHHCCCCE	23.59	24719451
257	Phosphorylation	AAVVINGSVANVGGT EEEEECCEEECCCCE	17.36	69214229
264	Phosphorylation	SVANVGGTLRYKGET EEECCCCEEEECCCC	11.35	22210691
267	Phosphorylation	NVGGTLRYKGETLPP CCCCEEEECCCCCCC	26.85	22210691
286	Ubiquitination	RNRIKVTKDGYADIV CCCEEECCCCCCHHH	52.74	21890473
289	Phosphorylation	IKVTKDGYADIVDVL EEECCCCCCHHHHHH	15.96	-
306	Ubiquitination	PLEGPDQKSFIPVER CCCCCCCCCCCCHHH	55.50	-
340	Acetylation	FYANEACKRLQAHGR HHHHHHHHHHHHCCC	64.29	30585289
400	Acetylation	MAQVDAWKQLQTFFH HHHHHHHHHHHHHHH	42.74	30585295
416	O-linked_Glycosylation	HLGGHEGTIPSKV-- HHCCCCCCCCCCC--	27.08	OGP
419	Phosphorylation	GHEGTIPSKV----- CCCCCCCCCC-----	42.05	24719451
420	Ubiquitination	HEGTIPSKV------ CCCCCCCCC------	46.76	-
420	2-Hydroxyisobutyrylation	HEGTIPSKV------ CCCCCCCCC------	46.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACOT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACOT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACOT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CXAR_HUMAN	CXADR	physical	22939629
HIBCH_HUMAN	HIBCH	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.