dbPTM

ACON_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACON_MOUSE
UniProt AC	Q99KI0
Protein Name	Aconitate hydratase, mitochondrial
Gene Name	Aco2
Organism	Mus musculus (Mouse).
Sequence Length	780
Subcellular Localization	Mitochondrion .
Protein Description	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate..
Protein Sequence	MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPSEYIRYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRTDIANLAEEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDADELPRSDFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPSDYNKIHPVDKLTIQGLKDFAPGKPLKCVIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Pyrrolidone_carboxylic_acid	HVASVLCQRAKVAMS HHHHHHHHHHHHHHH	44.18	-
31	Acetylation	SVLCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	23806337
31	Malonylation	SVLCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	26320211
31	Succinylation	SVLCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	-
31	Succinylation	SVLCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	23806337
31	Ubiquitination	SVLCQRAKVAMSHFE HHHHHHHHHHHHCCC	32.49	-
40	Phosphorylation	AMSHFEPSEYIRYDL HHHCCCHHHHHCHHH	35.52	30165576
42	Phosphorylation	SHFEPSEYIRYDLLE HCCCHHHHHCHHHHH	8.60	25195567
50	Acetylation	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	23806337
50	Glutarylation	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	24703693
50	Malonylation	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	26320211
50	Succinylation	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	-
50	Succinylation	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	23806337
50	Ubiquitination	IRYDLLEKNINIVRK HCHHHHHHHHHHHHH	64.20	-
64	Phosphorylation	KRLNRPLTLSEKIVY HHCCCCCCHHCHHHC	30.81	51457869
86	Acetylation	NQEIERGKTYLRLRP HCCHHCCCCEEECCC	39.97	24062335
86	Succinylation	NQEIERGKTYLRLRP HCCHHCCCCEEECCC	39.97	26388266
86	Ubiquitination	NQEIERGKTYLRLRP HCCHHCCCCEEECCC	39.97	27667366
112	Phosphorylation	MAMLQFISSGLPKVA HHHHHHHHCCCCCEE	21.46	357211343
113	Phosphorylation	AMLQFISSGLPKVAV HHHHHHHCCCCCEEC	39.26	357211355
126	S-nitrosocysteine	AVPSTIHCDHLIEAQ ECCCEEECCCCHHHH	2.89	-
126	S-nitrosylation	AVPSTIHCDHLIEAQ ECCCEEECCCCHHHH	2.89	22588120
138	Acetylation	EAQVGGEKDLRRAKD HHHCCCHHHHHHHHH	66.39	23576753
138	Glutarylation	EAQVGGEKDLRRAKD HHHCCCHHHHHHHHH	66.39	24703693
138	Succinylation	EAQVGGEKDLRRAKD HHHCCCHHHHHHHHH	66.39	-
138	Succinylation	EAQVGGEKDLRRAKD HHHCCCHHHHHHHHH	66.39	23806337
144	Acetylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	23806337
144	Succinylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	-
144	Succinylation	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	23806337
144	Ubiquitination	EKDLRRAKDINQEVY HHHHHHHHHHCHHHH	58.28	-
160	Acetylation	FLATAGAKYGVGFWR HHHHCCCCCCCCEEC	41.44	2394507
225	Acetylation	AGIPWELKCPKVIGV CCCCCHHCCCCEEEE	36.66	22733758
228	Acetylation	PWELKCPKVIGVKLT CCHHCCCCEEEEEEE	56.82	24062335
228	Succinylation	PWELKCPKVIGVKLT CCHHCCCCEEEEEEE	56.82	23806337
233	Acetylation	CPKVIGVKLTGSLSG CCCEEEEEEEECCCC	34.81	23576753
233	Succinylation	CPKVIGVKLTGSLSG CCCEEEEEEEECCCC	34.81	-
233	Succinylation	CPKVIGVKLTGSLSG CCCEEEEEEEECCCC	34.81	23806337
235	Phosphorylation	KVIGVKLTGSLSGWT CEEEEEEEECCCCCC	21.00	29472430
237	Phosphorylation	IGVKLTGSLSGWTSP EEEEEEECCCCCCCH	17.71	23737553
239	Phosphorylation	VKLTGSLSGWTSPKD EEEEECCCCCCCHHH	33.70	29472430
242	Phosphorylation	TGSLSGWTSPKDVIL EECCCCCCCHHHHHE	38.38	20469934
243	Phosphorylation	GSLSGWTSPKDVILK ECCCCCCCHHHHHEE	24.36	19060867
245	Acetylation	LSGWTSPKDVILKVA CCCCCCHHHHHEEEE	65.48	24062335
245	Succinylation	LSGWTSPKDVILKVA CCCCCCHHHHHEEEE	65.48	23954790
245	Ubiquitination	LSGWTSPKDVILKVA CCCCCCHHHHHEEEE	65.48	27667366
250	Acetylation	SPKDVILKVAGILTV CHHHHHEEEEEEEEE	20.93	24062335
304	Acetylation	FPYNHRMKKYLSKTG CCCCHHHHHHHHHCC	37.92	24062335
305	Acetylation	PYNHRMKKYLSKTGR CCCHHHHHHHHHCCC	41.92	24062335
308	Phosphorylation	HRMKKYLSKTGRTDI HHHHHHHHHCCCCCH	25.69	22817900
309	Acetylation	RMKKYLSKTGRTDIA HHHHHHHHCCCCCHH	53.02	24062335
309	Succinylation	RMKKYLSKTGRTDIA HHHHHHHHCCCCCHH	53.02	26388266
309	Ubiquitination	RMKKYLSKTGRTDIA HHHHHHHHCCCCCHH	53.02	27667366
370	Acetylation	DVGTVAEKEGWPLDI CCCCHHHHCCCCCEE	52.36	23954790
385	S-nitrosocysteine	RVGLIGSCTNSSYED EEEEEECCCCCCHHH	3.35	-
385	Glutathionylation	RVGLIGSCTNSSYED EEEEEECCCCCCHHH	3.35	24333276
385	S-nitrosylation	RVGLIGSCTNSSYED EEEEEECCCCCCHHH	3.35	24895380
385	S-palmitoylation	RVGLIGSCTNSSYED EEEEEECCCCCCHHH	3.35	28526873
386	Phosphorylation	VGLIGSCTNSSYEDM EEEEECCCCCCHHHH	39.57	26525534
389	Phosphorylation	IGSCTNSSYEDMGRS EECCCCCCHHHHHHH	34.31	26525534
401	Acetylation	GRSAAVAKQALAHGL HHHHHHHHHHHHCCC	29.52	24062335
401	Succinylation	GRSAAVAKQALAHGL HHHHHHHHHHHHCCC	29.52	23806337
401	Ubiquitination	GRSAAVAKQALAHGL HHHHHHHHHHHHCCC	29.52	-
409	Acetylation	QALAHGLKCKSQFTI HHHHCCCCCEEEEEE	44.18	23576753
409	Methylation	QALAHGLKCKSQFTI HHHHCCCCCEEEEEE	44.18	-
410	S-nitrosocysteine	ALAHGLKCKSQFTIT HHHCCCCCEEEEEEC	6.53	-
410	S-nitrosylation	ALAHGLKCKSQFTIT HHHCCCCCEEEEEEC	6.53	21278135
410	S-palmitoylation	ALAHGLKCKSQFTIT HHHCCCCCEEEEEEC	6.53	26165157
411	Acetylation	LAHGLKCKSQFTITP HHCCCCCEEEEEECC	45.78	23864654
411	Succinylation	LAHGLKCKSQFTITP HHCCCCCEEEEEECC	45.78	-
411	Succinylation	LAHGLKCKSQFTITP HHCCCCCEEEEEECC	45.78	23806337
415	Phosphorylation	LKCKSQFTITPGSEQ CCCEEEEEECCCCHH	19.12	22871156
417	Phosphorylation	CKSQFTITPGSEQIR CEEEEEECCCCHHHE	20.66	22871156
448	Glutathionylation	GIVLANACGPCIGQW CEEEECCCCCCCCCC	6.66	24333276
448	S-nitrosylation	GIVLANACGPCIGQW CEEEECCCCCCCCCC	6.66	22588120
448	S-palmitoylation	GIVLANACGPCIGQW CEEEECCCCCCCCCC	6.66	28680068
451	Glutathionylation	LANACGPCIGQWDRK EECCCCCCCCCCCHH	3.11	24333276
451	S-nitrosylation	LANACGPCIGQWDRK EECCCCCCCCCCCHH	3.11	22588120
451	S-palmitoylation	LANACGPCIGQWDRK EECCCCCCCCCCCHH	3.11	28680068
458	Acetylation	CIGQWDRKDIKKGEK CCCCCCHHHHCCCCC	62.42	2394563
461	Acetylation	QWDRKDIKKGEKNTI CCCHHHHCCCCCCEE	65.93	6269781
462	Acetylation	WDRKDIKKGEKNTIV CCHHHHCCCCCCEEE	73.05	24062335
465	Acetylation	KDIKKGEKNTIVTSY HHHCCCCCCEEEEEE	68.97	23864654
465	Succinylation	KDIKKGEKNTIVTSY HHHCCCCCCEEEEEE	68.97	24315375
477	Phosphorylation	TSYNRNFTGRNDANP EEEECCCCCCCCCCC	38.49	7687181
497	Phosphorylation	VTSPEIVTALAIAGT ECCHHHHHHHHHHCC	22.93	55446147
511	Phosphorylation	TLKFNPETDFLTGKD CCCCCCCCCCCCCCC	33.05	25159016
515	Phosphorylation	NPETDFLTGKDGKKF CCCCCCCCCCCCCEE	42.02	25159016
517	Acetylation	ETDFLTGKDGKKFKL CCCCCCCCCCCEEEE	59.06	23576753
517	Glutarylation	ETDFLTGKDGKKFKL CCCCCCCCCCCEEEE	59.06	24703693
517	Succinylation	ETDFLTGKDGKKFKL CCCCCCCCCCCEEEE	59.06	-
517	Succinylation	ETDFLTGKDGKKFKL CCCCCCCCCCCEEEE	59.06	23806337
517	Ubiquitination	ETDFLTGKDGKKFKL CCCCCCCCCCCEEEE	59.06	27667366
520	Acetylation	FLTGKDGKKFKLEAP CCCCCCCCEEEEECC	66.23	24062335
520	Succinylation	FLTGKDGKKFKLEAP CCCCCCCCEEEEECC	66.23	26388266
521	Acetylation	LTGKDGKKFKLEAPD CCCCCCCEEEEECCC	53.94	24062335
521	Succinylation	LTGKDGKKFKLEAPD CCCCCCCEEEEECCC	53.94	26388266
523	Acetylation	GKDGKKFKLEAPDAD CCCCCEEEEECCCCC	55.06	23576753
523	Glutarylation	GKDGKKFKLEAPDAD CCCCCEEEEECCCCC	55.06	24703693
523	Succinylation	GKDGKKFKLEAPDAD CCCCCEEEEECCCCC	55.06	-
523	Succinylation	GKDGKKFKLEAPDAD CCCCCEEEEECCCCC	55.06	23806337
535	Phosphorylation	DADELPRSDFDPGQD CCCCCCHHHCCCCCC	40.46	57405001
543	Phosphorylation	DFDPGQDTYQHPPKD HCCCCCCCCCCCCCC	19.73	27742792
549	Acetylation	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	24062335
549	Glutarylation	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	24703693
549	Malonylation	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	26320211
549	Succinylation	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	-
549	Succinylation	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	23806337
549	Ubiquitination	DTYQHPPKDSSGQRV CCCCCCCCCCCCCCC	74.76	-
551	Phosphorylation	YQHPPKDSSGQRVDV CCCCCCCCCCCCCCC	42.36	27742792
552	Phosphorylation	QHPPKDSSGQRVDVS CCCCCCCCCCCCCCC	49.42	27742792
559	Phosphorylation	SGQRVDVSPTSQRLQ CCCCCCCCCCHHHHH	20.28	26824392
561	Phosphorylation	QRVDVSPTSQRLQLL CCCCCCCCHHHHHHC	29.95	27742792
562	Phosphorylation	RVDVSPTSQRLQLLE CCCCCCCHHHHHHCC	19.38	25159016
573	Acetylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	23864654
573	Succinylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	-
573	Succinylation	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	23806337
573	Ubiquitination	QLLEPFDKWDGKDLE HHCCCCCCCCCCCHH	47.79	-
577	Acetylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	24062335
577	Succinylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	-
577	Succinylation	PFDKWDGKDLEDLQI CCCCCCCCCHHHHEE	57.58	23806337
591	Acetylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	23806337
591	Glutarylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	24703693
591	Succinylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	-
591	Succinylation	ILIKVKGKCTTDHIS EEEEECCEECCCCHH	23.77	23806337
592	S-nitrosocysteine	LIKVKGKCTTDHISA EEEECCEECCCCHHC	7.26	-
592	Glutathionylation	LIKVKGKCTTDHISA EEEECCEECCCCHHC	7.26	24333276
592	S-nitrosylation	LIKVKGKCTTDHISA EEEECCEECCCCHHC	7.26	24895380
593	Phosphorylation	IKVKGKCTTDHISAA EEECCEECCCCHHCC	38.45	37278077
594	Phosphorylation	KVKGKCTTDHISAAG EECCEECCCCHHCCC	34.74	20495213
605	Acetylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	23576753
605	Succinylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	-
605	Succinylation	SAAGPWLKFRGHLDN HCCCCCCEECCCHHH	29.19	23806337
628	Acetylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	23864654
628	Succinylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	-
628	Succinylation	AINIENGKANSVRNA EEEEECCCCCHHHHH	56.85	23806337
646	Phosphorylation	EFGPVPDTARYYKKH HCCCCCCHHHHHHHH	13.63	-
648	Dimethylation	GPVPDTARYYKKHGI CCCCCHHHHHHHHCC	37.09	-
651	Acetylation	PDTARYYKKHGIRWV CCHHHHHHHHCCEEE	29.38	6269773
652	Acetylation	DTARYYKKHGIRWVV CHHHHHHHHCCEEEE	30.83	6269775
665	Phosphorylation	VVIGDENYGEGSSRE EEECCCCCCCCCCCC	17.95	22817900
669	Phosphorylation	DENYGEGSSREHAAL CCCCCCCCCCCCCCC	23.17	26525534
670	Phosphorylation	ENYGEGSSREHAALE CCCCCCCCCCCCCCC	53.17	26525534
689	Acetylation	GGRAIITKSFARIHE CCEEEEEHHHHHHHH	32.92	23864654
689	Succinylation	GGRAIITKSFARIHE CCEEEEEHHHHHHHH	32.92	-
689	Succinylation	GGRAIITKSFARIHE CCEEEEEHHHHHHHH	32.92	23806337
689	Ubiquitination	GGRAIITKSFARIHE CCEEEEEHHHHHHHH	32.92	27667366
700	Acetylation	RIHETNLKKQGLLPL HHHHHCCHHCCCCCC	45.16	23864654
700	Succinylation	RIHETNLKKQGLLPL HHHHHCCHHCCCCCC	45.16	23954790
701	Acetylation	IHETNLKKQGLLPLT HHHHCCHHCCCCCCE	53.41	22826441
701	Ubiquitination	IHETNLKKQGLLPLT HHHHCCHHCCCCCCE	53.41	17451654
713	Phosphorylation	PLTFADPSDYNKIHP CCEECCHHHCCCCCC	53.96	22817900
717	Acetylation	ADPSDYNKIHPVDKL CCHHHCCCCCCCCEE	35.84	23864654
723	Acetylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	23576753
723	Succinylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	-
723	Succinylation	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	23806337
723	Ubiquitination	NKIHPVDKLTIQGLK CCCCCCCEEEECCCC	48.00	-
730	Acetylation	KLTIQGLKDFAPGKP EEEECCCCCCCCCCC	58.59	23576753
730	Succinylation	KLTIQGLKDFAPGKP EEEECCCCCCCCCCC	58.59	-
730	Succinylation	KLTIQGLKDFAPGKP EEEECCCCCCCCCCC	58.59	23806337
736	Acetylation	LKDFAPGKPLKCVIK CCCCCCCCCEEEEEE	46.23	23576753
736	Succinylation	LKDFAPGKPLKCVIK CCCCCCCCCEEEEEE	46.23	23806337
736	Ubiquitination	LKDFAPGKPLKCVIK CCCCCCCCCEEEEEE	46.23	-
739	Acetylation	FAPGKPLKCVIKHPN CCCCCCEEEEEECCC	34.68	23576753
739	Succinylation	FAPGKPLKCVIKHPN CCCCCCEEEEEECCC	34.68	24315375
740	S-nitrosocysteine	APGKPLKCVIKHPNG CCCCCEEEEEECCCC	5.15	-
740	S-nitrosylation	APGKPLKCVIKHPNG CCCCCEEEEEECCCC	5.15	21278135
743	Acetylation	KPLKCVIKHPNGTQE CCEEEEEECCCCCEE	32.39	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACON_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACON_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACON_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ACON_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACON_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-50, AND MASS SPECTROMETRY.	16916647 [Abstract]
Ubiquitylation
Reference	PubMed
"A proteomics approach to identify the ubiquitinated proteins in mouseheart."; Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K.,Choi H.W., Park Z.-Y., Yoo Y.J.; Biochem. Biophys. Res. Commun. 357:731-736(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-144, AND MASSSPECTROMETRY.	17451654 [Abstract]