ACOC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACOC_RAT
• UniProt AC: Q63270
• Protein Name: Cytoplasmic aconitate hydratase
• Gene Name: Aco1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 889
• Subcellular Localization: Cytoplasm.
• Protein Description: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity).; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate..
• Protein Sequence: MKNPFAHLAEPLDPAQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAVRNCDEFLVKKNDIENILNWSIMQHKSIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVCPADLVIDHSIQVHFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFCNMRIIPPGSGIIHQVNLEYLARVVFDQDGCYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDDVSIAYLVQTGREEDKVKHIKRYLQAVGMFRDFSDSSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSEIEKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYNDSEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEAGLNVKPYVKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTVRIDFEKEPLGVNAQGQQVFLKDIWPTRDEIQEVERKYVIPGMFKEVYQKIETVNKSWNALAAPSEKLYAWNPKSTYIKSPPFFESLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPRDFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETLDVFDAAERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIKAVLAESYERTHCSNLVGMGVIPLEYLPGETADSLGLTGRERYTIHIPEHLKPRMKVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Acetylation	LDPAQPGKKFFNLNK CCCCCCCCCCCCCCC	53.76	22902405
20	Acetylation	DPAQPGKKFFNLNKL CCCCCCCCCCCCCCC	62.19	22902405
26	Acetylation	KKFFNLNKLEDSRYG CCCCCCCCCCCCCCC	57.32	22902405
30	Phosphorylation	NLNKLEDSRYGRLPF CCCCCCCCCCCCCCH	20.30	29779826
32	Phosphorylation	NKLEDSRYGRLPFSI CCCCCCCCCCCCHHH	15.56	22673903
79	Acetylation	KSIEVPFKPARVILQ CCCCCCCCCCEEEEE	31.53	22902405
138	Phosphorylation	HFNRRADSLQKNQDL EEECCCHHHHHCCCC	31.54	8262977
141	Acetylation	RRADSLQKNQDLEFE CCCHHHHHCCCCHHH	62.97	22902405
184	Phosphorylation	IHQVNLEYLARVVFD EEECCHHHHEEEEEC	14.61	-
266	Acetylation	DIVLTITKHLRQVGV HHHHHHHHHHHHHCC	36.47	22902405
396	Acetylation	FESCLGAKQGFKGFQ HHHHHCCCCCCCCEE	49.51	22902405
464	Acetylation	VEAGLNVKPYVKTSL HHCCCCCCCEEEEEE	29.56	22902405
472	Phosphorylation	PYVKTSLSPGSGVVT CEEEEEECCCCCEEE	27.29	30181290
475	Phosphorylation	KTSLSPGSGVVTYYL EEEECCCCCEEEEEE	31.62	30181290
479	Phosphorylation	SPGSGVVTYYLRESG CCCCCEEEEEECCCC	12.21	30181290
480	Phosphorylation	PGSGVVTYYLRESGV CCCCEEEEEECCCCC	6.73	30181290
481	Phosphorylation	GSGVVTYYLRESGVM CCCEEEEEECCCCCH	7.01	30181290
572	Succinylation	TVRIDFEKEPLGVNA EEEEEECCCCCCCCC	65.70	26843850
602	Succinylation	EIQEVERKYVIPGMF HHHHHHHHHCCCHHH	30.29	26843850
610	Acetylation	YVIPGMFKEVYQKIE HCCCHHHHHHHHHHH	37.06	22902405
615	Acetylation	MFKEVYQKIETVNKS HHHHHHHHHHHHHHH	25.48	22902405
621	Ubiquitination	QKIETVNKSWNALAA HHHHHHHHHHHHCCC	53.14	-
621	Acetylation	QKIETVNKSWNALAA HHHHHHHHHHHHCCC	53.14	22902405
630	Phosphorylation	WNALAAPSEKLYAWN HHHCCCCCCCEECCC	42.51	23984901
632	Acetylation	ALAAPSEKLYAWNPK HCCCCCCCEECCCCC	51.65	22902405
639	Acetylation	KLYAWNPKSTYIKSP CEECCCCCCCCCCCC	52.82	22902405
708	Phosphorylation	LTPRDFNSYGSRRGN CCHHHCCCCCCCCCC	30.75	30181290
711	Phosphorylation	RDFNSYGSRRGNDAI HHCCCCCCCCCCCCC	15.57	8262977
736	Acetylation	LLNKFLNKQAPQTVH HHHHHHCCCCCCEEE	50.40	22902405
776	Phosphorylation	LAGKEYGSGSSRDWA ECCCCCCCCCCCHHH	34.30	23984901
778	Phosphorylation	GKEYGSGSSRDWAAK CCCCCCCCCCHHHHC	24.73	23984901
779	Phosphorylation	KEYGSGSSRDWAAKG CCCCCCCCCHHHHCC	37.47	23984901
848	Acetylation	EHLKPRMKVQIKLDT CCCCCCCEEEEEECC	32.06	72627359
852	Acetylation	PRMKVQIKLDTGKTF CCCEEEEEECCCCEE	24.18	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
138	S	Phosphorylation	Kinase	PRKCA	P04409	GPS
138	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
138	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
711	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
711	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACOC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACOC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ACOC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.