| UniProt ID | ACNT1_MOUSE | |
|---|---|---|
| UniProt AC | A2AKK5 | |
| Protein Name | Acyl-coenzyme A amino acid N-acyltransferase 1 {ECO:0000303|PubMed:17116739} | |
| Gene Name | Acnat1 {ECO:0000312|EMBL:ABE98441.1} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 416 | |
| Subcellular Localization | Peroxisome . | |
| Protein Description | Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine.. | |
| Protein Sequence | MMIKLIATPSNALVDEPVSIRATGLPPSQIVTIKATVKDENDNVFQSQAFYKTNEAGEVDLEKTPALGGDYVGVHPMGLFFSLKPKKAFHRLMKKDVMNSPFCICLDLYDSVNWLETVRIPSKASQRVQRWFVGPGVKREQIQEGRVRGALFLPPGKGPFPGIIDLFGVIGGLVEFRASLLASHGFAVLALAYFAYKDLPEKLQEVDLEYFEEAANFLLSHPKIQQPGIGVISTSKGAEIGLAMACYLKQVIATVCINGATTTTAVPLRYQDLVVTPIQQALERMEVHVSGAVCFRHTTQYLQNKNILPVEKAQGKILFIVGENDELLDSKLHAQRAMDRLRRHGRSSGRMLAYPGAGHLIEPPYSPLCFASWQPVLGRPMCFGGDLMAHAAAQEHSWREIQKFFRKHLLQSGSKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | IKLIATPSNALVDEP EEEEECCCCCCCCCC | 30.31 | 23140645 | |
| 38 | Acetylation | VTIKATVKDENDNVF EEEEEEECCCCCCEE | 55.78 | - | |
| 38 | Ubiquitination | VTIKATVKDENDNVF EEEEEEECCCCCCEE | 55.78 | - | |
| 125 | Phosphorylation | VRIPSKASQRVQRWF CCCCCHHHHHHHHHH | 23.43 | - | |
| 138 | Acetylation | WFVGPGVKREQIQEG HHCCCCCCHHHHHCC | 57.01 | - | |
| 138 | Ubiquitination | WFVGPGVKREQIQEG HHCCCCCCHHHHHCC | 57.01 | - | |
| 233 | Phosphorylation | QPGIGVISTSKGAEI CCCEEEEECCCCHHH | 24.99 | 29472430 | |
| 234 | Phosphorylation | PGIGVISTSKGAEIG CCEEEEECCCCHHHH | 24.27 | 29472430 | |
| 235 | Phosphorylation | GIGVISTSKGAEIGL CEEEEECCCCHHHHH | 23.46 | 29472430 | |
| 305 | Succinylation | TTQYLQNKNILPVEK HHHHHHCCCCCCCCC | 32.19 | 24315375 | |
| 312 | Ubiquitination | KNILPVEKAQGKILF CCCCCCCCCCCCEEE | 46.36 | 22790023 | |
| 331 | Acetylation | NDELLDSKLHAQRAM CHHHHHHHHHHHHHH | 43.91 | 23954790 | |
| 331 | Ubiquitination | NDELLDSKLHAQRAM CHHHHHHHHHHHHHH | 43.91 | 22790023 | |
| 403 | Acetylation | HSWREIQKFFRKHLL CCHHHHHHHHHHHHH | 52.73 | - | |
| 407 | Acetylation | EIQKFFRKHLLQSGS HHHHHHHHHHHHHCC | 33.19 | - | |
| 414 | Phosphorylation | KHLLQSGSKL----- HHHHHHCCCC----- | 35.71 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACNT1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACNT1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACNT1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ACNT1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-407, AND MASS SPECTROMETRY. | |
