ACM1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACM1_RAT
• UniProt AC: P08482
• Protein Name: Muscarinic acetylcholine receptor M1
• Gene Name: Chrm1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 460
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
• Protein Description: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover..
• Protein Sequence: MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-linked_Glycosylation	------MNTSVPPAV ------CCCCCCCCC	40.85	-
12	N-linked_Glycosylation	VPPAVSPNITVLAPG CCCCCCCCEEEECCC	34.75	-
228	Phosphorylation	ELAALQGSETPGKGG HHHHHCCCCCCCCCC	25.90	25403869
230	Phosphorylation	AALQGSETPGKGGGS HHHCCCCCCCCCCCC	38.75	25403869
233	Ubiquitination	QGSETPGKGGGSSSS CCCCCCCCCCCCCCC	56.43	-
254	Phosphorylation	GAEGSPESPPGRCCR CCCCCCCCCCCCCCC	39.52	25403869
316	Ubiquitination	SEAQAPTKQPPKSSP CCCCCCCCCCCCCCC	60.80	-
322	Phosphorylation	TKQPPKSSPNTVKRP CCCCCCCCCCCCCCC	28.44	25403869
334	Methylation	KRPTKKGRDRGGKGQ CCCCCCCCCCCCCCC	39.06	26494197
428	Phosphorylation	CNKAFRDTFRLLLLC HHHHHHHHHHHHHHH	13.34	-
451	Phosphorylation	KIPKRPGSVHRTPSR CCCCCCCCCCCCCCC	19.89	25403869
455	Phosphorylation	RPGSVHRTPSRQC-- CCCCCCCCCCCCC--	15.67	25403869
457	Phosphorylation	GSVHRTPSRQC---- CCCCCCCCCCC----	34.08	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACM1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACM1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACM1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ACM1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.