dbPTM

ACL2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACL2_SCHPO
UniProt AC	O13907
Protein Name	Probable ATP-citrate synthase subunit 2
Gene Name	SPAC22A12.16
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	492
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA. Has a central role in de novo lipid synthesis (By similarity)..
Protein Sequence	MSAKSIREYDGKAVLAYWLNRSPSISKEEYKTVSATPAVQLAQIQFPLPTLVIPAESTTYREVVEDVFAKVEQEHPWVKETKLVAKPDQLIKRRGKSGLLKLNATWDEAKEWIRERAGKNQKVQHAVGYLTTFLVEPFVPHPPNTEYYININSVREGDWILFCNEGGVDVGDVDAKARKLLVPVRLSEFPSRATIASTLLSDIPVEQHESLVDFIIRLYSVYVDCQFTYLEINPLVVIPTAKGADVFYLDLAAKLDQTAEFECGAKWAVARAPESLGIKTSGEESGAINADHGPPMVFPAPFGRELSKEEAYVQGLDAKTGASLKLTILNAEGRVWNLVAGGGASVVYADAVAVNGAADELANYGEYSGAPTDGQTYEYAKTVLDLMTRGEPRADGKVLFIGGGIANFTSPAVTFRAIARALGDYKDKLHAHKVSIWVRRAGPNYQEGLRVIREAGKKFDLPLKVYGPECHISGIVPMGLGKAPVEAEWQMA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSAKSIREYDGK ---CCCCCHHCCCCH	26.96	24763107
24	Phosphorylation	YWLNRSPSISKEEYK HHHHCCCCCCHHHHH	40.52	28889911
285	Phosphorylation	IKTSGEESGAINADH CCCCCCCCCCCCCCC	29.26	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACL2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACL2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACL2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ACL2_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACL2_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND MASSSPECTROMETRY.	18257517 [Abstract]