ACHD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACHD_MOUSE
• UniProt AC: P02716
• Protein Name: Acetylcholine receptor subunit delta
• Gene Name: Chrnd
• Organism: Mus musculus (Mouse).
• Sequence Length: 520
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane..
• Protein Sequence: MAGPVLTLGLLAALVVCALPGSWGLNEEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSNLISLKEVEETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISYACNVLVYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQEEENNRSYPIEWIIIDPEGFTENGEWEIVHRAAKLNVDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSRPAEEDPGPRALIRRSSSLGYICKAEEYFSLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQVQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVVTPVMVVGTAWIFLQGVYNQPPLQPFPGDPFSYSEQDKRFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	N-linked_Glycosylation	WDANDFGNITVLRLP CCCCCCCCEEEEECC	27.10	-
167	N-linked_Glycosylation	YFPFDWQNCSLKFSS ECCCCCCCCEEEEEC	17.06	-
193	N-linked_Glycosylation	LKQEEENNRSYPIEW EEHHHHHCCCCCEEE	37.24	-
393	Phosphorylation	YICKAEEYFSLKSRS CEEEHHHHEECCCHH	7.03	24899341
418	Phosphorylation	HGLARRLTTARRPPA HCHHHHHHHCCCCCC	19.32	-
419	Phosphorylation	GLARRLTTARRPPAS CHHHHHHHCCCCCCC	23.82	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
393	Y	Phosphorylation	Kinase	TYR-KINASES	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACHD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACHD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACHD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.